Активатор харчових добавок (БАДів) та Регулятор рівня цукру в крові v2.0+ - на 3 супермісяці

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.1):

👇 Компонент №1 - Сurcuma longa extract (екстракт турмеріка, куркуміну) 🌿:

🥗🤩 Схуднення, зменшення ваги, жироспалювання, зайва вага, контроль апетиту, жировий (ліпідний) обмін - 39 досліджень [1-39]:
-­­ Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo MInsulin resistance associated to obesity: the link TNF-alphaArch Physiol Biochem.(2008 Jul)
-­­ The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.()
-­­ Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg ASTumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMPDiabetes.(2002 Oct)
-­­ Patton JS, Shepard HM, Wilking H, Lewis G, Aggarwal BB, Eessalu TE, Gavin LA, Grunfeld CInterferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cellsProc Natl Acad Sci U S A.(1986 Nov)
-­­ Aggarwal BBTargeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticalsAnnu Rev Nutr.(2010 Aug 21)
-­­ Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HFTumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatoryDiabetes.(2002 May)
-­­ Qiao L, Shao JSIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complexJ Biol Chem.(2006 Dec 29)
-­­ Subauste AR, Burant CFRole of FoxO1 in FFA-induced oxidative stress in adipocytesAm J Physiol Endocrinol Metab.(2007 Jul)
-­­ Ciardi C, Jenny M, Tschoner A, Ueberall F, Patsch J, Pedrini M, Ebenbichler C, Fuchs DFood additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitroBr J Nutr.(2012 Mar)
-­­ Pongchaidecha A, Lailerd N, Boonprasert W, Chattipakorn NEffects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese ratsNutrition.(2009 Jul-Aug)
-­­ Ejaz A, Wu D, Kwan P, Meydani MCurcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL miceJ Nutr.(2009 May)
-­­ Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HRCurcumin is an in vivo inhibitor of angiogenesisMol Med.(1998 Jun)
- Osteoarthritis Symptoms - Vilai Kuptniratsaikul, Sunee Thanakhumtorn, Pornsiri Chinswangwatanakul, Luksamee Wattanamongkonsil, Visanu ThamlikitkulEfficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis - J Altern Complement Med.(2009 Aug)
- Osteoarthritis Symptoms - Henrotin et alBio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study - Arthritis Res Ther.()
- Uric Acid - Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar ACurcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial - J Cardiovasc Pharmacol.(2016 Sep)
- Blood glucose - Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi CEffects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial - Eur J Nutr.(2019 Feb 22)
- Blood glucose - Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, Hosseinzadeh-Attar MJNano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial - Nutr Metab (Lond).(2019 Jan 28)
- Blood glucose - Saeede Saadati, Behzad Hatami, Zahra Yari, Mohammad Amin Shahrbaf, Sareh Eghtesad, Asieh Mansour, Hossein Poustchi, Mehdi Hedayati, Morteza Aghajanpoor-Pasha, Amir Sadeghi, Azita Hekmatdoost - The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease - Eur J Clin Nutr.(2019 Mar)
- Blood glucose - Navekar R, Rafraf M, Ghaffari A, Asghari-Jafarabadi M, Khoshbaten MTurmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases - J Am Coll Nutr.(2017 May-Jun)
- Low-density lipoprotein (LDL) - Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar ATreatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial - Phytother Res.(2016 Sep)
- Liver Enzymes - M H Ngu, M N Norhayati, Z Rosnani, M M ZulkifliCurcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysis - Complement Ther Med.(2022 Sep)
- Weight - Nima Baziar, Mohammad ParohanThe effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res.(2020 Mar)
- Weight - Jafarirad S, Mansoori A, Adineh A, Panahi Y, Hadi A, Goodarzi RDoes Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non-alcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis of Randomized Controlled Trials - Clin Nutr Res.(2019-Jul)
- Insulin - Kocher A, Bohnert L, Schiborr C, Frank JHighly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals - Mol Nutr Food Res.(2016 Jul)
- Insulin - Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha REfficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian - J Clin Biochem.(2015 Apr)
- Total cholesterol - Ferguson JJA, Wolska A, Remaley AT, Stojanovski E, MacDonald-Wicks L, Garg MLBread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trial - Food Funct.(2019 May 22)
- Total cholesterol - Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MRThe Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial - Iran J Pharm Res.(2015 Spring)
- Total cholesterol - Dehzad MJ, Ghalandari H, Amini MR, Askarpour MEffects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials - Complement Ther Med.(2023-Aug)
- Uric Acid - Pannipa Bupparenoo, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Paijit Asavatanabodee, Sumapa ChaiamnuayEffect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled Trial - J Diet Suppl.(2021)
- Blood glucose - Adab Z, Eghtesadi S, Vafa MR, Heydari I, Shojaii A, Haqqani H, Arablou T, Eghtesadi MEffect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients - Phytother Res.(2019 Apr)
- Blood glucose - Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto THighly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD - Int J Chron Obstruct Pulmon Dis.(2016 Aug 26)
- Blood glucose - Ferguson JJA, Stojanovski E, MacDonald-Wicks L, Garg MLCurcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial - Metabolism.(2018 May)
- Triglycerides - Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Ž, Majeed M, Sahebkar ACurcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial - Complement Ther Med.(2017 Aug)
- Triglycerides - DiSilvestro RA, Joseph E, Zhao S, Bomser JDiverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people - Nutr J.(2012 Sep 26)
- Triglycerides - Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M, Ferns GAEffects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial - Phytother Res.(2013 Mar)
- Low-density lipoprotein (LDL) - Baum L, Cheung SK, Mok VC, Lam LC, Leung VP, Hui E, Ng CC, Chow M, Ho PC, Lam S, Woo J, Chiu HF, Goggins W, Zee B, Wong A, Mok H, Cheng WK, Fong C, Lee JS, Chan MH, Szeto SS, Lui VW, Tsoh J, Kwok TC, Chan IH, Lam CWCurcumin effects on blood lipid profile in a 6-month human study - Pharmacol Res.(2007 Dec)
- Blood glucose - Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Ghayour Mobarhan M, Kazemi Oskuee RThe effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial - Avicenna J Phytomed.(2016 Sep-Oct)
- Blood glucose - Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, Sahebkar AEffects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial - Drug Res (Stuttg).(2018 Jul)
- Blood glucose - Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu ZCurcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies - Exp Clin Endocrinol Diabetes.(2015 Jun)

🩸🍬Регулювання глюкози (цукру) в крові, цукровий діабет, предіабет, інсулінорезистентність, профілактика діабету, холестерин - 31 дослідження [39-70]
- Blood glucose - Thota RN, Dias CB, Abbott KA, Acharya SH, Garg MLCurcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study - Sci Rep.(2018 Sep 12)
- Blood glucose - Wickenberg J, Ingemansson SL, Hlebowicz JEffects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects - Nutr J.(2010 Oct 12)
- Triglycerides - Kanit Pungcharoenkul, Phensri ThongnopnuaEffect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects - Phytother Res.(2011 Nov)
- Arterial Stiffness - Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DRCurcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress - Aging (Albany NY).(2017 Jan 3)
- Prostate Specific Antigen - Ide H, Tokiwa S, Sakamaki K, Nishio K, Isotani S, Muto S, Hama T, Masuda H, Horie SCombined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen - Prostate.(2010 Jul 1)
- Iron Absorption - Siriporn Tuntipopipat, Kunchit Judprasong, Christophe Zeder, Emorn Wasantwisut, Pattanee Winichagoon, Somsri Charoenkiatkul, Richard Hurrell, Thomas WalczykChili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal - J Nutr.(2006 Dec)
- Weight - Unhapipatpong C, Polruang N, Shantavasinkul PC, Julanon N, Numthavaj P, Thakkinstian AThe effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials - Am J Clin Nutr.(2023-May)
- Triglycerides - Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda SCurcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women - Nutr Res.(2012 Oct)
- Blood Pressure - Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda SEffect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study - Am J Hypertens.(2012 Jun)
- Triglycerides - Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra NEffect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study - Drugs R D.(2008)
– Kim T, Davis J, Zhang AJ, He X, Mathews STCurcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cellsBiochem Biophys Res Commun.(2009 Oct 16)
– Hardie DG, Hawley SAAMP-activated protein kinase: the energy charge hypothesis revisitedBioessays.(2001 Dec)
– Ikonomov OC, Sbrissa D, Mlak K, Shisheva ARequirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effectsEndocrinology.(2002 Dec)
– Yang X, Thomas DP, Zhang X, Culver BW, Alexander BM, Murdoch WJ, Rao MN, Tulis DA, Ren J, Sreejayan NCurcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formationArterioscler Thromb Vasc Biol.(2006 Jan)
– Srinivasan MEffect of curcumin on blood sugar as seen in a diabetic subjectIndian J Med Sci.(1972 Apr)
– Kim JH, Park JM, Kim EK, Lee JO, Lee SK, Jung JH, You GY, Park SH, Suh PG, Kim HSCurcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cellsJ Cell Physiol.(2010 Jun)
– Kang C, Kim ESynergistic effect of curcumin and insulin on muscle cell glucose metabolismFood Chem Toxicol.(2010 Aug-Sep)
– Pan W, Yang H, Cao C, Song X, Wallin B, Kivlin R, Lu S, Hu G, Di W, Wan YAMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cellsOncol Rep.(2008 Dec)
– Weisberg SP, Leibel R, Tortoriello DVDietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesityEndocrinology.(2008 Jul)
– Yekollu SK, Thomas R, O'Sullivan BTargeting curcusomes to inflammatory dendritic cells inhibits NF-B and improves insulin resistance in obese miceDiabetes.(2011 Nov)
– Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai SCurcumin extract for prevention of type 2 diabetesDiabetes Care.(2012 Nov)
— Xie XY, Kong PR, Wu JF, Li Y, Li YXCurcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytesPhytomedicine.(2012 Dec 15)
— Soltoff SP, Hedden LRegulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cellsAm J Physiol Cell Physiol.(2008 Sep)
— Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJCurcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cellsJ Agric Food Chem.(2009 Jan 14)
— Zhao J, Sun XB, Ye F, Tian WXSuppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcuminMol Cell Biochem.(2011 May)
-­­ Deng YT, Chang TW, Lee MS, Lin JKSuppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cellsJ Agric Food Chem.(2012 Feb 1)
-­­ Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, Sun CHCurcumin improves insulin resistance in skeletal muscle of ratsNutr Metab Cardiovasc Dis.(2011 Jul)
-­­ Cheng TC, Lin CS, Hsu CC, Chen LJ, Cheng KC, Cheng JTActivation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar ratsNeurosci Lett.(2009 Nov 20)
-­­ Xavier S, Sadanandan J, George N, Paulose CSβ(2)-Adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: Antagonism by vitamin D(3) and curcuminEur J Pharmacol.(2012 Jul 15)
-­­ He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TRCurcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed miceWorld J Diabetes.(2012 May 15)
-­­ Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM, Lee MKEffect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db miceMol Nutr Food Res.(2008 Sep)

💓🩸 Серце, кровотік, судини, атеросклероз, захист судин, клітини крові, тригліцериди, холестерин - 15 досліджень [70-85]:
- Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa KThe dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats - J Clin Invest.(2008 Mar)
- Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, Aschauer S, Helson L, Wolzt MEffect of liposomal curcumin on red blood cells in vitro - Anticancer Res.(2013 Sep)
- Tang W, Pankow JS, Carr JJ, Tracy RP, Bielinski SJ, North KE, Hopkins PN, Kraja AT, Arnett DKAssociation of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart StudyBMC Cardiovasc Disord.(2007 Oct 26)
- DiSilvestro RA, Joseph E, Zhao S, Bomser JDiverse effects of a low dose supplement of lipidated curcumin in healthy middle aged peopleNutr J.(2012 Sep 26)
- Fang XD, Yang F, Zhu L, Shen YL, Wang LL, Chen YYCurcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aortaClin Exp Pharmacol Physiol.(2009 Dec)
- Majithiya JB, Balaraman RTime-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcuminJ Cardiovasc Pharmacol.(2005 Nov)
- Sompamit K, Kukongviriyapan U, Nakmareong S, Pannangpetch P, Kukongviriyapan VCurcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in miceEur J Pharmacol.(2009 Aug 15)
- El-Bassossy HM, El-Maraghy NN, El-Fayoumi HM, Watson MLHaem oxygenase-1 induction protects against tumour necrosis factor alpha impairment of endothelial-dependent relaxation in rat isolated pulmonary arteryBr J Pharmacol.(2009 Nov)
- Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation.()
- Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda SCurcumin ingestion and exercise training improve vascular endothelial function in postmenopausal womenNutr Res.(2012 Oct)
- Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, Seals DRCurcumin ameliorates arterial dysfunction and oxidative stress with agingExp Gerontol.(2013 Feb)
- Nakmareong S, Kukongviriyapan U, Pakdeechote P, Donpunha W, Kukongviriyapan V, Kongyingyoes B, Sompamit K, Phisalaphong CAntioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertensionNaunyn Schmiedebergs Arch Pharmacol.(2011 May)
- Sagiroglu T, Kanter M, Yagci MA, Sezer A, Erboga MProtective effect of curcumin on cyclosporin A-induced endothelial dysfunction, antioxidant capacity, and oxidative damageToxicol Ind Health.(2012 Aug 17)
- Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, Dehghanzadeh GROral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled studyJ Ren Nutr.(2012 Jan)
- Pungcharoenkul K, Thongnopnua PEffect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjectsPhytother Res.(2011 Nov)

😥 Стрес, напруга, невроз, тривога, депресія - 10 досліджень [85-95]:
- General Oxidation - Kalpravidh RW, Siritanaratkul N, Insain P, Charoensakdi R, Panichkul N, Hatairaktham S, Srichairatanakool S, Phisalaphong C, Rachmilewitz E, Fucharoen SImprovement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids - Clin Biochem.(2010 Mar)
- Pain - Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni SComparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen - J Pain Res.(2013)
- Triglycerides - Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie SThe effect of curcumin on lipid level in patients with acute coronary syndrome - Acta Med Indones.(2008 Oct)
- Inflammation - Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide YCurcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial - Clin Gastroenterol Hepatol.(2006 Dec)
- Stomach Ulcers - Koosirirat C, Linpisarn S, Changsom D, Chawansuntati K, Wipasa JInvestigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients - Int Immunopharmacol.(2010 Jul)
- Mucositis Symptoms - Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S JrHigh-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus - J Am Acad Dermatol.(2012 May)
- General Oxidation - Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok VSix-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease - J Clin Psychopharmacol.(2008 Feb)
- COVID-19 Severity - Hamed Valizadeh, Samaneh Abdolmohammadi-Vahid, Svetlana Danshina, Mehmet Ziya Gencer, Ali Ammari, Armin Sadeghi, Leila Roshangar, Saeed Aslani, Abdolreza Esmaeilzadeh, Mahnaz Ghaebi, Sepehr Valizadeh, Majid AhmadiNano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients - Int Immunopharmacol.(2020 Dec)
- Pain - Agarwal KA, Tripathi CD, Agarwal BB, Saluja SEfficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study - Surg Endosc.(2011 Dec)
- Intestinal Motility - Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo TEffect of dietary turmeric on breath hydrogen - Dig Dis Sci.(2009 Aug)

🧠 Мозок, пам'ять: короткострокова і довгострокова, процеси навчання, нейропротекція, BDNF, NMDA, травми голови, Альцгеймер - 15 досліджень [95-110]:
- Colorectal Cancer Risk - Robert E Carroll, Richard V Benya, Danielle Kim Turgeon, Shaiju Vareed, Malloree Neuman, Luz Rodriguez, Madhuri Kakarala, Philip M Carpenter, Christine McLaren, Frank L Meyskens Jr, Dean E BrennerPhase IIa clinical trial of curcumin for the prevention of colorectal neoplasia - Cancer Prev Res (Phila).(2011 Mar)
- Ulcerative Colitis Symptoms - Peter R Holt, Seymour Katz, Robert KirshoffCurcumin therapy in inflammatory bowel disease: a pilot study - Dig Dis Sci.(2005 Nov)
- Interleukin 6 - T Krishnareddy N, Thomas JV, Nair SS, N Mulakal J, Maliakel BP, Krishnakumar IMA Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study - Biomed Res Int.(2018 Sep 23)
- Inflammation - Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, Dehghanzadeh GROral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study - J Ren Nutr.(2012 Jan)
- General Oxidation - Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy MCurcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal - Hum Exp Toxicol.(2010 Jun)
- Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GMPhenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology - Neurobiol Aging.(2001 Nov-Dec)
- Sharma S, Zhuang Y, Ying Z, Wu A, Gomez-Pinilla FDietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma - Neuroscience.(2009 Jul 21)
- Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GMCurcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo - J Biol Chem.(2005 Feb 18)
- Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok VSix-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease - J Clin Psychopharmacol.(2008 Feb)
- Reinke AA, Gestwicki JEStructure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility - Chem Biol Drug Des.(2007 Sep)
- Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GMBeta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin - J Neurosci.(2009 Jul 15)
- Curcumin Inhibits Formation of Amyloid b Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo.
- A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model.
- Gomez-Pinilla FCollaborative effects of diet and exercise on cognitive enhancement - Nutr Health.(2011)
- Wu A, Ying Z, Gomez-Pinilla FDocosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition - Neuroscience.(2008 Aug 26)

⏳🌿 Довголіття, старіння, омолодження, подовження тривалості життя, аутофагія - 22 дослідження [110-132]:
- Lionaki E, Markaki M, Tavernarakis NAutophagy and ageing: insights from invertebrate model organismsAgeing Res Rev.(2013 Jan)
- Markaki M, Tavernarakis NThe role of autophagy in genetic pathways influencing ageingBiogerontology.(2011 Oct)
- Pallauf K, Rimbach GAutophagy, polyphenols and healthy ageingAgeing Res Rev.(2013 Jan)
- Wu JC, Lai CS, Badmaev V, Nagabhushanam K, Ho CT, Pan MHTetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cellsMol Nutr Food Res.(2011 Nov)
- Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo YEvidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathwaysMol Pharmacol.(2007 Jul)
- Li B, Takeda T, Tsuiji K, Wong TF, Tadakawa M, Kondo A, Nagase S, Yaegashi NCurcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma CellsInt J Gynecol Cancer.(2013 Mar 23)
- Kim JY, Cho TJ, Woo BH, Choi KU, Lee CH, Ryu MH, Park HRCurcumin-induced autophagy contributes to the decreased survival of oral cancer cellsArch Oral Biol.(2012 Aug)
- Liao VH, Yu CW, Chu YJ, Li WH, Hsieh YC, Wang TTCurcumin-mediated lifespan extension in Caenorhabditis elegansMech Ageing Dev.(2011 Oct)
- Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q, Liang ZCurcumin promotes differentiation of glioma-initiating cells by inducing autophagyCancer Sci.(2012 Apr)
- Zanotto-Filho A, Coradini K, Braganhol E, Schröder R, de Oliveira CM, Simões-Pires A, Battastini AM, Pohlmann AR, Guterres SS, Forcelini CM, Beck RC, Moreira JCCurcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatmentEur J Pharm Biopharm.(2012 Nov 28)
- Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo SPivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cellsCancer Res.(2004 Jun 15)
- Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.()
- Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SDCurcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson's Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of MacroautophagyJ Neuroimmune Pharmacol.(2013 Mar)
- Soh JW, Marowsky N, Nichols TJ, Rahman AM, Miah T, Sarao P, Khasawneh R, Unnikrishnan A, Heydari AR, Silver RB, Arking RCurcumin is an early-acting stage-specific inducer of extended functional longevity in DrosophilaExp Gerontol.(2013 Feb)
- Lifespan Extension by the Antioxidant Curcumin in Drosophila Melanogaster.()
- Lee KS, Lee BS, Semnani S, Avanesian A, Um CY, Jeon HJ, Seong KM, Yu K, Min KJ, Jafari MCurcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogasterRejuvenation Res.(2010 Oct)
- Kitani K, Osawa T, Yokozawa TThe effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 miceBiogerontology.(2007 Oct)
- Kitani K, Yokozawa T, Osawa TInterventions in aging and age-associated pathologies by means of nutritional approachesAnn N Y Acad Sci.(2004 Jun)
- Spindler S, Mote PL, Flegal JM, Teter BInfluence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, Pycnogenol, quercetin and taxifolin fed isocalorically to long-lived, outcrossed miceRejuvenation Res.(2013 Feb 24)
- Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DEEvaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci.(2013 Jan)
- Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains.()
- Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Healthy Adult Volunteers.

🦠🌡️ Імунітет, імуномодулятор, запалення, інфекції, віруси, окислення, антиоксидант - 18 досліджень [132-150]:
-­­ Dominiak K, McKinney J, Heilbrun LK, Sarkar FHCritical need for clinical trials: an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaBPharm Res.(2010 Jun)
-­­ Everett PC, Meyers JA, Makkinje A, Rabbi M, Lerner APreclinical assessment of curcumin as a potential therapy for B-CLLAm J Hematol.(2007 Jan)
-­­ Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJCurcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activationCarcinogenesis.(2003 Sep)
-­­ Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BBCurcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene productsCancer Res.(2007 Apr 15)
-­­ Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock RPhase II trial of curcumin in patients with advanced pancreatic cancerClin Cancer Res.(2008 Jul 15)
-­­ Ponnurangam S, Mondalek FG, Govind J, Subramaniam D, Houchen CW, Anant S, Pantazis P, Ramanujam RPUrine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assayIn Vivo.(2010 Nov-Dec)
-­­ Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BBCurcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activationMol Pharmacol.(2006 Jan)
-­­ Dileep KV, Tintu I, Sadasivan CMolecular docking studies of curcumin analogs with phospholipase A2Interdiscip Sci.(2011 Sep)
-­­ Young NA, Bruss MS, Gardner M, Willis WL, Mo X, Valiente GR, Cao Y, Liu Z, Jarjour WN, Wu LCOral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migrationPLoS One.(2014 Nov 4)
-­­ Woo HM, Kang JH, Kawada T, Yoo H, Sung MK, Yu RActive spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytesLife Sci.(2007 Feb 13)
-­­ Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF, Rafiee PVascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcuminAm J Physiol Gastrointest Liver Physiol.(2009 Aug)
-­­ Kumar A, Dhawan S, Hardegen NJ, Aggarwal BBCurcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activationBiochem Pharmacol.(1998 Mar 15)
-­­ Bank J, Song DHCurcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal MuscleJ Surg Res.(2011 Nov 19)
-­­ Avci G, Kadioglu H, Sehirli AO, Bozkurt S, Guclu O, Arslan E, Muratli SKCurcumin protects against ischemia/reperfusion injury in rat skeletal muscleJ Surg Res.(2012 Jan)
-­­ Pizzo P, Scapin C, Vitadello M, Florean C, Gorza LGrp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cellsJ Cell Mol Med.(2010 Apr)
-­­ Shinkai Y, Yamamoto C, Kaji TLead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathwayToxicol Sci.(2010 Apr)
-­­ Sevgiler Y, Karaytug S, Karayakar FAntioxidative effects of N-acetylcysteine, lipoic acid, taurine, and curcumin in the muscle of Cyprinus carpio L. exposed to cadmiumArh Hig Rada Toksikol.(2011 Mar)
- Narayanan A, Kehn-Hall K, Senina S, Hill L, Van Duyne R, Guendel I, Das R, Baer A, Bethel L, Turrell M, Hartman AL, Das B, Bailey C, Kashanchi FCurcumin Inhibits Rift Valley Fever Virus Replication in Human CellsJ Biol Chem.(2012 Jul 30)

🦴 Суглоби, артрит, артроз, остеопороз - 2 дослідження [150-152]:
-­­ Jackson JK, Higo T, Hunter WL, Burt HMThe antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritisInflamm Res.(2006 Apr)
-­­ Ramadan G, Al-Kahtani MA, El-Sayed WMAnti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritisInflammation.(2011 Aug)

🏋️💪 Спорт, тренування, м'язи, відновлення, катаболізм, анаболізм - 6 досліджень [152-158]:
-­­ Vazeille E, Slimani L, Claustre A, Magne H, Labas R, Béchet D, Taillandier D, Dardevet D, Astruc T, Attaix D, Combaret LCurcumin treatment prevents increased proteasome and apoptosome activities in rat skeletal muscle during reloading and improves subsequent recoveryJ Nutr Biochem.(2012 Mar)
-­­ Siddiqui RA, Hassan S, Harvey KA, Rasool T, Das T, Mukerji P, DeMichele SAttenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing miceBr J Nutr.(2009 Oct)
-­­ Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, Reid MBTNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscleFASEB J.(2005 Mar)
- Chaudhary A, Bhandari A, Pandurangan AAntioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) GmelinAnc Sci Life.(2012 Jan)
-­­ Koren E, Zverev I, Ginsburg I, Kohen RSupplementation with antioxidants fails to increase the total antioxidant capacity of several cell lines in cultureBiomed Pharmacother.(2008 Mar)
-­­ Voronin MV, Sidneva ES, Lisitsyna TA, Zhanataev AK, Durnev ADTotal antioxidant capacity of blood plasma from healthy donors receiving vitamin and mineral complexBull Exp Biol Med.(2004 May)

🍌 Тестостерон, чоловіча репродуктивна система, спермогенез, потенція - 8 досліджень [158-170]:
-­­ Karbalay-Doust S, Noorafshan AAmeliorative effects of curcumin on the spermatozoon tail length, count, motility and testosterone serum level in metronidazole-treated micePrague Med Rep.(2011)
-­­ Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruffoli RCurcumin protects Leydig cells of mice from damage induced by chronic alcohol administrationMed Sci Monit.(2008 Nov)
-­­ Quintans LN, Castro GD, Castro JAOxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomesArch Toxicol.(2005 Jan)
-­­ Chandra AK, Chatterjee A, Ghosh R, Sarkar MEffect of curcumin on chromium-induced oxidative damage in male reproductive systemEnviron Toxicol Pharmacol.(2007 Sep)
-­­ Aktas C, Kanter M, Erboga M, Ozturk SAnti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testesToxicol Ind Health.(2012 Mar)
-­­ Murphy CJ, Tang H, Van Kirk EA, Shen Y, Murdoch WJReproductive effects of a pegylated curcuminReprod Toxicol.(2012 Aug)
-­­ White EL, Ross LJ, Steele VE, Kelloff GJ, Hill DLScreening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assayAnticancer Res.(1999 Mar-Apr)
-­­ Valentine SP, Le Nedelec MJ, Menzies AR, Scandlyn MJ, Goodin MG, Rosengren RJCurcumin modulates drug metabolizing enzymes in the female Swiss Webster mouseLife Sci.(2006 Apr 11)

🚺🌸 Жіноче здоров'я, жіночі гормони, естроген - 5 досліджень [170-175]:
-­­ White EL, Ross LJ, Steele VE, Kelloff GJ, Hill DLScreening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assayAnticancer Res.(1999 Mar-Apr)
-­­ Valentine SP, Le Nedelec MJ, Menzies AR, Scandlyn MJ, Goodin MG, Rosengren RJCurcumin modulates drug metabolizing enzymes in the female Swiss Webster mouseLife Sci.(2006 Apr 11)
-­­ Folwarczna J, Zych M, Trzeciak HIEffects of curcumin on the skeletal system in ratsPharmacol Rep.(2010 Sep-Oct)
-­­ Bachmeier BE, Mirisola V, Romeo F, Generoso L, Esposito A, Dell'eva R, Blengio F, Killian PH, Albini A, Pfeffer UReference profile correlation reveals estrogen-like trancriptional activity of CurcuminCell Physiol Biochem.(2010)
-­­ Singh M, Singh NCurcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cellsMol Cell Biochem.(2011 Jan)

🙌 Зменшення болю, анальгетик - 4 дослідження [175-179]:
- Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni SComparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen - J Pain Res.(2013)
- Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GProduct-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis - Panminerva Med.(2010 Jun)
- Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GEfficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients - Altern Med Rev.(2010 Dec)
- Agarwal KA, Tripathi CD, Agarwal BB, Saluja SEfficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study - Surg Endosc.(2011 Dec)

🌱➕🌶️ Поєднання екстракту турмерік (куркумін) + піперин (екстракт чорного перцю) + капсаїціин (екстракт каєнського перцю) - 10 досліджень [179-189]:
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PSInfluence of piperine on the pharmacokinetics of curcumin in animals and human volunteersPlanta Med.(1998 May)
- Sehgal A, Kumar M, Jain M, Dhawan DKSynergistic effects of piperine and curcumin in modulating benzo(a)pyrene induced redox imbalance in mice lungsToxicol Mech Methods.(2012 Jan)
- Sehgal A, Kumar M, Jain M, Dhawan DPiperine as an adjuvant increases the efficacy of curcumin in mitigating benzo(a)pyrene toxicityHum Exp Toxicol.(2012 May)
- Sehgal A, Kumar M, Jain M, Dhawan DKCombined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damageFood Chem Toxicol.(2011 Nov)
- Hlavačková L, Janegová A, Uličná O, Janega P, Cerná A, Babál PSpice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertensionNutr Metab (Lond).(2011 Oct 17)
-­­ Kinoshita A, Wanibuchi H, Morimura K, Wei M, Nakae D, Arai T, Minowa O, Noda T, Nishimura S, Fukushima SCarcinogenicity of dimethylarsinic acid in Ogg1-deficient miceCancer Sci.(2007 Jun)
-­­ Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy MCurcumin protects DNA damage in a chronically arsenic-exposed population of West BengalHum Exp Toxicol.(2010 Jun)
-­­ Mukundan MA, Chacko MC, Annapurna VV, Krishnaswamy KEffect of turmeric and curcumin on BP-DNA adductsCarcinogenesis.(1993 Mar)
-­­ Sharma RA, Ireson CR, Verschoyle RD, Hill KA, Williams ML, Leuratti C, Manson MM, Marnett LJ, Steward WP, Gescher AEffects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levelsClin Cancer Res.(2001 May)
- Murakami A, Furukawa I, Miyamoto S, Tanaka T, Ohigashi HCurcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesisBiofactors.(2013 Mar-Apr)

🌱➕🐟 Поєднання екстракту турмерік (куркумін) + омега 3, риб'ячий жир, ДГК - 8 досліджень [189-197]:
- Altenburg JD, Bieberich AA, Terry C, Harvey KA, Vanhorn JF, Xu Z, Jo Davisson V, Siddiqui RAA synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound aloneBMC Cancer.(2011 Apr 21)
- Saw CL, Huang Y, Kong ANSynergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acidBiochem Pharmacol.(2010 Feb 1)
- Erections - Choi YH, Han DH, Kim SW, Kim MJ, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HYA randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation - Prostate.(2019 May)
- Inflammation - Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh GOral supplementation of turmeric attenuates proteinuria, transforming growth factor-b and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study - Scand J Urol Nephrol.(2011 Nov)
- Leg Edema - Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi GPotential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study - Panminerva Med.(2011 Sep)
- Pancreatitis Symptoms - Durgaprasad S, Pai CG, Vasanthkumar, Alvres JF, Namitha SA pilot study of the antioxidant effect of curcumin in tropical pancreatitis - Indian J Med Res.(2005 Oct)
- Fructosamine - Thota RN, Acharya SH, Garg MLCurcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial - Lipids Health Dis.(2019 Jan 26)
- Colorectal Cancer Risk - He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang JUpregulation of p53 expression in patients with colorectal cancer by administration of curcumin - Cancer Invest.(2011 Mar)

🌱➕🌿 Поєднання екстракту турмерік (куркумін) + екстракт імбиру - 2 дослідження [197-199]:
- Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, Johnson KJ, Varani JA combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skinWound Repair Regen.(2009 May-Jun)
- Madkor HR, Mansour SW, Ramadan GModulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic ratsBr J Nutr.(2011 Apr)

🦠🔴 Рак, пухлини, онкозахворювання, профілактика онкозахворювань - 9 дослідження [199-208]:
-­­ Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbaum CS, Das T, Sa GTumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcuminCancer Res.(2007 Jan 1)
-­­ Deeb D, Jiang H, Gao X, Hafner MS, Wong H, Divine G, Chapman RA, Dulchavsky SA, Gautam SCCurcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylationMol Cancer Ther.(2004 Jul)
-­­ Deeb D, Jiang H, Gao X, Al-Holou S, Danyluk AL, Dulchavsky SA, Gautam SCCurcumin {1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6} sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathwayJ Pharmacol Exp Ther.(2007 May)
-­­ Song WB, Wang YY, Meng FS, Zhang QH, Zeng JY, Xiao LP, Yu XP, Peng DD, Su L, Xiao B, Zhang ZSCurcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activationPLoS One.(2010 Sep 24)
-­­ Kim YS, Ahn Y, Hong MH, Joo SY, Kim KH, Sohn IS, Park HW, Hong YJ, Kim JH, Kim W, Jeong MH, Cho JG, Park JC, Kang JCCurcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cellsJ Cardiovasc Pharmacol.(2007 Jul)
-­­ Camacho-Barquero L, Villegas I, Sánchez-Calvo JM, Talero E, Sánchez-Fidalgo S, Motilva V, Alarcón de la Lastra CCurcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitisInt Immunopharmacol.(2007 Mar)
-­­ Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2.()
-­­ Chintharlapalli S1, Papineni S, Ramaiah SK, Safe SBetulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factorsCancer Res.(2007 Mar 15)
-­­ Chadalapaka G1, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe SCurcumin decreases specificity protein expression in bladder cancer cellsCancer Res.(2008 Jul 1)

🌾 Кишечник, кишківний тракт - 9 дослідження [208-210]:
- Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide YCurcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trialClin Gastroenterol Hepatol.(2006 Dec)
- Holt PR, Katz S, Kirshoff RCurcumin therapy in inflammatory bowel disease: a pilot studyDig Dis Sci.(2005 Nov)

🍔 Печінка - 7 досліджень [208-215]:
- Um MY, Hwang KH, Ahn J, Ha TYCurcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMPKBasic Clin Pharmacol Toxicol.(2013 Apr 9)

🚰 Нирки - 5 досліджень [215-220]
- Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh GOral supplementation of turmeric attenuates proteinuria, transforming growth factor-b and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled studyScand J Urol Nephrol.(2011 Nov)
- Zhong F, Chen H, Han L, Jin Y, Wang WCurcumin attenuates lipopolysaccharide-induced renal inflammationBiol Pharm Bull.(2011)
- Ghosh SS, Massey HD, Krieg R, Fazelbhoy ZA, Ghosh S, Sica DA, Fakhry I, Gehr TWCurcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammationAm J Physiol Renal Physiol.(2009 May)
- Hill-Kapturczak N, Thamilselvan V, Liu F, Nick HS, Agarwal AMechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cellsAm J Physiol Renal Physiol.(2001 Nov)
- Gaedeke J, Noble NA, Border WACurcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1Kidney Int.(2005 Nov)


👇 Компонент №2 - Syzygium aromaticum extract (екстракт сизигію ароматного, гвоздики) 🌿:

🍌 Ерекція, потенція, лібідо, сексуальна (інтимна) сила, афродизіак, потенція, фертильність, тестостерон, сексуальність, спермогенез - 6 досліджень [215-221]:
- Domaracký M, Rehák P, Juhás S, Koppel JEffects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivoPhysiol Res.(2007)
- Mishra RK, Singh SKSafety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in miceFood Chem Toxicol.(2008 Oct)
- Tajuddin, Ahmad S, Latif A, Qasmi IAAphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative studyBMC Complement Altern Med.(2003 Oct 20)
- Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats.()
- Buch JG, Dikshit RK, Mansuri SMEffect of certain volatile oils on ejaculated human spermatozoaIndian J Med Res.(1988 Apr)
- Vanithakumari G, Sampathraj R, Selvaraj M, Thangamani REffect of short-term treatment of eugenol on the seminal vesicles of adult albino ratsIndian J Exp Biol.(1998 Dec)

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.2):

👇 Компонент №3 - Allium sativum (екстракт часнику) 🌿:

🥗🤩 Схуднення, зайва вага, ожиріння - 6 досліджень [221-247]:
- Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, Mounier R, Andreelli F, Foretz MAMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectivesActa Physiol (Oxf) (2009 May)
- Lane MD, Wolfgang M, Cha SH, Dai YRegulation of food intake and energy expenditure by hypothalamic malonyl-CoAInt J Obes (Lond) (2008 Sep)
- Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria.
- Garlic supplementation enhances norepinephrine secretion, growth of brown adipose tissue, and triglyceride catabolism in rats.
- Oi Y, Kawada T, Shishido C, Wada K, Kominato Y, Nishimura S, Ariga T, Iwai KAllyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in ratsJ Nutr (1999 Feb)
- Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria.
- Flaim KE, Horwitz BA, Horowitz JMCoupling of signals to brown fat: alpha- and beta-adrenergic responses in intact ratsAm J Physiol (1977 Mar)
- Rothwell NJ, Stock MJInfluence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesisPflugers Arch (1981 Mar)
- Bukowiecki L, Jahjah L, Follea NEphedrine, a potential slimming drug, directly stimulates thermogenesis in brown adipocytes via beta-adrenoreceptorsInt J Obes (1982)
- Carey AL, Formosa MF, Van Every B, Bertovic D, Eikelis N, Lambert GW, Kalff V, Duffy SJ, Cherk MH, Kingwell BAEphedrine activates brown adipose tissue in lean but not obese humansDiabetologia (2013 Jan)
- Wolf GBrown adipose tissue: the molecular mechanism of its formationNutr Rev (2009 Mar)
- Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LACloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesisDiabetes (1997 May)
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💥 Енергія, оптимізм, настрій, позитив, норадреналін, впевненість, рішучість - 11 досліджень [247-258]:
- Garlic supplementation enhances norepinephrine secretion, growth of brown adipose tissue, and triglyceride catabolism in rats.
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- Wolf GBrown adipose tissue: the molecular mechanism of its formationNutr Rev (2009 Mar)
- Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LACloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesisDiabetes (1997 May)
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- Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BBAdrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivoJ Biol Chem (2011 Mar 18)

🧠 Мозок, пам'ять, процеси навчання, когнітивні функції - 5 досліджень [258-263]:
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-Devrim E, Durak IIs garlic a promising food for benign prostatic hyperplasia and prostate cancerMol Nutr Food Res.(2007 Nov)
-Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer.()

❤️ Серцево-судинне здоров'я: серце, судини, артерії, вени, розрідження крові, кровотік, атеросклероз, варикоз, тромбоз, ліпіди, міокард, антикоагулянт - 15 досліджень [263-278]:
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💔🩹 Судини, артерії, вени: атеросклероз, холестерин, розширення судин, артеріальний тиск, тромбоз - 65 досліджень [278-358]:
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🩸🍬 Регуляція цукру в крові, глюкоза, цукровий діабет, предіабет, профілактика діабету, підшлункова залоза - 25 досліджень [358-383]:
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🦠🔴 Імунітет, захворювання, інфекції, віруси, інтерферони, імуноглобуліни, клетки-кілери, Т-клітини - 69 досліджень [383-452]:
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- Dal-Secco D, Cunha TM, Freitas A, Alves-Filho JC, Souto FO, Fukada SY, Grespan R, Alencar NM, Neto AF, Rossi MA, Ferreira SH, Hothersall JS, Cunha FQHydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channelsJ Immunol.(2008 Sep 15)
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- Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA, Ma AMacrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsetsImmunity.(2009 Nov 20)
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-Kasuga S, Uda N, Kyo E, Ushijima M, Morihara N, Itakura YPharmacologic activities of aged garlic extract in comparison with other garlic preparationsJ Nutr.(2001 Mar)
-Kyo E, Uda N, Ushijima M, Kasuga S, Itakura YPrevention of psychological stress-induced immune suppression by aged garlic extractPhytomedicine.(1999 Nov)
-Liu ZX, Govindarajan S, Kaplowitz NInnate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicityGastroenterology.(2004 Dec)
-Ishida Y, Kondo T, Ohshima T, Fujiwara H, Iwakura Y, Mukaida NA pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injuryFASEB J.(2002 Aug)
-Kim YR, Lee NJ, Ban JO, Yoo HS, Lee YM, Yoon YP, Eum SY, Jeong HS, Yoon DY, Han SB, Hong JTCurative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer CellsEvid Based Complement Alternat Med.(2013)
-Hedges JF, Lubick KJ, Jutila MAGamma delta T cells respond directly to pathogen-associated molecular patternsJ Immunol.(2005 May 15)
-Jutila MA, Holderness J, Graff JC, Hedges JFAntigen-independent priming: a transitional response of bovine gammadelta T-cells to infectionAnim Health Res Rev.(2008 Jun)
-Morita CT, Mariuzza RA, Brenner MBAntigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune systemSpringer Semin Immunopathol.(2000)
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-Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea: Implications for Innate Immunity.()
-Graff JC, Jutila MADifferential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenolsJ Leukoc Biol.(2007 Sep)
-Mirabeau TY, Samson ESEffect of allium cepa and allium sativum on some immunological cells in ratsAfr J Tradit Complement Altern Med.(2012 Apr 2)
-Geng Z, Rong Y, Lau BHS-allyl cysteine inhibits activation of nuclear factor kappa B in human T cellsFree Radic Biol Med.(1997)
-Heikkinen T, Järvinen AThe common coldLancet.(2003 Jan 4)
-Lissiman E, Bhasale AL, Cohen MGarlic for the common coldCochrane Database Syst Rev.(2012 Mar 14)
-Josling PPreventing the common cold with a garlic supplement: a double-blind, placebo-controlled surveyAdv Ther.(2001 Jul-Aug)
-Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold.()
-Epidemiological Investigation for Common Cold Preventive Effect of KYOLEOPIN and LEOPIN FIVE.()
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-Andrianova IV, Sobenin IA, Sereda EV, Borodina LI, Studenikin MIEffect of long-acting garlic tablets "allicor" on the incidence of acute respiratory viral infections in childrenTer Arkh.(2003)
-Abel-Salam BKImmunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino ratAllergol Immunopathol (Madr).(2012 Nov-Dec)
-Liu C, Wang C, Robison E, Levine AM, Gandhi M, Schwartz R, Weber KM, Merenstein DShort-term garlic supplementation and highly active antiretroviral treatment adherence, CD4+ cell counts, and human immunodeficiency virus viral loadAltern Ther Health Med.(2012 Jan-Feb)
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-Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB.()
-Dirsch VM, Antlsperger DS, Hentze H, Vollmar AMAjoene, an experimental anti-leukemic drug: mechanism of cell deathLeukemia.(2002 Jan)
-Li M, Ciu JR, Ye Y, Min JM, Zhang LH, Wang K, Gares M, Cros J, Wright M, Leung-Tack JAntitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction propertiesCarcinogenesis.(2002 Apr)
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-Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, Liu WD, Hu Y, Han ZX, Crystal-Mansour S, Pee D, Blot WJ, Fraumeni JF Jr, You WC, Gail MHFifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortalityJ Natl Cancer Inst.(2012 Mar 21)
-Balasenthil S, Rao KS, Nagini SApoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz{a}anthracene-induced hamster buccal pouch carcinogenesisCell Biochem Funct.(2002 Sep)
-Balasenthil S, Ramachandran CR, Nagini SS-allylcysteine, a garlic constituent, inhibits 7,12-dimethylbenz{a}anthracene-induced hamster buccal pouch carcinogenesisNutr Cancer.(2001)
-Balasenthil S, Rao KS, Nagini SGarlic induces apoptosis during 7,12-dimethylbenz{a}anthracene-induced hamster buccal pouch carcinogenesisOral Oncol.(2002 Jul)
-Velmurugan B, Mani A, Nagini SCombination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesisEur J Cancer Prev.(2005 Aug)
-Velmurugan B, Nagini SCombination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidantsJ Med Food.(2005 Winter)
-Lee Y, Kim H, Lee J, Kim KAnticancer activity of S-allylmercapto-L-cysteine on implanted tumor of human gastric cancer cellBiol Pharm Bull.(2011)
-Ebrahimpour S, Tabari MA, Youssefi MR, Aghajanzadeh H, Behzadi MYSynergistic effect of aged garlic extract and naltrexone on improving immune responses to experimentally induced fibrosarcoma tumor in BALB/c micePharmacognosy Res.(2013 Jul)
-Fallah-Rostami F, Tabari MA, Esfandiari B, Aghajanzadeh H, Behzadi MYImmunomodulatory activity of aged garlic extract against implanted fibrosarcoma tumor in miceN Am J Med Sci.(2013 Mar)

🔴🍌 Рак передміхурової залози - 18 досліджень [452-470]:
-Zhou XF, Ding ZS, Liu NBAllium vegetables and risk of prostate cancer: evidence from 132,192 subjectsAsian Pac J Cancer Prev.(2013)
-Hardin J, Cheng I, Witte JSImpact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer riskNutr Cancer.(2011)
-Salem S, Salahi M, Mohseni M, Ahmadi H, Mehrsai A, Jahani Y, Pourmand GMajor dietary factors and prostate cancer risk: a prospective multicenter case-control studyNutr Cancer.(2011)
-Brasky TM, Kristal AR, Navarro SL, Lampe JW, Peters U, Patterson RE, White ESpecialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohortNutr Cancer.(2011)
-Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF JrAllium vegetables and risk of prostate cancer: a population-based studyJ Natl Cancer Inst.(2002 Nov 6)
-Galeone C, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, Giacosa A, La Vecchia COnion and garlic use and human cancerAm J Clin Nutr.(2006 Nov)
-Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer.()
-Mazdak H, Mazdak M, Jamali L, Keshteli AHDetermination of prostate cancer risk factors in Isfahan, Iran: a case-control studyMed Arh.(2012)
-Sielicka-Dudzin A, Borkowska A, Herman-Antosiewicz A, Wozniak M, Jozwik A, Fedeli D, Antosiewicz JImpact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfideEur J Nutr.(2012 Aug)
-Borkowska A, Knap N, Antosiewicz JDiallyl Trisulfide Is More Cytotoxic to Prostate Cancer Cells PC-3 than to Noncancerous Epithelial Cell Line PNT1A: A Possible Role of p66Shc signaling AxisNutr Cancer.(2013 Jul)
-Antosiewicz J, Herman-Antosiewicz A, Marynowski SW, Singh SVc-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cellsCancer Res.(2006 May 15)
-Borkowska A, Sielicka-Dudzin A, Herman-Antosiewicz A, Halon M, Wozniak M, Antosiewicz JP66Shc mediated ferritin degradation--a novel mechanism of ROS formationFree Radic Biol Med.(2011 Aug 1)
-Borkowska A, Sielicka-Dudzin A, Herman-Antosiewicz A, Wozniak M, Fedeli D, Falcioni G, Antosiewicz JDiallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shcEur J Nutr.(2012 Oct)
-Tsuji Y, Moran E, Torti SV, Torti FMTranscriptional regulation of the mouse ferritin H gene. Involvement of p300/CBP adaptor proteins in FER-1 enhancer activityJ Biol Chem.(1999 Mar 12)
-Kruszewski MLabile iron pool: the main determinant of cellular response to oxidative stressMutat Res.(2003 Oct 29)
-Epsztejn S, Glickstein H, Picard V, Slotki IN, Breuer W, Beaumont C, Cabantchik ZIH-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance propertiesBlood.(1999 Nov 15)
-Shin DY, Kim GY, Lee JH, Choi BT, Yoo YH, Choi YHApoptosis Induction of Human Prostate Carcinoma DU145 Cells by Diallyl Disulfide via Modulation of JNK and PI3K/AKT Signaling PathwaysInt J Mol Sci.(2012 Nov 2)
-Gayathri R, Gunadharini DN, Arunkumar A, Senthilkumar K, Krishnamoorthy G, Banudevi S, Vignesh RC, Arunakaran JEffects of diallyl disulfide (DADS) on insulin-like growth factor signaling molecules involved in cell survival

🔴🚰 Рак сечового міхура - 15 досліджень [470-485]:
-Hotaling JM, Wright JL, Pocobelli G, Bhatti P, Porter MP, White ELong-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins And Lifestyle studyJ Urol.(2011 Apr)
-Borden EC, Groveman DS, Nasu T, Reznikoff C, Bryan GTAntiproliferative activities of interferons against human bladder carcinoma cell lines in vitroJ Urol.(1984 Oct)
-Grups JW, Frohmüller HGAntiproliferative effects of interferons against human bladder carcinoma cell lines in vitroUrol Int.(1988)
-Kälble T, Beer M, Mendoza E, Ikinger U, Link M, Reichert HE, Frangenheim T, Klein E, Fabricius PGBCG vs interferon A for prevention of recurrence of superficial bladder cancer. A prospective randomized studyUrologe A.(1994 Mar)
-Joudi FN, Smith BJ, O&#039;Donnell MA; National BCG-Interferon Phase 2 Investigator GroupFinal results from a national multicenter phase II trial of combination bacillus Calmette-Guérin plus interferon alpha-2B for reducing recurrence of superficial bladder cancerUrol Oncol.(2006 Jul-Aug)
-Lamm DL, Riggs DRThe potential application of Allium sativum (garlic) for the treatment of bladder cancerUrol Clin North Am.(2000 Feb)
-Kassouf W, Kamat AMCurrent state of immunotherapy for bladder cancerExpert Rev Anticancer Ther.(2004 Dec)
-Lamm DL, Riggs DREnhanced immunocompetence by garlic: role in bladder cancer and other malignanciesJ Nutr.(2001 Mar)
-Lau BH, Woolley JL, Marsh CL, Barker GR, Koobs DH, Torrey RRSuperiority of intralesional immunotherapy with Corynebacterium parvum and Allium sativum in control of murine transitional cell carcinomaJ Urol.(1986 Sep)
-Marsh CL, Torrey RR, Woolley JL, Barker GR, Lau BHSuperiority of intravesical immunotherapy with Corynebacterium parvum and Allium sativum in control of murine bladder cancerJ Urol.(1987 Feb)
-Chung JGEffects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in human bladder tumor cellsDrug Chem Toxicol.(1999 May)
-Chung JG, Lu HF, Yeh CC, Cheng KC, Lin SS, Lee JHInhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfideFood Chem Toxicol.(2004 Feb)
-Lu HF, Sue CC, Yu CS, Chen SC, Chen GW, Chung JGDiallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cellsFood Chem Toxicol.(2004 Oct)
-Wang YB, Qin J, Zheng XY, Bai Y, Yang K, Xie LPDiallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cellsPhytomedicine.(2010 Apr)
-Hu H, Zhang XP, Wang YL, Chua CW, Luk SU, Wong YC, Ling MT, Wang XF, Xu KXIdentification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cellsMol Med Rep.(2011 Jan-Feb)

🔴🥦 Рак кишечник, кишківник, товста кишка - 11 досліджень [485-496]:
-Witte JS, Longnecker MP, Bird CL, Lee ER, Frankl HD, Haile RWRelation of vegetable, fruit, and grain consumption to colorectal adenomatous polypsAm J Epidemiol.(1996 Dec 1)
-Millen AE, Subar AF, Graubard BI, Peters U, Hayes RB, Weissfeld JL, Yokochi LA, Ziegler RG; PLCO Cancer Screening Trial Project TeamFruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trialAm J Clin Nutr.(2007 Dec)
-Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JDVegetables, fruit, and colon cancer in the Iowa Women&#039;s Health StudyAm J Epidemiol.(1994 Jan 1)
-Inhibition of Histone Deacetylase Activity by Butyrate.()
-Gartel AL, Tyner ALTranscriptional regulation of the p21((WAF1/CIP1)) geneExp Cell Res.(1999 Feb 1)
-Druesne-Pecollo N, Pagniez A, Thomas M, Cherbuy C, Duée PH, Martel P, Chaumontet CDiallyl disulfide increases CDKN1A promoter-associated histone acetylation in human colon tumor cell linesJ Agric Food Chem.(2006 Oct 4)
-Chen CY, Huang CF, Tseng YT, Kuo SYDiallyl disulfide induces Ca2+ mobilization in human colon cancer cell line SW480Arch Toxicol.(2012 Feb)
-Altonsy MO, Andrews SCDiallyl disulphide, a beneficial component of garlic oil, causes a redistribution of cell-cycle growth phases, induces apoptosis, and enhances butyrate-induced apoptosis in colorectal adenocarcinoma cells (HT-29)Nutr Cancer.(2011)
-Kinzler KW, Vogelstein BLessons from hereditary colorectal cancerCell.(1996 Oct 18)
-Moser AR, Pitot HC, Dove WFA dominant mutation that predisposes to multiple intestinal neoplasia in the mouseScience.(1990 Jan 19)
-Kang JS, Kim TM, Shim TJ, Salim EI, Han BS, Kim DJModifying effect of diallyl sulfide on colon carcinogenesis in C57BL/6J-ApcMin/⁺ miceAsian Pac J Cancer Prev.(2012)

🍌 Ерекція, потенція, лібідо, сексуальна (інтимна) сила, афродизіак, фертильність, тестостерон, сексуальність, передміхурова залоза, спермогенез - 20 досліджень [496-516]:
-Qian YX, Shen PJ, Xu RY, Liu GM, Yang HQ, Lu YS, Sun P, Zhang RW, Qi LM, Lu QHSpermicidal effect in vitro by the active principle of garlicContraception.(1986 Sep)
-Abdelmalik SWHistological and ultrastructural changes in the adult male albino rat testes following chronic crude garlic consumptionAnn Anat.(2011 Mar)
-Dixit VP, Joshi SEffects of chronic administration of garlic (Allium sativum Linn) on testicular functionIndian J Exp Biol.(1982 Jul)
-Protective effects of garlic (Allium sativum) extract upon lindane-induced oxidative stress and related damages in testes and brain of male rats.()
-Lee SC, Hwang SY, Kim SW, Kim SKEthanol extract of Allium sativum attenuates testicular and liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in ratsJ Med Food.(2009 Feb)
-Qiu X, Villalta J, Lin G, Lue TFRole of hydrogen sulfide in the physiology of penile erectionJ Androl.(2012 Jul-Aug)
-d'Emmanuele di Villa Bianca R, Sorrentino R, Mirone V, Cirino GHydrogen sulfide and erectile function: a novel therapeutic targetNat Rev Urol.(2011 May)
-Burnett ALNovel nitric oxide signaling mechanisms regulate the erectile responseInt J Impot Res.(2004 Jun)
-Carson CC, Lue TFPhosphodiesterase type 5 inhibitors for erectile dysfunctionBJU Int.(2005 Aug)
-d'Emmanuele di Villa Bianca R, Sorrentino R, Maffia P, Mirone V, Imbimbo C, Fusco F, De Palma R, Ignarro LJ, Cirino GHydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxationProc Natl Acad Sci U S A.(2009 Mar 17)
-Srilatha B, Adaikan PG, Li L, Moore PKHydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile functionJ Sex Med.(2007 Sep)
-Srilatha B, Adaikan PG, Moore PKPossible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot studyEur J Pharmacol.(2006 Mar 27)
-Extracts from the history and medical properties of garlic.()
-Musicki B, Burnett ALEndothelial dysfunction in diabetic erectile dysfunctionInt J Impot Res.(2007 Mar-Apr)
-Yang J, Wang T, Yang J, Rao K, Zhan Y, Chen RB, Liu Z, Li MC, Zhuan L, Zang GH, Guo SM, Xu H, Wang SG, Liu JH, Ye ZQS-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic ratsAndrology.(2013 May)
-Wagenlehner FM, Weidner W, Naber KGTherapy for prostatitis, with emphasis on bacterial prostatitisExpert Opin Pharmacother.(2007 Aug)
-Treatment of Bacterial Prostatitis.()
-Sohn DW, Han CH, Jung YS, Kim SI, Kim SW, Cho YHAnti-inflammatory and antimicrobial effects of garlic and synergistic effect between garlic and ciprofloxacin in a chronic bacterial prostatitis rat modelInt J Antimicrob Agents.(2009 Sep)
-Devrim E, Durak IIs garlic a promising food for benign prostatic hyperplasia and prostate cancerMol Nutr Food Res.(2007 Nov)
-Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer.

💪🍌 Тестостерон, сила, спорт, витривалість, гіпертрофія, м'язи, спортивні показники, чоловіче здоров'я, гормон росту - 5 досліджень [516-521]:
-Sadik NAEffects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male ratsJ Biochem Mol Toxicol.(2008 Sep-Oct)
-Oi Y, Imafuku M, Shishido C, Kominato Y, Nishimura S, Iwai KGarlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein dietJ Nutr.(2001 Aug)
-Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action.()
-Morgan JR, Barrandon Y, Green H, Mulligan RCExpression of an exogenous growth hormone gene by transplantable human epidermal cellsScience.(1987 Sep 18)
-Buz'Zard AR, Peng Q, Lau BHKyolic and Pycnogenol increase human growth hormone secretion in genetically-engineered keratinocytesGrowth Horm IGF Res.(2002 Feb)

🦴 Кістки, суглоби, біль в суглобах, артрит, хрящі, зуби - 7 досліджень [521-528]:
- Verma SK, Rajeevan V, Jain P, Bordia AEffect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery diseaseIndian J Physiol Pharmacol.(2005 Jan)
- Obalum DC, Ogo CNUsage of Complementary and Alternative Medicine (CAM) among osteoarthritis patients attending an urban multi-specialist hospital in Lagos, NigeriaNiger Postgrad Med J.(2011 Mar)
- Zochling J, March L, Lapsley H, Cross M, Tribe K, Brooks
-Williams FM, Skinner J, Spector TD, Cassidy A, Clark IM, Davidson RM, MacGregor AJDietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of actionBMC Musculoskelet Disord.(2010 Dec 8)
-Elnima EI, Ahmed SA, Mekkawi AG, Mossa JSThe antimicrobial activity of garlic and onion extractsPharmazie.(1983 Nov)
-Houshmand B, Mahjour F, Dianat OAntibacterial effect of different concentrations of garlic (Allium sativum) extract on dental plaque bacteriaIndian J Dent Res.(2013 Jan-Feb)
-Fani MM, Kohanteb J, Dayaghi MInhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Strept

🧹 Детокс, очищення організму, антиоксидант, закислення організму, окислення ліпідів, пошкодження ДНК - 5 досліджень [528-533]:
-de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, van Horssen JNrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative diseaseFree Radic Biol Med.(2008 Nov 15)
-van Muiswinkel FL, Kuiperij HBThe Nrf2-ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disordersCurr Drug Targets CNS Neurol Disord.(2005 Jun)
-Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQThe activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stressBiochim Biophys Acta.(2013 Oct)
-Zhu X, Fan WG, Li DP, Kung H, Lin MCHeme oxygenase-1 system and gastrointestinal inflammation: a short reviewWorld J Gastroenterol.(2011 Oct 14)
-Predmore BL, Kondo K, Bhushan S, Zlatopolsky MA, King AL, Aragon JP, Grinsfelder DB, Condit ME, Lefer DJThe polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailabilityAm J Physiol Heart Circ Physiol.(2012 Jun 1)

🍽️ ШКТ, шлунок - 11 досліджень [533-544]:
-Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RKHelicobacter pylori infection and the risk of gastric carcinomaN Engl J Med.(1991 Oct 17)
-Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection.()
-Lind T, Veldhuyzen van Zanten S, Unge P, Spiller R, Bayerdörffer E, O'Morain C, Bardhan KD, Bradette M, Chiba N, Wrangstadh M, Cederberg C, Idström JPEradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I StudyHelicobacter.(1996 Sep)
-Boyanova L, Ilieva J, Gergova G, Davidkov L, Spassova Z, Kamburov V, Katsarov N, Mitov INumerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian studyJ Med Microbiol.(2012 Jan)
-Antibacterial effect of garlic and omeprazole on Helicobacter pylori.()
-O'Gara EA, Maslin DJ, Nevill AM, Hill DJThe effect of simulated gastric environments on the anti-Helicobacter activity of garlic oilJ Appl Microbiol.(2008 May)
-Liu S, Sun Y, Li W, Yu H, Li X, Liu Z, Zeng J, Zhou Y, Chen C, Jia JThe antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infectionFEMS Microbiol Lett.(2010 Feb)
-McNulty CA, Wilson MP, Havinga W, Johnston B, O'Gara EA, Maslin DJA pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pyloriHelicobacter.(2001 Sep)
-Aydin A, Ersöz G, Tekesin O, Akçiçek E, Tuncyürek MGarlic oil and Helicobacter pylori infectionAm J Gastroenterol.(2000 Feb)
-Graham DY, Anderson SY, Lang TGarlic or jalapeño peppers for treatment of Helicobacter pylori infectionAm J Gastroenterol.(1999 May)
-Gail MH, Pfeiffer RM, Brown LM, Zhang L, Ma JL, Pan KF, Liu WD, You WCGarlic, vitamin, and antibiotic treatment for Helicobacter pylori: a randomized factorial controlled trialHelicobacter.(2007 Oct)

🍔 Печінка - 21 досліджень [544-565]:
-Kim MH, Kim MJ, Lee JH, Han JI, Kim JH, Sok DE, Kim MRHepatoprotective effect of aged black garlic on chronic alcohol-induced liver injury in ratsJ Med Food.(2011 Jul-Aug)
-The protective effects of garlic oil on acute ethanol‐induced oxidative stress in the liver of mice.()
-Nencini C, Franchi GG, Cavallo F, Micheli LProtective effect of Allium neapolitanum Cyr. versus Allium sativum L. on acute ethanol-induced oxidative stress in rat liverJ Med Food.(2010 Apr)
-Sajitha GR, Jose R, Andrews A, Ajantha KG, Augustine P, Augusti KTGarlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of RatsIndian J Clin Biochem.(2010 Jul)
-Ki SH, Choi JH, Kim CW, Kim SGCombined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activityChem Biol Interact.(2007 Aug 30)
-Hattori A, Yamada N, Nishikawa T, Fukuda H, Fujino TProtective effect of ajoene on acetaminophen-induced hepatic injury in miceBiosci Biotechnol Biochem.(2001 Nov)
-Anoush M, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NSThe protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletionPak J Biol Sci.(2009 May 15)
-Kalantari H, Salehi MThe protective effect of garlic oil on hepatotoxicity induced by acetaminophen in mice and comparison with N-acetylcysteineSaudi Med J.(2001 Dec)
-Zhao C, Shichi HPrevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteineJ Ocul Pharmacol Ther.(1998 Aug)
-Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AICytochrome P450 2E1 contributes to ethanol-induced fatty liver in miceHepatology.(2008 May)
-Liu LG, Yan H, Yao P, Zhang W, Zou LJ, Song FF, Li K, Sun XFCYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytesWorld J Gastroenterol.(2005 Aug 7)
-Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn ICytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liverHepatology.(2005 Feb)
-Shimada M, Liu L, Nussler N, Jonas S, Langrehr JM, Ogawa T, Kaminishi M, Neuhaus P, Nussler AKHuman hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibitionToxicol Lett.(2006 Jun 1)
-Nussler AK, Hao L, Knobeloch D, Yao P, Nussler NC, Wang Z, Liu L, Ehnert SProtective role of HO-1 for alcohol-dependent liver damageDig Dis.(2010)
-Yao P, Nussler A, Liu L, Hao L, Song F, Schirmeier A, Nussler NQuercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathwaysJ Hepatol.(2007 Aug)
-Gong P, Cederbaum AI, Nieto NHeme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicityFree Radic Biol Med.(2004 Feb 1)
-Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SGRole of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethionesHepatology.(2009 Jun)
-Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang MAMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceCell Metab.(2011 Apr 6)
-Xiao J, Ching YP, Liong EC, Nanji AA, Fung ML, Tipoe GLGarlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal modelEur J Nutr.(2013 Feb)
-The hepatopulmonary syndrome: new name, old complexities.()
-De BK, Dutta D, Pal SK, Gangopadhyay S, Das Baksi S, Pani AThe role of garlic in hepatopulmonary syndrome: a randomized controlled trialCan J Gastroenterol.(2010 Mar)

🥤 Нирки - 6 досліджень [565-571]:
-Sivaskandarajah GA, Jeansson M, Maezawa Y, Eremina V, Baelde HJ, Quaggin SEVegfa protects the glomerular microvasculature in diabetesDiabetes.(2012 Nov)
-Cellier E, Mage M, Duchêne J, Pécher C, Couture R, Bascands JL, Girolami JPBradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylationAm J Physiol Renal Physiol.(2003 Feb)
-Nogueira CW, Soares FA, Nascimento PC, Muller D, Rocha JB2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydrataseToxicology.(2003 Mar 3)
-Brito VB, Folmer V, Soares JC, Silveira ID, Rocha JBLong-term sucrose and glucose consumption decreases the delta-aminolevulinate dehydratase activity in miceNutrition.(2007 Nov-Dec)
-Saravanan G, Ponmurugan P, Begum MSEffect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic ratsJ Trace Elem Med Biol.(2013 Apr)
-Shiju TM, Rajesh NG, Viswanathan PRenoprotective effect of aged garlic extract in streptozotocin-induced diabetic ratsIndian J Pharmacol.(2013 Jan-Feb)

📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали (ч.3):

👇 Компонент №4 - Capsaicin (capsacinoids), piperine (piper nigrum) mixture (капсаїцин, піперин, каєнський перець, чорний перець) 🌿:

🥗🤩 Схуднення, зменшення ваги, жироспалювання, зайва вага, контроль апетиту, жировий (ліпідний) обмін - 20 досліджень [571-591]:
 - Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki MEffects of red-pepper diet on the energy metabolism in menJ Nutr Sci Vitaminol (Tokyo).(1995 Dec)
 - Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, Yan ZC, Wang LJ, Zhao ZG, Zhu SJ, Schrader M, Thilo F, Zhu ZM, Tepel MActivation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesityCirc Res.(2007 Apr 13)
 - Watanabe T, Sakurada N, Kobata KCapsaicin-, resiniferatoxin-, and olvanil-induced adrenaline secretions in rats via the vanilloid receptorBiosci Biotechnol Biochem.(2001 Nov)
 - Watanabe T, Kawada T, Kurosawa M, Sato A, Iwai KAdrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in ratsAm J Physiol.(1988 Jul)
 - Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai KCapsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilizationProc Soc Exp Biol Med.(1986 Nov)
 - Shin KO, Moritani TAlterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy menJ Nutr Sci Vitaminol (Tokyo).(2007 Apr)
 - Yoshioka M, St-Pierre S, Suzuki M, Tremblay AEffects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese womenBr J Nutr.(1998 Dec)
 - Kim KM, Kawada T, Ishihara K, Inoue K, Fushiki TIncrease in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretionBiosci Biotechnol Biochem.(1997 Oct)
 - Osaka T, Lee TH, Kobayashi A, Inoue S, Kimura SThermogenesis mediated by a capsaicin-sensitive area in the ventrolateral medullaNeuroreport.(2000 Aug 3)
 - Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats.()
 - Hursel R, Westerterp-Plantenga MSThermogenic ingredients and body weight regulationInt J Obes (Lond).(2010 Apr)
 - Rao VR, Raju SS, Sarma VU, Sabine F, Babu KH, Babu KS, Rao JMSimultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDANat Prod Res.(2011 Aug)
 - Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PSInfluence of piperine on the pharmacokinetics of curcumin in animals and human volunteersPlanta Med.(1998 May)
 - Han HKThe effects of black pepper on the intestinal absorption and hepatic metabolism of drugsExpert Opin Drug Metab Toxicol.(2011 Jun)
 - Bajad S, Bedi KL, Singla AK, Johri RKPiperine inhibits gastric emptying and gastrointestinal transit in rats and micePlanta Med.(2001 Mar)
 - Ononiwu IM, Ibeneme CE, Ebong OOEffects of piperine on gastric acid secretion in albino ratsAfr J Med Med Sci.(2002 Dec)
 - Black pepper [piper nigrum.()
 - Lack of Adverse Influence of Black Pepper, Its Oleoresin and Piperine in the Weanling Rat.()
 - Piyachaturawat P, Glinsukon T, Toskulkao CAcute and subacute toxicity of piperine in mice, rats and hamstersToxicol Lett.(1983 May)
 - Srinivasan KBlack pepper and its pungent principle-piperine: a review of diverse physiological effectsCrit Rev Food Sci Nutr.(2007)

🏋️💪 Спорт, тренування, м'язи, відновлення, катаболізм, анаболізм - 7 досліджень [591-598]:
 - Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DSInteraction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsCell.(1996 Mar 8)
 - Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle FCharacterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal musclePLoS One.(2013)
 - Xin H, Tanaka H, Yamaguchi M, Takemori S, Nakamura A, Kohama KVanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscleBiochem Biophys Res Commun.(2005 Jul 8)
 - Heck DE*NO, RSNO, ONOO-, NO+, *NOO, NOx--dynamic regulation of oxidant scavenging, nitric oxide stores, and cyclic GMP-independent cell signalingAntioxid Redox Signal.(2001 Apr)
 - Luo Z, Ma L, Zhao Z, He H, Yang D, Feng X, Ma S, Chen X, Zhu T, Cao T, Liu D, Nilius B, Huang Y, Yan Z, Zhu ZTRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in miceCell Res.(2012 Mar)
 - Ito N, Ruegg UT, Kudo A, Miyagoe-Suzuki Y, Takeda SActivation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophyNat Med.(2013 Jan)
 - Oh TW, Oh TW, Ohta FDose-dependent effect of capsaicin on endurance capacity in ratsBr J Nutr.(2003 Sep)

🏋️‍♀️ Наднирники - 7 досліджень [598-605]:
 - Watanabe T, Kawada T, Yamamoto M, Iwai KCapsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized ratsBiochem Biophys Res Commun.(1987 Jan 15)
 - Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe TA nonpungent component of steamed ginger--{10}-shogaol--increases adrenaline secretion via the activation of TRPV1Nutr Neurosci.(2006 Jun-Aug)
 - Iwasaki Y, Tanabe M, Kobata K, Watanabe TTRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretionBiosci Biotechnol Biochem.(2008 Oct)
 - Khalil Z, Livett BG, Marley PDThe role of sensory fibres in the rat splanchnic nerve in the regulation of adrenal medullary secretion during stressJ Physiol.(1986 Jan)
 - Sensory fibres modulate histamine-induced catecholamine secretion from the rat adrenal medulla and sympathetic nerves.()
 - Zhou XF, Marley PD, Livett BGRole of capsaicin-sensitive neurons in catecholamine secretion from rat adrenal glandsEur J Pharmacol.(1990 Sep 21)
 - Takahashi K, Toyohira Y, Ueno S, Tsutsui M, Yanagihara NCapsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cellsNaunyn Schmiedebergs Arch Pharmacol.(2006 Nov)

👇 Компонент №5 - Zingiber officinale roscoe (екстракт зінгіберу лікарського, імбир) 🌿:

🧠 Пам'ять: короткострокова і довгострокова, процеси навчання, сприйняття і засвоєння інформації - 2 дослідження [605-607]:
 - Saenghong N, Wattanathorn J, Muchimapura S, Tongun T, Piyavhatkul N, Banchonglikitkul C, Kajsongkram TZingiber officinale Improves Cognitive Function of the Middle-Aged Healthy WomenEvid Based Complement Alternat Med.(2012)
 - Wattanathorn J, Jittiwat J, Tongun T, Muchimapura S, Ingkaninan KZingiber officinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic RatEvid Based Complement Alternat Med.(2011)

🥗🩸 Обмін речовин, регуляція цукру в крові, глюкоза, цукровий діабет, інсулінорезистентність, предіабет, профілактика діабету, моторика шлунку, ШКТ - 9 досліджень [607-616]:
 - Heimes K, Feistel B, Verspohl EJImpact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extractsEur J Pharmacol.(2009 Dec 10)
 - Akhani SP, Vishwakarma SL, Goyal RKAnti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic ratsJ Pharm Pharmacol.(2004 Jan)
 - Gonlachanvit S, Chen YH, Hasler WL, Sun WM, Owyang CGinger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandinsJ Pharmacol Exp Ther.(2003 Dec)
 - Mansour MS, Ni YM, Roberts AL, Kelleman M, Roychoudhury A, St-Onge MPGinger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: A pilot studyMetabolism.(2012 Apr 24)
 - Stewart JJ, Wood MJ, Wood CD, Mims MEEffects of ginger on motion sickness susceptibility and gastric functionPharmacology.(1991)
 - Shariatpanahi ZV, Taleban FA, Mokhtari M, Shahbazi SGinger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unitJ Crit Care.(2010 Dec)
 - Hu ML, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, Chiu YC, Chiu KW, Hu THEffect of ginger on gastric motility and symptoms of functional dyspepsiaWorld J Gastroenterol.(2011 Jan 7)
 - Micklefield GH, Redeker Y, Meister V, Jung O, Greving I, May BEffects of ginger on gastroduodenal motilityInt J Clin Pharmacol Ther.(1999 Jul)
 - Lohsiriwat S, Rukkiat M, Chaikomin R, Leelakusolvong SEffect of ginger on lower esophageal sphincter pressureJ Med Assoc Thai.(2010 Mar)

🍌 Ерекція, потенція, лібідо, сексуальна (інтимна) сила, афродизіак, фертильність, тестостерон - 13 досліджень [616-629]:
 - Kamtchouing P, Mbongue Fandio GY, Dimo T, Jatsa HBEvaluation of androgenic activity of Zingiber officinale and Pentadiplandra brazzeana in male ratsAsian J Androl.(2002 Dec)
 - Effects of Zingiber Officinale on Reproductive Functions in the Male Rat.()
 - The effects of ginger on spermatogenesis and sperm parameters of rat.()
 - A 35-day gavage safety assessment of ginger in rats.()
 - Shukla Y, Prasad S, Tripathi C, Singh M, George J, Kalra NIn vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by (6)-gingerolMol Nutr Food Res.(2007 Dec)
 - Moselhy WA, Helmy NA, Abdel-Halim BR, Nabil TM, Abdel-Hamid MIRole of ginger against the reproductive toxicity of aluminium chloride in albino male ratsReprod Domest Anim.(2012 Apr)
 - Shalaby MA, Hamowieh ARSafety and efficacy of Zingiber officinale roots on fertility of male diabetic ratsFood Chem Toxicol.(2010 Oct)
 - Amin A, Hamza AAEffects of Roselle and Ginger on cisplatin-induced reproductive toxicity in ratsAsian J Androl.(2006 Sep)
 - Amin A, Hamza AA, Kambal A, Daoud SHerbal extracts counteract cisplatin-mediated cell death in rat testisAsian J Androl.(2008 Mar)
 - Backon JGinger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone bindingEur J Obstet Gynecol Reprod Biol.(1991 Nov 26)
 - Winters SJ, Banks JL, Loriaux DLCimetidine is an antiandrogen in the ratGastroenterology.(1979 Mar)
 - The effect of Ginger on semen parameters and serum FSH, LH & testosterone of infertile men.()
 - Kim IG, Kang SC, Kim KC, Choung ES, Zee OPScreening of estrogenic and antiestrogenic activities from medicinal plantsEnviron Toxicol Pharmacol.(2008 Jan)