Омега 3 - Курс поліненасичених жирних кислот на 2 супермісяці

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.1):

👇 Omega-3 fatty acids, polyunsaturated fatty acids (омега 3 поліненасичені жирні кислоти) 🌿:

😊🩺 Загальний вплив на здоров'я, самопочуття та захворюваність організму, наслідки дефіцити в організму, запалення - 128 досліджень [1-128]:
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🧠 Мозок, пам'ять: короткострокова і довгострокова, процеси навчання, поліпшення розумових (когнітивних) функцій, сприйняття і засвоєння інформації - 9 досліджень [128-137]:
- Serum Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning during Middle Adulthood.()
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- Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation.()
- Stonehouse W, Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, Kennedy DDHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trialAm J Clin Nutr.(2013 May)
- Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi LCognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjectsEur J Clin Invest.(2005 Nov)
- Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, Stewart R, Huang SYThe effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled studyProg Neuropsychopharmacol Biol Psychiatry.(2008 Aug 1)
- Stough C, Downey L, Silber B, Lloyd J, Kure C, Wesnes K, Camfield DThe effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging populationNeurobiol Aging.(2012 Apr)
- van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, Beekman AT, de Groot CPEffect of fish oil on cognitive performance in older subjects: a randomized, controlled trialNeurology.(2008 Aug 5)
- Antypa N, Van der Does AJ, Smelt AH, Rogers RDOmega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteersJ Psychopharmacol.(2009 Sep)

🩸🧠 Мозковий кровотік, церебральний кровообіг, головний біль, мігрень, мозковий інсульт, гіпоксія мозку, тиск, мозковий інфаркт - 17 досліджень [137-154]:
- Ximenes da Silva A, Lavialle F, Gendrot G, Guesnet P, Alessandri JM, Lavialle MGlucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acidsJ Neurochem.(2002 Jun)
- Pifferi F, Roux F, Langelier B, Alessandri JM, Vancassel S, Jouin M, Lavialle M, Guesnet P(n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in ratsJ Nutr.(2005 Sep)
- Pifferi F, Jouin M, Alessandri JM, Haedke U, Roux F, Perrière N, Denis I, Lavialle M, Guesnet Pn-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrierProstaglandins Leukot Essent Fatty Acids.(2007 Nov-Dec)
- Pifferi F, Jouin M, Alessandri JM, Roux F, Perrière N, Langelier B, Lavialle M, Cunnane S, Guesnet Pn-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cellsNeurochem Int.(2010 Apr)
- Tsukada H, Kakiuchi T, Fukumoto D, Nishiyama S, Koga KDocosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeysBrain Res.(2000 Apr 17)
- Nugent S, Croteau E, Pifferi F, Fortier M, Tremblay S, Turcotte E, Cunnane SCBrain and systemic glucose metabolism in the healthy elderly following fish oil supplementationProstaglandins Leukot Essent Fatty Acids.(2011 Nov)
- Katayama Y, Katsumata T, Muramatsu H, Usuda K, Obo R, Terashi AEffect of long-term administration of ethyl eicosapentate (EPA-E) on local cerebral blood flow and glucose utilization in stroke-prone spontaneously hypertensive rats (SHRSP)Brain Res.(1997 Jul 4)
- Steinbrink J, Villringer A, Kempf F, Haux D, Boden S, Obrig HIlluminating the BOLD signal: combined fMRI-fNIRS studiesMagn Reson Imaging.(2006 May)
- Jackson PA, Reay JL, Scholey AB, Kennedy DODHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot studyBr J Nutr.(2012 Apr)
- Jackson PA, Reay JL, Scholey AB, Kennedy DODocosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adultsBiol Psychol.(2012 Jan)
- Bouzan C, Cohen JT, Connor WE, Kris-Etherton PM, Gray GM, König A, Lawrence RS, Savitz DA, Teutsch SMA quantitative analysis of fish consumption and stroke riskAm J Prev Med.(2005 Nov)
- He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, Goldbourt U, Greenland PFish consumption and incidence of stroke: a meta-analysis of cohort studiesStroke.(2004 Jul)
- Mozaffarian D, Rimm EBFish intake, contaminants, and human health: evaluating the risks and the benefitsJAMA.(2006 Oct 18)
- Mozaffarian D, Longstreth WT Jr, Lemaitre RN, Manolio TA, Kuller LH, Burke GL, Siscovick DSFish consumption and stroke risk in elderly individuals: the cardiovascular health studyArch Intern Med.(2005 Jan 24)
- Yamagishi K, Iso H, Date C, Fukui M, Wakai K, Kikuchi S, Inaba Y, Tanabe N, Tamakoshi A; Japan Collaborative Cohort Study for Evaluation of Cancer Risk Study GroupFish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) StudyJ Am Coll Cardiol.(2008 Sep 16)
- Youdim KA, Martin A, Joseph JAEssential fatty acids and the brain: possible health implicationsInt J Dev Neurosci.(2000 Jul-Aug)
- Salem N Jr, Litman B, Kim HY, Gawrisch KMechanisms of action of docosahexaenoic acid in the nervous systemLipids.(2001 Sep)

🤔 Зниження розумових (когнітивних) функцій, порушення пам'яті, деменція, мозкове старіння, порушення мислення, мови, концентрації, уваги, інтелекту, психомоторний спад, Альцгеймер - 16 досліджень - 27 досліджень [154-181]:
- N-3 Fatty Acid Rich Triglyceride Emulsions Are Neuroprotective after Cerebral Hypoxic-Ischemic Injury in Neonatal Mice.()
- Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle DJ, Wilson PW, Wolf PAPlasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart StudyArch Neurol.(2006 Nov)
- Huang TL, Zandi PP, Tucker KL, Fitzpatrick AL, Kuller LH, Fried LP, Burke GL, Carlson MCBenefits of fatty fish on dementia risk are stronger for those without APOE epsilon4Neurology.(2005 Nov 8)
- Kalmijn S, van Boxtel MP, Ocké M, Verschuren WM, Kromhout D, Launer LJDietary intake of fatty acids and fish in relation to cognitive performance at middle ageNeurology.(2004 Jan 27)
- Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RSFish consumption and cognitive decline with age in a large community studyArch Neurol.(2005 Dec)
- Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau PPlasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobeNeurology.(2012 Aug 14)
- Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging.()
- Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PSDocosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trialJAMA.(2010 Nov 3)
- James MJ, Gibson RA, Cleland LGDietary polyunsaturated fatty acids and inflammatory mediator productionAm J Clin Nutr.(2000 Jan)
- Xiang Z, Ho L, Yemul S, Zhao Z, Qing W, Pompl P, Kelley K, Dang A, Qing W, Teplow D, Pasinetti GMCyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathologyGene Expr.(2002)
- Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity.()
- Strokin M, Sergeeva M, Reiser GProstaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2J Neurochem.(2007 Sep)
- de Wilde MC, van der Beek EM, Kiliaan AJ, Leenders I, Kuipers AA, Kamphuis PJ, Broersen LMDocosahexaenoic acid reduces amyloid-β(1-42) secretion in human AβPP-transfected CHO-cells by mechanisms other than inflammation related to PGE₂J Alzheimers Dis.(2010)
- Hashimoto M, Tanabe Y, Fujii Y, Kikuta T, Shibata H, Shido OChronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused ratsJ Nutr.(2005 Mar)
- Hashimoto M, Hossain S, Shimada T, Sugioka K, Yamasaki H, Fujii Y, Ishibashi Y, Oka J, Shido ODocosahexaenoic acid provides protection from impairment of learning in amyloid beta-infused ratsJ Neurochem.(2002 Jun)
- Hashimoto M, Hossain S, Shimada T, Shido ODocosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidityClin Exp Pharmacol Physiol.(2006 Oct)
- Shim KS, Lubec GDrebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndromeNeurosci Lett.(2002 May 24)
- Selkoe DJAlzheimer's disease is a synaptic failureScience.(2002 Oct 25)
- Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GMDocosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse modelNeuron.(2004 Sep 2)
- Wurtman RJSynapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituentsMetabolism.(2008 Oct)
- Sakamoto T, Cansev M, Wurtman RJOral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampusBrain Res.(2007 Nov 28)
- Freund-Levi Y, Eriksdotter-Jönhagen M, Cederholm T, Basun H, Faxén-Irving G, Garlind A, Vedin I, Vessby B, Wahlund LO, Palmblad JOmega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trialArch Neurol.(2006 Oct)
- Freund-Levi Y, Basun H, Cederholm T, Faxén-Irving G, Garlind A, Grut M, Vedin I, Palmblad J, Wahlund LO, Eriksdotter-Jönhagen MOmega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptomsInt J Geriatr Psychiatry.(2008 Feb)
- Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS InvestigatorsBeneficial effects of docosahexaenoic acid on cognition in age-related cognitive declineAlzheimers Dement.(2010 Nov)
- Dangour AD, Allen E, Elbourne D, Fasey N, Fletcher AE, Hardy P, Holder GE, Knight R, Letley L, Richards M, Uauy REffect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trialAm J Clin Nutr.(2010 Jun)
- Chew EY, Clemons TE, Agrón E, Launer LJ, Grodstein F, Bernstein PS, Age-Related Eye Disease Study 2 (AREDS2) Research GroupEffect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical TrialJAMA.(2015 Aug 25)
- Rozzini L, Riva M, Ghilardi N, Facchinetti P, Forbice E, Semeraro F, Padovani ACognitive dysfunction and age-related macular degenerationAm J Alzheimers Dis Other Demen.(2014 May)

❤️ Серцево-судинне здоров'я: серце, судини, артерії, вени, атеросклероз, варикоз, холестерин, тромбоз, ліпіди, міокард, антикоагулянт, розрідження крові - 44 дослідження [181-225]:
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- Kastelein J. What future for combination therapies. Int J Clin Pract Suppl. (2003 Mar)
- Barter PJ. Hugh sinclair lecture: the regulation and remodelling of HDL by plasma factors. Atheroscler Suppl. (2002 Dec)
- Boberg M, Pollare T, Siegbahn A, Vessby B. Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetes mellitus. Eur J Clin Invest. (1992 Oct)
- Connor WE, Prince MJ, Ullmann D, Riddle M, Hatcher L, Smith FE, Wilson D. The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control. Ann N Y Acad Sci. (1993 Jun 14)
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- de Silva PP, Davis PJ, Cheema SK. Hyperlipidaemic effect of fish oil in Bio F1B hamsters. Br J Nutr. (2004 Mar)
- Ishida T, Ohta M, Nakakuki M, Kami H, Uchiyama R, Kawano H, Notsu T, Imada K, Shimano H. Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: Participation of cholesterol ester transfer protein and LDL receptor. Prostaglandins Leukot Essent Fatty Acids. (2013 Apr)
- Wei MY, Jacobson TA. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep. (2011 Dec)
- Eslick GD, Howe PR, Smith C, Priest R, Bensoussan A. Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol. (2009 Jul 24)
- Stradling C, Chen YF, Russell T, Connock M, Thomas GN, Taheri S. The effects of dietary intervention on HIV dyslipidemia: a systematic review and meta-analysis. PLoS One. (2012)
- Pei J, Zhao Y, Huang L, Zhang X, Wu Y. The effect of n-3 polyunsaturated fatty acids on plasma lipids and lipoproteins in patients with chronic renal failure--a meta-analysis of randomized controlled trials. J Ren Nutr. (2012 Nov)
- Hartweg J, Farmer AJ, Holman RR, Neil A. Potential impact of omega-3 treatment on cardiovascular disease in type 2 diabetes. Curr Opin Lipidol. (2009 Feb)
- Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. (1997 May)
- Theobald HE, Chowienczyk PJ, Whittall R, Humphries SE, Sanders TA. LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. Am J Clin Nutr. (2004 Apr)
- Davidson MH, Stein EA, Bays HE, Maki KC, Doyle RT, Shalwitz RA, Ballantyne CM, Ginsberg HN; COMBination of prescription Omega-3 with Simvastatin (COMBOS) Investigators. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther. (2007 Jul)
- Stark KD, Holub BJ. Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr. (2004 May)
- Kelley DS, Siegel D, Vemuri M, Mackey BE. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr. (2007 Aug)
- Maki KC, Van Elswyk ME, McCarthy D, Hess SP, Veith PE, Bell M, Subbaiah P, Davidson MH. Lipid responses to a dietary docosahexaenoic acid supplement in men and women with below average levels of high-density lipoprotein cholesterol. J Am Coll Nutr. (2005 Jun)
- Geppert J, Kraft V, Demmelmair H, Koletzko B. Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidemic vegetarians: a randomized trial. Br J Nutr. (2006 Apr)
- Conquer JA, Holub BJ. Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. J Nutr. (1996 Dec)
- Agren JJ, Hänninen O, Julkunen A, Fogelholm L, Vidgren H, Schwab U, Pynnönen O, Uusitupa M. Fish diet, fish oil and docosahexaenoic acid-rich oil lower fasting and postprandial plasma lipid levels. Eur J Clin Nutr. (1996 Nov)
- Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD, Beilin LJ. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. (2000 May)
- Ando M, Sanaka T, Nihei H. Eicosapentanoic acid reduces plasma levels of remnant lipoproteins and prevents in vivo peroxidation of LDL in dialysis patients. J Am Soc Nephrol. (1999 Oct)
- Satoh N, Shimatsu A, Kotani K, Sakane N, Yamada K, Suganami T, Kuzuya H, Ogawa Y. Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome. Diabetes Care. (2007 Jan)
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- Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res. (2003 Mar)
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- Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr. (2002 Aug)
- Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr. (2002 Nov)
- Mori TA, Woodman RJ. The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Curr Opin Clin Nutr Metab Care. (2006 Mar)
- Hanwell HE, Kay CD, Lampe JW, Holub BJ, Duncan AM. Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men. J Nutr. (2009 Jun)
- Maki KC, Lawless AL, Kelley KM, Dicklin MR, Schild AL, Rains TM. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. Prostaglandins Leukot Essent Fatty Acids. (2011 Sep-Oct)
- Schirmer SH, Werner CM, Binder SB, Faas ME, Custodis F, Böhm M, Laufs U. Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activation. Atherosclerosis. (2012 Nov)
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 - Impact of n-3 fatty acids on endothelial function: results from human interventions studies.()

🩸🍬 Регулювання глюкози (цукру) в крові, цукровий діабет, предіабет, інсулінорезистентність, профілактика діабету - 26 досліджень [225-251]:
- Montori VM, Farmer A, Wollan PC, Dinneen SFFish oil supplementation in type 2 diabetes: a quantitative systematic reviewDiabetes Care.(2000 Sep)
- Friedberg CE, Janssen MJ, Heine RJ, Grobbee DEFish oil and glycemic control in diabetes. A meta-analysisDiabetes Care.(1998 Apr)
- MacLean CH, Mojica WA, Morton SC, Pencharz J, Hasenfeld Garland R, Tu W, Newberry SJ, Jungvig LK, Grossman J, Khanna P, Rhodes S, Shekelle PEffects of omega-3 fatty acids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosisEvid Rep Technol Assess (Summ).(2004 Mar)
- Hartweg J, Perera R, Montori V, Dinneen S, Neil HA, Farmer AOmega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitusCochrane Database Syst Rev.(2008 Jan 23)
- Maki KC, McKenney JM, Reeves MS, Lubin BC, Dicklin MREffects of adding prescription omega-3 acid ethyl esters to simvastatin (20 mg/day) on lipids and lipoprotein particles in men and women with mixed dyslipidemiaAm J Cardiol.(2008 Aug 15)
- Luo J, Rizkalla SW, Vidal H, Oppert JM, Colas C, Boussairi A, Guerre-Millo M, Chapuis AS, Chevalier A, Durand G, Slama GModerate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled studyDiabetes Care.(1998 May)
- Schectman G, Kaul S, Kissebah AHEffect of fish oil concentrate on lipoprotein composition in NIDDMDiabetes.(1988 Nov)
- Giacco R, Cuomo V, Vessby B, Uusitupa M, Hermansen K, Meyer BJ, Riccardi G, Rivellese AA; KANWU Study GroupFish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acidsNutr Metab Cardiovasc Dis.(2007 Oct)
- Egert S, Fobker M, Andersen G, Somoza V, Erbersdobler HF, Wahrburg UEffects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteersAnn Nutr Metab.(2008)
- Bortolotti M, Tappy L, Schneiter PFish oil supplementation does not alter energy efficiency in healthy malesClin Nutr.(2007 Apr)
- Tsitouras PD, Gucciardo F, Salbe AD, Heward C, Harman SMHigh omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adultsHorm Metab Res.(2008 Mar)
- Fedor D, Kelley DSPrevention of insulin resistance by n-3 polyunsaturated fatty acidsCurr Opin Clin Nutr Metab Care.(2009 Mar)
- Ramel A, Martinéz A, Kiely M, Morais G, Bandarra NM, Thorsdottir IBeneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adultsDiabetologia.(2008 Jul)
- Rivellese AA, Maffettone A, Iovine C, Di Marino L, Annuzzi G, Mancini M, Riccardi GLong-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemiaDiabetes Care.(1996 Nov)
- Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SAAdditive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic womenInt J Obes (Lond).(2006 Oct)
- Browning LM, Krebs JD, Moore CS, Mishra GD, O'Connell MA, Jebb SAThe impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotypeDiabetes Obes Metab.(2007 Jan)
- Treatment for 2 mo with n–3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study.()
- Hendrich S(n-3) Fatty Acids: Clinical Trials in People with Type 2 DiabetesAdv Nutr.(2010 Nov)
- Haugaard SB, Madsbad S, Høy CE, Vaag ADietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivityClin Endocrinol {Oxf}.(2006 Feb)
- Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy LEffect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy menDiabetes.(2005 Jul)
- Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli KFructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndromeAm J Physiol Endocrinol Metab.(2010 Nov)
- Hirabara SM, Curi R, Maechler PSaturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cellsJ Cell Physiol.(2010 Jan)
- Sawada K, Kawabata K, Yamashita T, Kawasaki K, Yamamoto N, Ashida HAmeliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cellsLipids Health Dis.(2012 Mar 12)
- Huang T, Bhulaidok S, Cai Z, Xu T, Xu F, Wahlqvist ML, Li DPlasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndromeMol Nutr Food Res.(2010 Nov)
- Lauretani F, Maggio M, Pizzarelli F, Michelassi S, Ruggiero C, Ceda GP, Bandinelli S, Ferrucci LOmega-3 and renal function in older adultsCurr Pharm Des.(2009)
- Huang T, Wahlqvist ML, Xu T, Xu A, Zhang A, Li DIncreased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in ChinaMol Nutr Food Res.(2010 May)

🧠🛡️ Захист нейронів, нейропротекція, нейромодуляція, неврологія - 5 досліджень [251-256]:
- MOHRHAUER H, HOLMAN RTALTERATION OF THE FATTY ACID COMPOSITION OF BRAIN LIPIDS BY VARYING LEVELS OF DIETARY ESSENTIAL FATTY ACIDSJ Neurochem.(1963 Jul)
- Bourre JM, Dumont OS, Piciotti MJ, Pascal GA, Durand GADietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testesBiochim Biophys Acta.(1992 Mar 4)
- Moriguchi T, Harauma A, Salem N JrPlasticity of mouse brain docosahexaenoic Acid: modulation by diet and ageLipids.(2013 Apr)
- Pawlosky RJ, Salem N JrAlcohol consumption in rhesus monkeys depletes tissues of polyunsaturated fatty acids and alters essential fatty acid metabolismAlcohol Clin Exp Res.(1999 Feb)
- Pawlosky RJ, Bacher J, Salem N JrEthanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid dietAlcohol Clin Exp Res.(2001 Dec)

😖 Біполярний афективний розлад - 7 досліджень [256-263]:
- Chronic Sodium Valproate Selectively Decreases Protein Kinase C α and ε In Vitro.()
- Berridge MJ, Downes CP, Hanley MRLithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glandsBiochem J.(1982 Sep 15)
- Evans SJ, Kamali M, Prossin AR, Harrington GJ, Ellingrod VL, McInnis MG, Burant CFAssociation of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjectsJ Psychiatr Res.(2012 Nov)
- Montgomery P, Richardson AJOmega-3 fatty acids for bipolar disorderCochrane Database Syst Rev.(2008 Apr 16)
- Wurtman RJ, Regan M, Ulus I, Yu LEffect of oral CDP-choline on plasma choline and uridine levels in humansBiochem Pharmacol.(2000 Oct 1)
- Murphy BL, Stoll AL, Harris PQ, Ravichandran C, Babb SM, Carlezon WA Jr, Cohen BMOmega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trialJ Clin Psychopharmacol.(2012 Oct)
- Appleton KM, Sallis HM, Perry R, Ness AR, Churchill ROmega-3 fatty acids for depression in adultsCochrane Database Syst Rev.(2015 Nov 5)

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.2):

😔 Стрес, депресія, неврозність, тривожність, пригніченість, печаль, роздратованість, астенія (вигорання), поганий настрій, апатія (відсутність мотивації), проблеми зі сном, серотонін, дофамін, норадреналін, агресія  - 45 досліджень [263-308]:
- Martins JGEPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trialsJ Am Coll Nutr.(2009 Oct)
- Rees AM, Austin MP, Parker GBOmega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trialAust N Z J Psychiatry.(2008 Mar)
- Freeman MP, Davis M, Sinha P, Wisner KL, Hibbeln JR, Gelenberg AJOmega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled studyJ Affect Disord.(2008 Sep)
- Doornbos B, van Goor SA, Dijck-Brouwer DA, Schaafsma A, Korf J, Muskiet FASupplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sampleProg Neuropsychopharmacol Biol Psychiatry.(2009 Feb 1)
- Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WCEffect of maternal docosahexaenoic acid supplementation on postpartum depression and information processingAm J Obstet Gynecol.(2003 May)
- Su KP, Huang SY, Chiu TH, Huang KC, Huang CL, Chang HC, Pariante CMOmega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trialJ Clin Psychiatry.(2008 Apr)
- Nemets B, Stahl Z, Belmaker RHAddition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorderAm J Psychiatry.(2002 Mar)
- Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJA double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depressionAm J Psychiatry.(2003 May)
- Peet M, Horrobin DFA dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugsArch Gen Psychiatry.(2002 Oct)
- Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin SEthyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trialAm J Clin Nutr.(2009 Feb)
- Grenyer BF, Crowe T, Meyer B, Owen AJ, Grigonis-Deane EM, Caputi P, Howe PRFish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trialProg Neuropsychopharmacol Biol Psychiatry.(2007 Oct 1)
- Su KP, Huang SY, Chiu CC, Shen WWOmega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trialEur Neuropsychopharmacol.(2003 Aug)
- Warren G, McKendrick M, Peet MThe role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFAActa Neurol Scand.(1999 Feb)
- Behan PO, Behan WM, Horrobin DEffect of high doses of essential fatty acids on the postviral fatigue syndromeActa Neurol Scand.(1990 Sep)
- Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RMDouble-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderBiol Psychiatry.(2006 Nov 1)
- Hirashima F, Parow AM, Stoll AL, Demopulos CM, Damico KE, Rohan ML, Eskesen JG, Zuo CS, Cohen BM, Renshaw PFOmega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorderAm J Psychiatry.(2004 Oct)
- Frangou S, Lewis M, McCrone PEfficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled studyBr J Psychiatry.(2006 Jan)
- Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LBOmega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trialArch Gen Psychiatry.(1999 May)
- Fenton WS, Dickerson, Boronow J, Hibbeln JR, Knable MA placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophreniaAm J Psychiatry.(2001 Dec)
- da Silva TM, Munhoz RP, Alvarez C, Naliwaiko K, Kiss A, Andreatini R, Ferraz ACDepression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementationJ Affect Disord.(2008 Dec)
- Hallahan B, Hibbeln JR, Davis JM, Garland MROmega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trialBr J Psychiatry.(2007 Feb)
- Zanarini MC, Frankenburg FRomega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot studyAm J Psychiatry.(2003 Jan)
- van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Olderikkert MG, Beekman AT, de Groot LCEffect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trialAm J Clin Nutr.(2008 Sep)
- Rogers PJ, Appleton KM, Kessler D, Peters TJ, Gunnell D, Hayward RC, Heatherley SV, Christian LM, McNaughton SA, Ness ARNo effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trialBr J Nutr.(2008 Feb)
- Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RARandomised double-blind placebo-controlled trial of fish oil in the treatment of depressionProstaglandins Leukot Essent Fatty Acids.(2005 Mar)
- Fontani G, Corradeschi F, Felici A, Alfatti F, Bugarini R, Fiaschi AI, Cerretani D, Montorfano G, Rizzo AM, Berra BBlood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acidsEur J Clin Invest.(2005 Aug)
- Jazayeri S, Tehrani-Doost M, Keshavarz SA, Hosseini M, Djazayery A, Amini H, Jalali M, Peet MComparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorderAust N Z J Psychiatry.(2008 Mar)
- Laino CH, Fonseca C, Sterin-Speziale N, Slobodianik N, Reinés APotentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapineEur J Pharmacol.(2010 Dec 1)
- Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PFAntidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in ratsBiol Psychiatry.(2005 Feb 15)
- Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser ROmega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trialBrain Behav Immun.(2012 Aug)
- van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Olderikkert MG, Beekman AT, de Groot LCEffect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trialJ Am Geriatr Soc.(2009 Aug)
- Hamazaki T, Itomura M, Sawazaki S, Nagao YAnti-stress effects of DHABiofactors.(2000)
- Hamazaki T, Sawazaki S, Itomura M, Asaoka E, Nagao Y, Nishimura N, Yazawa K, Kuwamori T, Kobayashi MThe effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind studyJ Clin Invest.(1996 Feb 15)
- Hamazaki T, Thienprasert A, Kheovichai K, Samuhaseneetoo S, Nagasawa T, Watanabe SThe effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind studyNutr Neurosci.(2002 Feb)
- Hamazaki T, Sawazaki S, Nagao Y, Kuwamori T, Yazawa K, Mizushima Y, Kobayashi MDocosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind studyLipids.(1998 Jul)
- Hibbeln JR, Salem N JrDietary polyunsaturated fatty acids and depression: when cholesterol does not satisfyAm J Clin Nutr.(1995 Jul)
- Long SJ1, Benton DA double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stressHum Psychopharmacol.(2013 May)
- Itomura M, Hamazaki K, Sawazaki S, Kobayashi M, Terasawa K, Watanabe S, Hamazaki TThe effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trialJ Nutr Biochem.(2005 Mar)
- Raine A1, Portnoy J, Liu J, Mahoomed T, Hibbeln JRReduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trialJ Child Psychol Psychiatry.(2014 Aug 22)
- Eguchi R, Scarmagnani FR, Cunha CA, Souza GI, Pisani LP, Ribeiro EB, Oller do Nascimento CM, Spadari-Bratfisch RC, Oyama LMFish oil consumption prevents glucose intolerance and hypercorticosteronemy in footshock-stressed ratsLipids Health Dis.(2011 May 11)
- Hamazaki T, Sawazaki S, Nagasawa T, Nagao Y, Kanagawa Y, Yazawa KAdministration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stressLipids.(1999)
- Sawazaki S, Hamazaki T, Yazawa K, Kobayashi MThe effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled studyJ Nutr Sci Vitaminol (Tokyo).(1999 Oct)
- Song C, Li X, Leonard BE, Horrobin DFEffects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in ratsJ Lipid Res.(2003 Oct)
- Takeuchi T, Iwanaga M, Harada EPossible regulatory mechanism of DHA-induced anti-stress reaction in ratsBrain Res.(2003 Feb 21)
- Hamazaki K, Itomura M, Huan M, Nishizawa H, Sawazaki S, Tanouchi M, Watanabe S, Hamazaki T, Terasawa K, Yazawa KEffect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trialNutrition.(2005 Jun)

🌿🧹 Детокс, очищення організму, антиоксидант, закислення організму, окислення ліпідів, пошкодження ДНК - 37 досліджень [308-345]:
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-Esterbauer H, Schaur RJ, Zollner HChemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesFree Radic Biol Med.(1991)
-Davis TA, Gao L, Yin H, Morrow JD, Porter NAIn vivo and in vitro lipid peroxidation of arachidonate esters: the effect of fish oil omega-3 lipids on product distributionJ Am Chem Soc.(2006 Nov 22)
-Gonzalez MJ, Gray JI, Schemmel RA, Dugan L Jr, Welsch CWLipid peroxidation products are elevated in fish oil diets even in the presence of added antioxidantsJ Nutr.(1992 Nov)
-Seljeskog E, Hervig T, Mansoor MAA novel HPLC method for the measurement of thiobarbituric acid reactive substances (TBARS). A comparison with a commercially available kitClin Biochem.(2006 Sep)
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-Tholstrup T, Hellgren LI, Petersen M, Basu S, Straarup EM, Schnohr P, Sandström BA solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in menJ Nutr.(2004 May)
-Mori TAEffect of fish and fish oil-derived omega-3 fatty acids on lipid oxidationRedox Rep.(2004)
-Nälsén C, Vessby B, Berglund L, Uusitupa M, Hermansen K, Riccardi G, Rivellese A, Storlien L, Erkkilä A, Ylä-Herttuala S, Tapsell L, Basu SDietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humansJ Nutr.(2006 May)
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-Higdon JV, Liu J, Du SH, Morrow JD, Ames BN, Wander RCSupplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanesAm J Clin Nutr.(2000 Sep)
-Ulven SM, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, Berge K, Vik H, Pedersen JIMetabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteersLipids.(2011 Jan)
-Higdon JV, Du SH, Lee YS, Wu T, Wander RCSupplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleateJ Lipid Res.(2001 Mar)
-Calzada C, Colas R, Guillot N, Guichardant M, Laville M, Véricel E, Lagarde MSubgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy menAtherosclerosis.(2010 Feb)
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-Turner R, McLean CH, Silvers KMAre the health benefits of fish oils limited by products of oxidationNutr Res Rev.(2006 Jun)
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-Kikugawa K, Yasuhara Y, Ando K, Koyama K, Hiramoto K, Suzuki MEffect of supplementation of n-3 polyunsaturated fatty acids on oxidative stress-induced DNA damage of rat hepatocytesBiol Pharm Bull.(2003 Sep)
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-Kim YJ, Yokozawa T, Chung HYEffects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W miceBr J Nutr.(2005 Jun)

🛡️ Імунітет, моноцити, макрофаги, клітини-кілери, нейтрофіли, В-клітини, Т-клітини - 80 досліджень [345-425]:
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- Dangardt F, Osika W, Chen Y, Nilsson U, Gan LM, Gronowitz E, Strandvik B, Friberg POmega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescentsAtherosclerosis.(2010 Oct)
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- Ciubotaru I, Lee YS, Wander RCDietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRTJ Nutr Biochem.(2003 Sep)
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- Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DRDietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophilsJ Clin Invest.(1993 Feb)
- Hughes DA, Pinder ACN-3 polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes and inhibit antigen-presentation in vitroClin Exp Immunol.(1997 Dec)
-Miles EA, Wallace FA, Calder PCDietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophagesAtherosclerosis.(2000 Sep)
-Sanderson P, Calder PCDietary fish oil diminishes lymphocyte adhesion to macrophage and endothelial cell monolayersImmunology.(1998 May)
-Collie-Duguid ES, Wahle KWInhibitory effect of fish oil N-3 polyunsaturated fatty acids on the expression of endothelial cell adhesion moleculesBiochem Biophys Res Commun.(1996 Mar 27)
-De Caterina R, Cybulsky MI, Clinton SK, Gimbrone MA Jr, Libby PThe omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cellsArterioscler Thromb.(1994 Nov)
-Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M, Yamamoto Y, Kamei Y, Horie M, Watada H, Ogawa YIn vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acidArterioscler Thromb Vasc Biol.(2008 Dec)
-Hughes DA, Pinder AC, Piper Z, Johnson IT, Lund EKFish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytesAm J Clin Nutr.(1996 Feb)
-Luu NT, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Tull SP, Dastur N, Rainger GE, Nash GBComparison of the pro-inflammatory potential of monocytes from healthy adults and those with peripheral arterial disease using an in vitro culture modelAtherosclerosis.(2007 Aug)
-Miles EA, Thies F, Wallace FA, Powell JR, Hurst TL, Newsholme EA, Calder PCInfluence of age and dietary fish oil on plasma soluble adhesion molecule concentrationsClin Sci (Lond).(2001 Jan)
-Nielsen MS, Gammelmark A, Madsen T, Obel T, Aardestrup I, Schmidt EBThe effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: a randomized controlled trialProstaglandins Leukot Essent Fatty Acids.(2012 Jul)
-Stanke-Labesque F, Molière P, Bessard J, Laville M, Véricel E, Lagarde MEffect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteersBr J Nutr.(2008 Oct)
-Lee TH, Hoover RL, Williams JD, Sperling RI, Ravalese J 3rd, Spur BW, Robinson DR, Corey EJ, Lewis RA, Austen KFEffect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil functionN Engl J Med.(1985 May 9)
-Elbim C, Lizard GFlow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situationsCytometry A.(2009 Jun)
-Bonatto SJ, Oliveira HH, Nunes EA, Pequito D, Iagher F, Coelho I, Naliwaiko K, Kryczyk M, Brito GA, Repka J, Sabóia LV, Fukujima G, Calder PC, Fernandes LCFish oil supplementation improves neutrophil function during cancer chemotherapyLipids.(2012 Apr)
-Kim SK, Demetri GDChemotherapy and neutropeniaHematol Oncol Clin North Am.(1996 Apr)
-Goldfarb Y, Shapiro H, Singer P, Kalderon Y, Levi B, Glasner A, Benish M, Ben-Eliyahu SFish oil attenuates surgery-induced immunosuppression, limits post-operative metastatic dissemination and increases long-term recurrence-free survival in rodents inoculated with cancer cellsClin Nutr.(2012 Jun)
-Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PCDietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 yAm J Clin Nutr.(2001 Mar)
-Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Ferretti A, Erickson KL, Yu R, Chandra RK, Mackey BEDocosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy menLipids.(1999 Apr)
-Miles EA, Banerjee T, Wells SJ, Calder PCLimited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young malesNutrition.(2006 May)
-Hall TJ, Chen SH, Brostoff J, Lydyard PMModulation of human natural killer cell activity by pharmacological mediatorsClin Exp Immunol.(1983 Nov)
-Interleukin-2 augments natural killer cell activity.()
-Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL, Lund FEReciprocal regulation of polarized cytokine production by effector B and T cellsNat Immunol.(2000 Dec)
-Lund FECytokine-producing B lymphocytes-key regulators of immunityCurr Opin Immunol.(2008 Jun)
-Rockett BD, Salameh M, Carraway K, Morrison K, Shaikh SRn-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivoJ Lipid Res.(2010 Jun)
-Rockett BD, Teague H, Harris M, Melton M, Williams J, Wassall SR, Shaikh SRFish oil increases raft size and membrane order of B cells accompanied by differential effects on functionJ Lipid Res.(2012 Apr)
-Gurzell EA, Teague H, Harris M, Clinthorne J, Shaikh SR, Fenton JIDHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell functionJ Leukoc Biol.(2013 Apr)
-Chambers CA, Allison JPCostimulatory regulation of T cell functionCurr Opin Cell Biol.(1999 Apr)
-Chapkin RS, Arrington JL, Apanasovich TV, Carroll RJ, McMurray DNDietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-culturesClin Exp Immunol.(2002 Oct)
-Arrington JL, Chapkin RS, Switzer KC, Morris JS, McMurray DNDietary n-3 polyunsaturated fatty acids modulate purified murine T-cell subset activationClin Exp Immunol.(2001 Sep)
-Ly LH, Smith R, Switzer KC, Chapkin RS, McMurray DNDietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cellsProstaglandins Leukot Essent Fatty Acids.(2006 Jan)
-Terada S, Takizawa M, Yamamoto S, Ezaki O, Itakura H, Akagawa KSSuppressive mechanisms of EPA on human T cell proliferationMicrobiol Immunol.(2001)
-Pompos LJ, Fritsche KLAntigen-driven murine CD4+ T lymphocyte proliferation and interleukin-2 production are diminished by dietary (n-3) polyunsaturated fatty acidsJ Nutr.(2002 Nov)
-Brix S, Lund P, Kjaer TM, Straarup EM, Hellgren LI, Frøkiaer HCD4(+) T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acidsImmunology.(2010 Mar)
-Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PCDietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humansJ Nutr.(2001 Jul)
-Kelley DS, Branch LB, Love JE, Taylor PC, Rivera YM, Iacono JMDietary alpha-linolenic acid and immunocompetence in humansAm J Clin Nutr.(1991 Jan)
-Peres CM, Otton R, Curi RModulation of lymphocyte proliferation by macrophages and macrophages loaded with arachidonic acidCell Biochem Funct.(2005 Nov-Dec)
-Nishiyama A, Cavaglieri CR, Curi R, Calder PCArachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytesBiochim Biophys Acta.(2000 Aug 24)
-Das UNBeneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine networkProstaglandins Leukot Essent Fatty Acids.(1994 Sep)

🦠🔴 Імунітет, рак, пухлини, онкозахворювання (шкіра, підшлункова, передміхурова, тощо) - 13 досліджень [425-438]:
-Hakim IA, Harris RB, Ritenbaugh CFat intake and risk of squamous cell carcinoma of the skinNutr Cancer.(2000)
-Kune GA, Bannerman S, Field B, Watson LF, Cleland H, Merenstein D, Vitetta LDiet, alcohol, smoking, serum beta-carotene, and vitamin A in male nonmelanocytic skin cancer patients and controlsNutr Cancer.(1992)
-Wallingford SC, van As JA, Hughes MC, Ibiebele TI, Green AC, van der Pols JCIntake of omega-3 and omega-6 fatty acids and risk of basal and squamous cell carcinomas of the skin: a longitudinal community-based study in Australian adultsNutr Cancer.(2012)
-Fischer MA, Black HSModification of membrane composition, eicosanoid metabolism, and immunoresponsiveness by dietary omega-3 and omega-6 fatty acid sources, modulators of ultraviolet-carcinogenesisPhotochem Photobiol.(1991 Sep)
-Pilkington SM, Massey KA, Bennett SP, Al-Aasswad NM, Roshdy K, Gibbs NK, Friedmann PS, Nicolaou A, Rhodes LERandomized controlled trial of oral omega-3 PUFA in solar-simulated radiation-induced suppression of human cutaneous immune responsesAm J Clin Nutr.(2013 Mar)
-Lou YR, Peng QY, Li T, Medvecky CM, Lin Y, Shih WJ, Conney AH, Shapses S, Wagner GC, Lu YPEffects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 miceCarcinogenesis.(2011 Jul)
-Black HS, Thornby JI, Gerguis J, Lenger WInfluence of dietary omega-6, -3 fatty acid sources on the initiation and promotion stages of photocarcinogenesisPhotochem Photobiol.(1992 Aug)
-Orengo IF, Black HS, Kettler AH, Wolf JE JrInfluence of dietary menhaden oil upon carcinogenesis and various cutaneous responses to ultraviolet radiationPhotochem Photobiol.(1989 Jan)
-Ziboh VA, Miller CCEssential fatty acids and polyunsaturated fatty acids: significance in cutaneous biologyAnnu Rev Nutr.(1990)
-Reeve VE, Bosnic M, Boehm-Wilcox CDependence of photocarcinogenesis and photoimmunosuppression in the hairless mouse on dietary polyunsaturated fatCancer Lett.(1996 Nov 29)
-Fukui M, Kang KS, Okada K, Zhu BTEPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy inductionJ Cell Biochem.(2013 Jan)
-Lucia MS, Torkko KCInflammation as a target for prostate cancer chemoprevention: pathological and laboratory rationaleJ Urol.(2004 Feb)
-Chavarro JE, Stampfer MJ, Li H, Campos H, Kurth T, Ma JA prospective study of polyunsaturated fatty acid levels in blood and prostate cancer riskCancer Epidemiol Biomarkers Prev.(2007 Jul)

💪🏋️‍♂️ Спортивні показники, м'язи, гіпертрофія, сила, витривалість, зниження імунітету, повязаного з фізичними вправами - 28 досліджень [425-466]:
- Warner JG Jr, Ullrich IH, Albrink MJ, Yeater RACombined effects of aerobic exercise and omega-3 fatty acids in hyperlipidemic personsMed Sci Sports Exerc.(1989 Oct)
- Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer BOmega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and womenClin Sci (Lond).(2011 Sep)
- Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer BDietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trialAm J Clin Nutr.(2011 Feb)
- An WS, Kim HJ, Cho KH, Vaziri NDOmega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidneyAm J Physiol Renal Physiol.(2009 Oct)
- Chen J, Shearer GC, Chen Q, Healy CL, Beyer AJ, Nareddy VB, Gerdes AM, Harris WS, O’Connell TD, Wang DOmega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblastsCirculation.(2011 Feb)
- McGlory C, Wardle SL, Macnaughton LS, Witard OC, Scott F, Dick J, Bell JG, Phillips SM, Galloway SD, Hamilton DL, Tipton KDFish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young menPhysiol Rep.(2016 Mar)
- Yamazaki RK, Brito GA, Coelho I, Pequitto DC, Yamaguchi AA, Borghetti G, Schiessel DL, Kryczyk M, Machado J, Rocha RE, Aikawa J, Iagher F, Naliwaiko K, Tanhoffer RA, Nunes EA, Fernandes LCLow fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese ratsLipids Health Dis.(2011 Apr 28)
- Lam YY, Hatzinikolas G, Weir JM, Janovská A, McAinch AJ, Game P, Meikle PJ, Wittert GAInsulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acidsBiochim Biophys Acta.(2011 Jul-Aug)
- Delarue J, Li CH, Cohen R, Corporeau C, Simon BInteraction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjectsBr J Nutr.(2006 Feb)
- Cha SH, Fukushima A, Sakuma K, Kagawa YChronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl miceJ Nutr.(2001 Oct)
- Perez R, Canón J, Dunner SGenes associated with long-chain omega-3 fatty acids in bovine skeletal muscleJ Appl Genet.(2010)
- Hessvik NP, Bakke SS, Fredriksson K, Boekschoten MV, Fjørkenstad A, Koster G, Hesselink MK, Kersten S, Kase ET, Rustan AC, Thoresen GHMetabolic switching of human myotubes is improved by n-3 fatty acidsJ Lipid Res.(2010 Aug)
- You JS, Park MN, Song W, Lee YSDietary fish oil alleviates soleus atrophy during immobilization in association with Akt signaling to p70s6k and E3 ubiquitin ligases in ratsAppl Physiol Nutr Metab.(2010 Jun)
- You JS, Park MN, Lee YSDietary fish oil inhibits the early stage of recovery of atrophied soleus muscle in rats via Akt-p70s6k signaling and PGF2αJ Nutr Biochem.(2010 Oct)
- Ryan AM, Reynolds JV, Healy L, Byrne M, Moore J, Brannelly N, McHugh A, McCormack D, Flood PEnteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trialAnn Surg.(2009 Mar)
- Read JA, Beale PJ, Volker DH, Smith N, Childs A, Clarke SJNutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trialSupport Care Cancer.(2007 Mar)
- Fearon KC, Von Meyenfeldt MF, Moses AG, Van Geenen R, Roy A, Gouma DJ, Giacosa A, Van Gossum A, Bauer J, Barber MD, Aaronson NK, Voss AC, Tisdale MJEffect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trialGut.(2003 Oct)
- Tishinsky JM, Gulli RA, Mullen KL, Dyck DJ, Robinson LEFish oil prevents high saturated fat diet-induced impairments in adiponectin and insulin response in rodent soleus muscleAm J Physiol Regul Integr Comp Physiol.(2011 Dec 28)
- Guebre-Egziabher F, Rabasa-Lhoret R, Bonnet F, Bastard JP, Desage M, Skilton MR, Vidal H, Laville MNutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjectsEur J Clin Nutr.(2008 Nov)
- Aas V, Rokling-Andersen MH, Kase ET, Thoresen GH, Rustan ACEicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cellsJ Lipid Res.(2006 Feb)
- Abbott SK, Else PL, Hulbert AJMembrane fatty acid composition of rat skeletal muscle is most responsive to the balance of dietary n-3 and n-6 PUFABr J Nutr.(2010 Feb)
- Haugaard SB, Vaag A, Mu H, Madsbad SSkeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary interventionLipids Health Dis.(2009 Aug 13)
 - Gray P, Gabriel B, Thies F, Gray SRFish oil supplementation augments post-exercise immune function in young malesBrain Behav Immun.(2012 Nov)
 - Pedersen BK, Tvede N, Hansen FR, Andersen V, Bendix T, Bendixen G, Bendtzen K, Galbo H, Haahr PM, Klarlund K, et alModulation of natural killer cell activity in peripheral blood by physical exerciseScand J Immunol.(1988 Jun)
 - Pedersen BK, Tvede N, Klarlund K, Christensen LD, Hansen FR, Galbo H, Kharazmi A, Halkjaer-Kristensen JIndomethacin in vitro and in vivo abolishes post-exercise suppression of natural killer cell activity in peripheral bloodInt J Sports Med.(1990 Apr)
 - Bloomer RJ, Larson DE, Fisher-Wellman KH, Galpin AJ, Schilling BKEffect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over studyLipids Health Dis.(2009 Aug 19)
 - Hall TJ, Chen SH, Brostoff J, Lydyard PMModulation of human natural killer cell activity by pharmacological mediatorsClin Exp Immunol.(1983 Nov)
 - Interleukin-2 augments natural killer cell activity.()

👓👁️ Зір, очі, офтальмологія - 9 досліджень [466-475]:
-Montori VM, Farmer A, Wollan PC, Dinneen SFFish oil supplementation in type 2 diabetes: a quantitative systematic reviewDiabetes Care.(2000 Sep)
-Friedberg CE, Janssen MJ, Heine RJ, Grobbee DEFish oil and glycemic control in diabetes. A meta-analysisDiabetes Care.(1998 Apr)
-MacLean CH, Mojica WA, Morton SC, Pencharz J, Hasenfeld Garland R, Tu W, Newberry SJ, Jungvig LK, Grossman J, Khanna P, Rhodes S, Shekelle PEffects of omega-3 fatty acids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosisEvid Rep Technol Assess (Summ).(2004 Mar)
-Hartweg J, Perera R, Montori V, Dinneen S, Neil HA, Farmer AOmega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitusCochrane Database Syst Rev.(2008 Jan 23)
-546.^SanGiovanni JP, Chew EYThe role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retinaProg Retin Eye Res.(2005 Jan)
-547.^Futterman S, Kupfer CThe fatty acid composition of the retinal vasculature of normal and diabetic human eyesInvest Ophthalmol.(1968 Feb)
-548.^Tikhonenko M, Lydic TA, Wang Y, Chen W, Opreanu M, Sochacki A, McSorley KM, Renis RL, Kern T, Jump DB, Reid GE, Busik JVRemodeling of retinal Fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4Diabetes.(2010 Jan)
-549.^Decsi T, Minda H, Hermann R, Kozári A, Erhardt E, Burus I, Molnár S, Soltész GPolyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic childrenProstaglandins Leukot Essent Fatty Acids.(2002 Oct)
-550.^Tikhonenko M, Lydic TA, Opreanu M, Li Calzi S, Bozack S, McSorley KM, Sochacki AL, Faber MS, Hazra S, Duclos S, Guberski D, Reid GE, Grant MB, Busik JVN-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative functionPLoS One.(2013)

🍽️ Підшлункова залоза - 19 досліджень [475-494]:
-Opreanu M, Tikhonenko M, Bozack S, Lydic TA, Reid GE, McSorley KM, Sochacki A, Perez GI, Esselman WJ, Kern T, Kolesnick R, Grant MB, Busik JVThe unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal modelsDiabetes.(2011 Sep)
-Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N Jr, Serhan CN, Smith LEIncreased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisNat Med.(2007 Jul)
-Kang JX, Wang J, Wu L, Kang ZBTransgenic mice: fat-1 mice convert n-6 to n-3 fatty acidsNature.(2004 Feb 5)
-Henquin JCTriggering and amplifying pathways of regulation of insulin secretion by glucoseDiabetes.(2000 Nov)
-McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett JACytokines and nitric oxide in islet inflammation and diabetesProc Soc Exp Biol Med.(1996 Jan)
-Luo P, Wang MHEicosanoids, β-cell function, and diabetesProstaglandins Other Lipid Mediat.(2011 Aug)
-Tran PO, Gleason CE, Robertson RPInhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell functionDiabetes.(2002 Jun)
-Robertson RPArachidonic acid metabolite regulation of insulin secretionDiabetes Metab Rev.(1986)
-Fujita H, Kakei M, Fujishima H, Morii T, Yamada Y, Qi Z, Breyer MDEffect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 miceBiochem Biophys Res Commun.(2007 Nov 9)
-Robertson RPDominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesisDiabetes.(1998 Sep)
-Tran PO, Gleason CE, Poitout V, Robertson RPProstaglandin E(2) mediates inhibition of insulin secretion by interleukin-1betaJ Biol Chem.(1999 Oct 29)
-Persaud SJ, Muller D, Belin VD, Kitsou-Mylona I, Asare-Anane H, Papadimitriou A, Burns CJ, Huang GC, Amiel SA, Jones PMThe role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhansDiabetes.(2007 Jan)
-Oshima H, Taketo MM, Oshima MDestruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the isletsJ Biol Chem.(2006 Sep 29)
-Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, Nadler JLFunctional and pathological roles of the 12- and 15-lipoxygenasesProg Lipid Res.(2011 Jan)
-Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DAIntegration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunctionMol Cell Endocrinol.(2012 Jul)
-Metz SA, Murphy RC, Fujimoto WEffects on glucose-induced insulin secretion of lipoxygenase-derived metabolites of arachidonic acidDiabetes.(1984 Feb)
-Ma K, Nunemaker CS, Wu R, Chakrabarti SK, Taylor-Fishwick DA, Nadler JL12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human IsletsJ Clin Endocrinol Metab.(2010 Feb)
-Wei D, Li J, Shen M, Jia W, Chen N, Chen T, Su D, Tian H, Zheng S, Dai Y, Zhao ACellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell deathDiabetes.(2010 Feb)
-Bellenger J, Bellenger S, Bataille A, Massey KA, Nicolaou A, Rialland M, Tessier C, Kang JX, Narce MHigh pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibitionDiabetes.(2011 Apr)

🚰 Нирки - 5 досліджень [494-499]:
-Wong CY, Yiu KH, Li SW, Lee S, Tam S, Lau CP, Tse HFFish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitusDiabet Med.(2010 Jan)
-Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric COmega-3 fatty acid rich diet prevents diabetic renal diseaseAm J Physiol Renal Physiol.(2009 Feb)
-Logan JL, Benson B, Lee SMDietary fish oil enhances renal hypertrophy in experimental diabetesDiabetes Res Clin Pract.(1990 Oct)
-Hagiwara S, Makita Y, Gu L, Tanimoto M, Zhang M, Nakamura S, Kaneko S, Itoh T, Gohda T, Horikoshi S, Tomino YEicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylationNephrol Dial Transplant.(2006 Mar)
-Shapiro H, Theilla M, Attal-Singer J, Singer PEffects of polyunsaturated fatty acid consumption in diabetic nephropathyNat Rev Nephrol.(2011 Feb)

🧠🤯 Синдром дефіциту уваги та гіперактивності (СДВГ) - 14 досліджень [499-513]:
-Voigt RG, Llorente AM, Jensen CL, Fraley JK, Berretta MC, Heird WCA randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorderJ Pediatr.(2001 Aug)
-Richardson AJ, Puri BKA randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficultiesProg Neuropsychopharmacol Biol Psychiatry.(2002 Feb)
-Stevens L, Zhang W, Peck L, Kuczek T, Grevstad N, Mahon A, Zentall SS, Arnold LE, Burgess JREFA supplementation in children with inattention, hyperactivity, and other disruptive behaviorsLipids.(2003 Oct)
-Sinn N, Bryan JEffect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHDJ Dev Behav Pediatr.(2007 Apr)
-Bélanger SA, Vanasse M, Spahis S, Sylvestre MP, Lippé S, L'heureux F, Ghadirian P, Vanasse CM, Levy EOmega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled studyPaediatr Child Health.(2009 Feb)
-Bos DJ, Oranje B, Veerhoek ES, Van Diepen RM, Weusten JM, Demmelmair H, Koletzko B, de Sain-van der Velden MG, Eilander A, Hoeksma M, Durston SReduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity DisorderNeuropsychopharmacology.(2015 Sep)
-Widenhorn-Müller K, Schwanda S, Scholz E, Spitzer M, Bode HEffect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trialProstaglandins Leukot Essent Fatty Acids.(2014 Jul-Aug)
-Gustafsson PA, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H, Strandvik B, Karlsson TEPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHDActa Paediatr.(2010 Oct)
-Bloch MH, Qawasmi AOmega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysisJ Am Acad Child Adolesc Psychiatry.(2011 Oct)
-Gillies D, Sinn JKh, Lad SS, Leach MJ, Ross MJPolyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescentsCochrane Database Syst Rev.(2012 Jul 11)
-Aman MG, Mitchell EA, Turbott SHThe effects of essential fatty acid supplementation by Efamol in hyperactive childrenJ Abnorm Child Psychol.(1987 Mar)
-Arnold LE, Kleykamp D, Votolato NA, Taylor WA, Kontras SB, Tobin KGamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamineBiol Psychiatry.(1989 Jan 15)
-Raz R, Carasso RL, Yehuda SThe influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled studyJ Child Adolesc Psychopharmacol.(2009 Apr)
-Hirayama S, Hamazaki T, Terasawa KEffect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind studyEur J Clin Nutr.(2004 Mar)

🐺🔴 Червона вовчанка - 14 досліджень [513-527]:
-Wright SA, O'Prey FM, McHenry MT, Leahey WJ, Devine AB, Duffy EM, Johnston DG, Finch MB, Bell AL, McVeigh GEA randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosusAnn Rheum Dis.(2008 Jun)
-Duffy EM, Meenagh GK, McMillan SA, Strain JJ, Hannigan BM, Bell ALThe clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosusJ Rheumatol.(2004 Aug)
-Ilowite NT, Copperman N, Leicht T, Kwong T, Jacobson MSEffects of dietary modification and fish oil supplementation on dyslipoproteinemia in pediatric systemic lupus erythematosusJ Rheumatol.(1995 Jul)
-Prickett JD, Robinson DR, Steinberg ADDietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 miceJ Clin Invest.(1981 Aug)
-Robinson DR, Prickett JD, Polisson R, Steinberg AD, Levine LThe protective effect of dietary fish oil on murine lupusProstaglandins.(1985 Jul)
-Clark WF, Parbtani A, Naylor CD, Levinton CM, Muirhead N, Spanner E, Huff MW, Philbrick DJ, Holub BJFish oil in lupus nephritis: clinical findings and methodological implicationsKidney Int.(1993 Jul)
- Westberg G, Tarkowski AEffect of MaxEPA in patients with SLE. A double-blind, - - Walton AJ, Snaith ML, Locniskar M, Cumberland AG, Morrow WJ, Isenberg DADietary fish oil and the severity of symptoms in patients with systemic lupus erythematosusAnn Rheum Dis.(1991 Jul)

👨‍👩‍👦 Репродуктивність, здатність до зачаття, фертильність - 5 досліджень [527-532]:
- Bernstein LR, Mackenzie AC, Kraemer DC, Morley JE, Farr S, Chaffin CL, Merchenthaler IShortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive agingEndocrinology.(2014 Jun)
- Klein NA, Battaglia DE, Fujimoto VY, Davis GS, Bremner WJ, Soules MRReproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older womenJ Clin Endocrinol Metab.(1996 Mar)
- Lee SJ, Lenton EA, Sexton L, Cooke IDThe effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cyclesHum Reprod.(1988 Oct)
- Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder MProlonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acidsAging Cell.(2012 Dec)
- Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJOmega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese WomenJ Clin Endocrinol Metab.(2016 Jan)

🤰🤱 Вагітність, материнство, годування груддю, лактація, розвиток дітей - 36 досліджень [532-568]:
- Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation.()
- Mozurkewich EL, Clinton CM, Chilimigras JL, Hamilton SE, Allbaugh LJ, Berman DR, Marcus SM, Romero VC, Treadwell MC, Keeton KL, Vahratian AM, Schrader RM, Ren J, Djuric ZThe Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trialAm J Obstet Gynecol.(2013 Apr)
- Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P; DOMInO Investigative TeamEffect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trialJAMA.(2010 Oct 20)
- Metzger BE, Coustan DRSummary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing CommitteeDiabetes Care.(1998 Aug)
- Wang Y, Storlien LH, Jenkins AB, Tapsell LC, Jin Y, Pan JF, Shao YF, Calvert GD, Moses RG, Shi HL, Zhu XXDietary variables and glucose tolerance in pregnancyDiabetes Care.(2000 Apr)
- Bo S, Menato G, Lezo A, Signorile A, Bardelli C, De Michieli F, Massobrio M, Pagano GDietary fat and gestational hyperglycaemiaDiabetologia.(2001 Aug)
- Radesky JS, Oken E, Rifas-Shiman SL, Kleinman KP, Rich-Edwards JW, Gillman MWDiet during early pregnancy and development of gestational diabetesPaediatr Perinat Epidemiol.(2008 Jan)
- Zhou SJ, Yelland L, McPhee AJ, Quinlivan J, Gibson RA, Makrides MFish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsiaAm J Clin Nutr.(2012 Jun)
- Friedman SAPreeclampsia: a review of the role of prostaglandinsObstet Gynecol.(1988 Jan)
- Pedersen EB, Christensen NJ, Christensen P, Johannesen P, Kornerup HJ, Kristensen S, Lauritsen JG, Leyssac PP, Rasmussen AB, Wohlert MProstaglandins, renin, aldosterone, and catecholamines in preeclampsiaActa Med Scand Suppl.(1983)
- Makrides M, Duley L, Olsen SFMarine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restrictionCochrane Database Syst Rev.(2006 Jul 19)
- Olsen SF, Sørensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS, Grant ARandomised controlled trial of effect of fish-oil supplementation on pregnancy durationLancet.(1992 Apr 25)
- Koletzko B, Larqué E, Demmelmair HPlacental transfer of long-chain polyunsaturated fatty acids (LC-PUFA)J Perinat Med.(2007)
- Hanebutt FL, Demmelmair H, Schiessl B, Larqué E, Koletzko BLong-chain polyunsaturated fatty acid (LC-PUFA) transfer across the placentaClin Nutr.(2008 Oct)
- Larqué E, Krauss-Etschmann S, Campoy C, Hartl D, Linde J, Klingler M, Demmelmair H, Caño A, Gil A, Bondy B, Koletzko BDocosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteinsAm J Clin Nutr.(2006 Oct)
- Larque E, Demmelmair H, Koletzko BPerinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous systemAnn N Y Acad Sci.(2002 Jun)
- Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JTFetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer studyJ Lipid Res.(2001 Apr)
- Makrides M, Neumann MA, Byard RW, Simmer K, Gibson RAFatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infantsAm J Clin Nutr.(1994 Aug)
- Gould JF, Smithers LG, Makrides MThe effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trialsAm J Clin Nutr.(2013 Mar)
- Dunstan JA, Simmer K, Dixon G, Prescott SLCognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trialArch Dis Child Fetal Neonatal Ed.(2008 Jan)
- van Goor SA, Dijck-Brouwer DA, Doornbos B, Erwich JJ, Schaafsma A, Muskiet FA, Hadders-Algra MSupplementation of DHA but not DHA with arachidonic acid during pregnancy and lactation influences general movement quality in 12-week-old term infantsBr J Nutr.(2010 Jan)
- Tofail F, Kabir I, Hamadani JD, Chowdhury F, Yesmin S, Mehreen F, Huda SNSupplementation of fish-oil and soy-oil during pregnancy and psychomotor development of infantsJ Health Popul Nutr.(2006 Mar)
- Helland IB, Saugstad OD, Smith L, Saarem K, Solvoll K, Ganes T, Drevon CASimilar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating womenPediatrics.(2001 Nov)
- Innis SM, Friesen RWEssential n-3 fatty acids in pregnant women and early visual acuity maturation in term infantsAm J Clin Nutr.(2008 Mar)
- Decsi T, Campoy C, Koletzko BEffect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trialAdv Exp Med Biol.(2005)
- Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial.()
- Impact of maternal docosahexaenoic acid (DHA) supplementation in the form of a functional food during pregnancy on infant neurodevelopment: A comparison of vision, memory, temperament and problem-solving abilities.()
- Farquharson J, Cockburn F, Patrick WA, Jamieson EC, Logan RWInfant cerebral cortex phospholipid fatty-acid composition and dietLancet.(1992 Oct 3)
- Jamieson EC, Farquharson J, Logan RW, Howatson AG, Patrick WJ, Weaver LT, Cockburn FInfant cerebellar gray and white matter fatty acids in relation to age and dietLipids.(1999 Oct)
- Lapillonne A, Groh-Wargo S, Gonzalez CH, Uauy RLipid needs of preterm infants: updated recommendationsJ Pediatr.(2013 Mar)
- Straarup EM, Lauritzen L, Faerk J, Høy Deceased CE, Michaelsen KFThe stereospecific triacylglycerol structures and Fatty Acid profiles of human milk and infant formulasJ Pediatr Gastroenterol Nutr.(2006 Mar)
- Makrides M, Neumann MA, Gibson RAEffect of maternal docosahexaenoic acid (DHA) supplementation on breast milk compositionEur J Clin Nutr.(1996 Jun)
- Boris J, Jensen B, Salvig JD, Secher NJ, Olsen SFA randomized controlled trial of the effect of fish oil supplementation in late pregnancy and early lactation on the n-3 fatty acid content in human breast milkLipids.(2004 Dec)
- The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n–3 fatty acid intake, and marine n–3 fatty acid status in maternal and umbilical cord blood.()
- Makrides M, Simmer K, Neumann M, Gibso

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.3):

🥗🤩 Схуднення, зменшення ваги, жироспалювання, зайва вага, контроль апетиту - 30 досліджень [568-598]:
- Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, Ruzickova J, Sponarova J, Drahota Z, Vlcek C, Keijer J, Houstek J, Kopecky JPolyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fatDiabetologia.(2005 Nov)
- Kelly DP, Scarpulla RCTranscriptional regulatory circuits controlling mitochondrial biogenesis and functionGenes Dev.(2004 Feb 15)
- Rufer AC, Thoma R, Hennig MStructural insight into function and regulation of carnitine palmitoyltransferaseCell Mol Life Sci.(2009 Aug)
- Nakatani T, Tsuboyama-Kasaoka N, Takahashi M, Miura S, Ezaki OMechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytesJ Biol Chem.(2002 Mar 15)
- Tsuboyama-Kasaoka N, Takahashi M, Kim H, Ezaki OUp-regulation of liver uncoupling protein-2 mRNA by either fish oil feeding or fibrate administration in miceBiochem Biophys Res Commun.(1999 Apr 21)
- Kunesová M, Braunerová R, Hlavatý P, Tvrzická E, Stanková B, Skrha J, Hilgertová J, Hill M, Kopecký J, Wagenknecht M, Hainer V, Matoulek M, Parízková J, Zák A, Svacina SThe influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese womenPhysiol Res.(2006)
- Couet C, Delarue J, Ritz P, Antoine JM, Lamisse FEffect of dietary fish oil on body fat mass and basal fat oxidation in healthy adultsInt J Obes Relat Metab Disord.(1997 Aug)
- Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulangé A, Vidal H, Slama G, Clément K, Guerre-Millo M, Rizkalla SWTreatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled studyAm J Clin Nutr.(2007 Dec)
- Neschen S, Morino K, Rossbacher JC, Pongratz RL, Cline GW, Sono S, Gillum M, Shulman GIFish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in miceDiabetes.(2006 Apr)
- Shirai N, Suzuki HEffects of simultaneous intakes of fish oil and green tea extracts on plasma, glucose, insulin, C-peptide, and adiponectin and on liver lipid concentrations in mice fed low- and high-fat dietsAnn Nutr Metab.(2008)
- Gammelmark A, Madsen T, Varming K, Lundbye-Christensen S, Schmidt EBLow-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjectsNutr Res.(2012 Jan)
- Flachs P, Mohamed-Ali V, Horakova O, Rossmeisl M, Hosseinzadeh-Attar MJ, Hensler M, Ruzickova J, Kopecky JPolyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat dietDiabetologia.(2006 Feb)
- Tishinsky JM, Ma DW, Robinson LEEicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytesObesity (Silver Spring).(2011 Feb)
- Rossi AS, Lombardo YB, Lacorte JM, Chicco AG, Rouault C, Slama G, Rizkalla SWDietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant ratsAm J Physiol Regul Integr Comp Physiol.(2005 Aug)
- Todoric J, Löffler M, Huber J, Bilban M, Reimers M, Kadl A, Zeyda M, Waldhäusl W, Stulnig TMAdipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acidsDiabetologia.(2006 Sep)
- Ma T, Liaset B, Hao Q, Petersen RK, Fjære E, Ngo HT, Lillefosse HH, Ringholm S, Sonne SB, Treebak JT, Pilegaard H, Frøyland L, Kristiansen K, Madsen LSucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in micePLoS One.(2011)
- Baillie RA, Takada R, Nakamura M, Clarke SDCoordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat depositionProstaglandins Leukot Essent Fatty Acids.(1999 May-Jun)
- Belzung F, Raclot T, Groscolas RFish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat depots in growing rats fed high-fat dietsAm J Physiol.(1993 Jun)
- Hainault I, Carolotti M, Hajduch E, Guichard C, Lavau MFish oil in a high lard diet prevents obesity, hyperlipemia, and adipocyte insulin resistance in ratsAnn N Y Acad Sci.(1993 Jun 14)
- Parrish CC, Pathy DA, Angel ADietary fish oils limit adipose tissue hypertrophy in ratsMetabolism.(1990 Mar)
- Pérez-Matute P, Pérez-Echarri N, Martínez JA, Marti A, Moreno-Aliaga MJEicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alphaBr J Nutr.(2007 Feb)
- Ruzickova J, Rossmeisl M, Prazak T, Flachs P, Sponarova J, Veck M, Tvrzicka E, Bryhn M, Kopecky JOmega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissueLipids.(2004 Dec)
- Huang XF, Xin X, McLennan P, Storlien LRole of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expressionDiabetes Obes Metab.(2004 Jan)
- Buckley JD, Howe PRAnti-obesity effects of long-chain omega-3 polyunsaturated fatty acidsObes Rev.(2009 Nov)
- Lorente-Cebrián S, Pérez-Matute P, Martínez JA, Marti A, Moreno-Aliaga MJEffects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytesJ Physiol Biochem.(2006 Jun)
- Dietary Fatty Acids Influence the Activity and Metabolic Control of Mitochondrial Carnitine Palmitoyltransferase I in Rat Heart and Skeletal Muscle.()
- Mascaró C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, Haro DControl of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptorJ Biol Chem.(1998 Apr 10)
- Fish consumption and risk of stroke in man.()
- Iso H, Rexrode KM, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Hennekens CH, Willett WCIntake of fish and omega-3 fatty acids and risk of stroke in womenJAMA.(2001 Jan 17)
- Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors.()

💆‍♀️💅💄 Естетика, жіноча краса (шкіра, волосся, нігті) - 13 досліджень [598-611]:
-Rhodes LE, O'Farrell S, Jackson MJ, Friedmann PSDietary fish-oil supplementation in humans reduces UVB-erythemal sensitivity but increases epidermal lipid peroxidationJ Invest Dermatol.(1994 Aug)
-Rhodes LE, Shahbakhti H, Azurdia RM, Moison RM, Steenwinkel MJ, Homburg MI, Dean MP, McArdle F, Beijersbergen van Henegouwen GM, Epe B, Vink AAEffect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markersCarcinogenesis.(2003 May)
-Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.()
-Damian DL, Barnetson RS, Halliday GMEffects of low-dose ultraviolet radiation on in vivo human cutaneous recall responsesAustralas J Dermatol.(2001 Aug)
-Sivapirabu G, Yiasemides E, Halliday GM, Park J, Damian DLTopical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humansBr J Dermatol.(2009 Dec)
-Noonan FP, De Fabo EC, Kripke MLSuppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunityPhotochem Photobiol.(1981 Dec)
-Theilla M, Singer P, Cohen J, Dekeyser FA diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled studyClin Nutr.(2007 Dec)
-Singer P, Theilla M, Fisher H, Gibstein L, Grozovski E, Cohen JBenefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injuryCrit Care Med.(2006 Apr)
-Theilla M, Schwartz B, Zimra Y, Shapiro H, Anbar R, Rabizadeh E, Cohen J, Singer PEnteral n-3 fatty acids and micronutrients enhance percentage of positive neutrophil and lymphocyte adhesion molecules: a potential mediator of pressure ulcer healing in critically ill patientsBr J Nutr.(2012 Apr)
-Theilla M, Schwartz B, Cohen J, Shapiro H, Anbar R, Singer PImpact of a nutritional formula enriched in fish oil and micronutrients on pressure ulcers in critical care patientsAm J Crit Care.(2012 Jul)
-Fish-oil-rich diet lowers bedsore symptoms by 20-25%.()
-Colombe L, Vindrios A, Michelet JF, Bernard BAProstaglandin metabolism in human hair follicleExp Dermatol.(2007 Sep)
-Yamamoto K, Taketomi Y, Isogai Y, Miki Y, Sato H, Masuda S, Nishito Y, Morioka K, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Ishikawa Y, Ishii T, Kobayashi T, Fuk

👇 Взаємодія з іншими речовинами:

🌿💊 Куркумін (турмерік), Активатор-Жироспалювач - 8 досліджень [611-619]:
-Altenburg JD, Bieberich AA, Terry C, Harvey KA, Vanhorn JF, Xu Z, Jo Davisson V, Siddiqui RAA synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound aloneBMC Cancer.(2011 Apr 21)
-Saw CL, Huang Y, Kong ANSynergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acidBiochem Pharmacol.(2010 Feb 1)
-Jia Q, Ivanov I, Zlatev ZZ, Alaniz RC, Weeks BR, Callaway ES, Goldsby JS, Davidson LA, Fan YY, Zhou L, Lupton JR, McMurray DN, Chapkin RSDietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated miceBr J Nutr.(2011 Aug)
-Zuccato C, Cattaneo EBrain-derived neurotrophic factor in neurodegenerative diseasesNat Rev Neurol.(2009 Jun)
-Nagappan G, Lu BActivity-dependent modulation of the BDNF receptor TrkB: mechanisms and implicationsTrends Neurosci.(2005 Sep)
-Suzuki H, Park SJ, Tamura M, Ando SEffect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil dietMech Ageing Dev.(1998 Mar 16)
-Wu A, Ying Z, Gomez-Pinilla FDocosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognitionNeuroscience.(2008 Aug 26)
-Wu A, Ying Z, Gomez-Pinilla FDietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognitionExp Neurol.(2006 Feb)

🚫💊 Дослідження шкоди поєднання Омега-3 та Омега-6 - 3 дослідження [619-622]:
 - Damsgaard CT, Frøkiaer H, Andersen AD, Lauritzen LFish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy menJ Nutr.(2008 Jun)
 - Sofi F, Giorgi G, Cesari F, Gori AM, Mannini L, Parisi G, Casini A, Abbate R, Gensini GF, Poli BMThe atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratioAsia Pac J Clin Nutr.(2013)
 - Damsgaard CT, Frøkiaer H, Lauritzen LThe effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cellsBr J Nutr.(2008 Jan)

🌿💊 Таурін - 1 досліджень [622-623]:
 - Mikami N, Hosokawa M, Miyashita KDietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(y) miceJ Food Sci.(2012 Jun)

🌿💊 Статини (препарати від атеросклерозу) - 9 досліджень [623-632]:
-Nozue T, Yamamoto S, Tohyama S, Fukui K, Umezawa S, Onishi Y, Kunishima T, Sato A, Nozato T, Miyake S, Takeyama Y, Morino Y, Yamauchi T, Muramatsu T, Hibi K, Terashima M, Michishita IEffects of serum n-3 to n-6 polyunsaturated fatty acids ratios on coronary atherosclerosis in statin-treated patients with coronary artery diseaseAm J Cardiol.(2013 Jan 1)
-Lee SP, Dart AM, Walker KZ, O'Dea K, Chin-Dusting JP, Skilton MREffect of altering dietary n-6:n-3 PUFA ratio on cardiovascular risk measures in patients treated with statins: a pilot studyBr J Nutr.(2012 Oct)
-Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PNEfficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)Am J Cardiol.(2012 Oct 1)
-Vecka M, Dušejovská M, Stankova B, Zeman M, Vavrova L, Kodydkova J, Slaby A, Zak AN-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemiaNeuro Endocrinol Lett.(2012)
-Sasaki J, Miwa T, Odawara MAdministration of highly purified eicosapentaenoic acid to statin-treated diabetic patients further improves vascular functionEndocr J.(2012)
-Becker DJ, Gordon RY, Morris PB, Yorko J, Gordon YJ, Li M, Iqbal NSimvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trialMayo Clin Proc.(2008 Jul)
-Agouridis AP, Tsimihodimos V, Filippatos TD, Dimitriou AA, Tellis CC, Elisaf MS, Mikhailidis DP, Tselepis ADThe effects of rosuvastatin alone or in combination with fenofibrate or omega 3 fatty acids on inflammation and oxidative stress in patients with mixed dyslipidemiaExpert Opin Pharmacother.(2011 Dec)
-Agouridis AP, Kostapanos MS, Tsimihodimos V, Kostara C, Mikhailidis DP, Bairaktari ET, Tselepis AD, Elisaf MSEffect of rosuvastatin monotherapy or in combination with fenofibrate or ω-3 fatty acids on lipoprotein subfraction profile in patients with mixed dyslipidaemia and metabolic syndromeInt J Clin Pract.(2012 Sep)
-Agouridis AP, Tsimihodimos V, Filippatos TD, Tselepis AD, Elisaf MSHigh doses of rosuvastatin are superior to low doses of rosuvastatin plus fenof

🌿💊 Фукоксантин - 1 дослідження [632-633]:
 - Maeda H, Hosokawa M, Sashima T, Miyashita KDietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay miceJ Agric Food Chem.(2007 Sep 19)

🌿💊 Пажитник - 1 дослідження [633-634]:
 - Hamden K, Keskes H, Belhaj S, Mnafgui K, Feki A, Allouche NInhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes ratsLipids Health Dis.(2011 Dec 5)

🌿💊 Уридин - 5 досліджень [634-639]:
-Sastry PSLipids of nervous tissue: composition and metabolismProg Lipid Res.(1985)
-Cansev MUridine and cytidine in the brain: their transport and utilizationBrain Res Rev.(2006 Sep)
-Ross BM, Moszczynska A, Blusztajn JK, Sherwin A, Lozano A, Kish SJPhospholipid biosynthetic enzymes in human brainLipids.(1997 Apr)
-Wurtman RJ, Cansev M, Ulus IHSynapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatidesJ Nutr Health Aging.(2009 Mar)
-Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff GSynaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orallyBrain Res.(2006 May 9)

🌿💊 Астаксантин - 3 дослідження [639-642]:
 - Otton R, Marin DP, Bolin AP, de Cássia Santos Macedo R, Campoio TR, Fineto C Jr, Guerra BA, Leite JR, Barros MP, Mattei RCombined fish oil and astaxanthin supplementation modulates rat lymphocyte functionEur J Nutr.(2012 Sep)
 - Bolin AP, Macedo RC, Marin DP, Barros MP, Otton RAstaxanthin prevents in vitro auto-oxidative injury in human lymphocytesCell Biol Toxicol.(2010 Oct)
 - Pompéia C, Lopes LR, Miyasaka CK, Procópio J, Sannomiya P, Curi REffect of fatty acids on leukocyte functionBraz J Med Biol Res.(2000 Nov)