⚫️ Наукові дослідження та матеріали:
📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали:
👇 Компонент №1 - Glucosamine (глюкозамін) 🌿:
😊🩺🦴🏃♀️ Загальний вплив на здоров'я опорно-рухового апарату, кістки, хрящі, суглоби, артрит, остеоартрит, болі в поясниці, хвороба Кишина-Бека, реабілітація після травм, переломи, діапазон рухів, ефективність поєднання з хондроїтином - 45 досліджень [1-45]:
- Williams C, Ampat GGlucosamine SulfateStatPearls.(2023-01)
- Momomura R, Naito K, Igarashi M, Watari T, Terakado A, Oike S, Sakamoto K, Nagaoka I, Kaneko KEvaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racersMol Med Report.(2013 Jan 25)
- Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco JGlucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparatorArthritis Rheum.(2007 Feb)
- Dahmer S, Schiller RMGlucosamine.Am Fam Physician.(2008-Aug-15)
- Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJGlucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisN Engl J Med.(2006 Feb 23)
- Zhu X, Sang L, Wu D, Rong J, Jiang LEffectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials.J Orthop Surg Res.(2018-Jul-06)
- Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka IEvaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer playersInt I Mol Med.(2009 Oct)
- Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer MNonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients.Arch Phys Med Rehabil.(2011-Aug)
- Derwich M, Górski B, Amm E, Pawłowska EOral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review.Int J Mol Sci.(2023-Mar-03)
- Vo NX, Le NNH, Chu TDP, Pham HL, Dinh KXA, Che UTT, Ngo TTT, Bui TTEffectiveness and Safety of Glucosamine in Osteoarthritis: A Systematic Review.Pharmacy (Basel).(2023-Jul-14)
- Knudsen JF, Sokol GHPotential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database.Pharmacotherapy.(2008-Apr)
- Baron AD, Zhu JS, Zhu JH, Weldon H, Maianu L, Garvey WTGlucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.J Clin Invest.(1995-Dec)
- Herrero-Beaumont G, Rovati LC, Castañeda S, Alvarez-Soria MA, Largo RThe reverse glucosamine sulfate pathway: application in knee osteoarthritis.Expert Opin Pharmacother.(2007-Feb)
- Block JA, Oegema TR, Sandy JD, Plaas AThe effects of oral glucosamine on joint health: is a change in research approach needed?Osteoarthritis Cartilage.(2010-Jan)
- Vlad SC, LaValley MP, McAlindon TE, Felson DTGlucosamine for pain in osteoarthritis: why do trial results differArthritis Rheum.(2007 Jul)
- Henrotin Y, Mobasheri A, Marty MIs there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?Arthritis Res Ther.(2012-Jan-30)
- Meulyzer M, Vachon P, Beaudry F, Vinardell T, Richard H, Beauchamp G, Laverty SComparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride.Osteoarthritis Cartilage.(2008-Sep)
- Chhavi Asthana, Gregory M Peterson, Madhur D Shastri, Rahul P PatelVariation in the pharmacokinetics of glucosamine in healthy individualsRheumatology (Oxford).(2021 Mar 2)
- Heather C Gray, Patricia S Hutcheson, Raymond G SlavinIs glucosamine safe in patients with seafood allergy?J Allergy Clin Immunol.(2004 Aug)
- Liu W, Liu G, Pei F, Liu Y, Zhou Z, Li J, Shen B, Kang P, Xie Q, Ma XKashin-Beck disease in Sichuan, China: report of a pilot open therapeutic trialJ Clin Rheumatol.(2012 Jan)
- Singh S, Khajuria A, Taneja SC, Khajuria RK, Singh J, Qazi GNBoswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.Bioorg Med Chem Lett.(2007-Jul-01)
- Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJEffect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.Adv Ther.(2009-Sep)
- Zhu X, Wu D, Sang L, Wang Y, Shen Y, Zhuang X, Chu M, Jiang LComparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis.Clin Exp Rheumatol.(2018)
- Selvan T, Rajiah K, Nainar MS, Mathew EMA clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis.ScientificWorldJournal.(2012)
-Osteoarthritis Symptoms - Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan BAyurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trialRheumatology (Oxford).(2013 Jan 30)
-Osteoarthritis Symptoms - Vlad SC, LaValley MP, McAlindon TE, Felson DTGlucosamine for pain in osteoarthritis: why do trial results differArthritis Rheum.(2007 Jul)
-Osteoarthritis Symptoms - Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JYStructural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysisArch Intern Med.(2003 Jul 14)
-Osteoarthritis Symptoms - Yongsak Wangroongsub, Aree Tanavalee, Vajara Wilairatana, Srihatach NgarmukosComparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind studyJ Med Assoc Thai.(2010 Jul)
-Osteoarthritis Symptoms - Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJGlucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisN Engl J Med.(2006 Feb 23)
-Osteoarthritis Symptoms - Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, Reichenbach S, Trelle SEffects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysisBMJ.(2010 Sep 16)
-Osteoarthritis Symptoms - Houpt JB, McMillan R, Wein C, Paget-Dellio SDEffect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the kneeJ Rheumatol.(1999 Nov)
-Osteoarthritis Symptoms - Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MCGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2001)
-Osteoarthritis Symptoms - McAlindon TE, LaValley MP, Gulin JP, Felson DTGlucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysisJAMA.(2000 Mar 15)
-Osteoarthritis Symptoms - Pujalte JM, Llavore EP, Ylescupidez FRDouble-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosisCurr Med Res Opin.(1980)
-Osteoarthritis Symptoms - McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara KEffectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trialAm J Med.(2004 Nov 1)
-Osteoarthritis Symptoms - Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett CLong-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialLancet.(2001 Jan 27)
-Osteoarthritis Symptoms - Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco JGlucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparatorArthritis Rheum.(2007 Feb)
-Osteoarthritis Symptoms - Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LCGlucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind studyArch Intern Med.(2002 Oct 14)
-Osteoarthritis Symptoms - Hughes R, Carr AA randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the kneeRheumatology (Oxford).(2002 Mar)
-Osteoarthritis Symptoms - Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola GRandomized, controlled trial of glucosamine for treating osteoarthritis of the kneeWest J Med.(2000 Feb)
-Osteoarthritis Symptoms - Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells GGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2005 Apr 18)
-Pain - Noack W, Fischer M, Förster KK, Rovati LC, Setnikar IGlucosamine sulfate in osteoarthritis of the kneeOsteoarthritis Cartilage.(1994 Mar)
-Temporomandibular Disorders (TMD) Symptoms - Thie NM, Prasad NG, Major PWEvaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trialJ Rheumatol.(2001 Jun)
-Temporomandibular Disorders (TMD) Symptoms - Cahlin BJ, Dahlström LNo effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term studyOral Surg Oral Med Oral Pathol Oral Radiol Endod.(2011 Dec)
-Lower Back Pain - Wilkens P, Scheel IB, Grundnes O, Hellum C
👇 Компонент №2 - Chondroitin (хондроїтин) 🌿:
😊🩺🦴🏃♀️ Загальний вплив на здоров'я опорно-рухового апарату, кістки, хрящі, суглоби, артрит, остеоартрит, болі в поясниці, хвороба Кишина-Бека, реабілітація після травм, переломи, діапазон рухів, ефективність поєднання з глюкозаміном - 21 дослідження [45-66]:
-Bruyère O, Honvo G, Veronese N, Arden NK, Branco J, Curtis EM, Al-Daghri NM, Herrero-Beaumont G, Martel-Pelletier J, Pelletier JP, Rannou F, Rizzoli R, Roth R, Uebelhart D, Cooper C, Reginster JYAn updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).Semin Arthritis Rheum.(2019-Dec)
-Westmoreland CA, Koke JR, Bittar NAMP stimulation of endocytotic transport from canine coronary circulation into myocytes.Cytobios.(1986)
-Pal D, Saha SChondroitin: a natural biomarker with immense biomedical applications.RSC Adv.(2019-Sep-03)
-Hochberg MCStructure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.Osteoarthritis Cartilage.(2010-Jun)
-Zhu X, Sang L, Wu D, Rong J, Jiang LEffectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials.J Orthop Surg Res.(2018-Jul-06)
-Articles of the Hungarian Medical Journal from November, 1991.Orv Hetil.(1991-Nov-03)
-Ewald CYDrug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.Front Aging.(2021)
-Navarro SL, White E, Kantor ED, Zhang Y, Rho J, Song X, Milne GL, Lampe PD, Lampe JWRandomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.PLoS One.(2015)
-Liu B, Yang W, Zhang KRole of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.Nutr Cancer.(2023)
-Damiano R, Cicione AThe role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease.Ther Adv Urol.(2011-Oct)
-Zhang W, Deng X, Liu C, Wang XIntravesical treatment for interstitial cystitis/painful bladder syndrome: a network meta-analysis.Int Urogynecol J.(2017-Apr)
-Khan AA, Mannan V, Pervaiz MA, Akram A, Momin ES, Sanusi M, Kashyap T, Elshaikh AOThe Role of Glucosamine and Chondroitin Sulfate in the Prevention of Colorectal Cancer: A Systematic Review.Cureus.(2022-May)
-Dana E King, Jun XiangGlucosamine/Chondroitin and Mortality in a US NHANES CohortJ Am Board Fam Med.(Nov-Dec 2020)
-Hathcock JN, Shao ARisk assessment for glucosamine and chondroitin sulfate.Regul Toxicol Pharmacol.(2007-Feb)
-Brito R, Costa D, Dias C, Cruz P, Barros PChondroitin Sulfate Supplements for Osteoarthritis: A Critical Review.Cureus.(2023-Jun)
-Schiraldi C, Cimini D, De Rosa MProduction of chondroitin sulfate and chondroitin.Applied Microbiol Biotechnol.(2010-Jul)
-da Cunha AL, de Oliveira LG, Maia LF, de Oliveira LF, Michelacci YM, de Aguiar JAPharmaceutical grade chondroitin sulfate: Structural analysis and identification of contaminants in different commercial preparations.Carbohydr Polym.(2015-Dec-10)
-Osteoarthritis Symptoms - Lee YH, Woo JH, Choi SJ, Ji JD, Song GGEffect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis.Rheumatol Int.(2010-Jan)
-Osteoarthritis Symptoms - Hochberg MCStructure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.Osteoarthritis Cartilage.(2010-Jun)
-Osteoarthritis Symptoms - Honvo G, Bruyère O, Geerinck A, Veronese N, Reginster JYEfficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.Adv Ther.(2019-May)
-Osteoarthritis Symptoms - Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J HunterDietary supplements for treating osteoarthritis: a systematic review and meta-analysisBr J Sports Med.(2018 Feb)