⚫️ Наукові дослідження та матеріали:
📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали:
👇 Компонент №1 - St. John’s wort, linnean, hypericum perforatum, matured hop, passiflora incarnata (звіробій, екстракт шишок хмелю, екстракт пасифлори)🌿:
😞 Депресія, стрес, неврозність, тривожність, пригніченість, печаль, роздратованість, астенія (вигорання), поганий настрій, апатія (відсутність мотивації), проблеми зі сном, серотонін, дофамін, норадреналін - 7 досліджень [1-7]:
- Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis - J Affect Disord (2017-Mar-01)
- Zhao X, et al. The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials - Adv Clin Exp Med (2022-Oct-11)
- Knüppel L, Linde K. Adverse effects of St. John's Wort: a systematic review - J Clin Psychiatry (2004-Nov)
- Knüppel L, Linde K. Adverse effects of St. John's Wort: a systematic review -
J Clin Psychiatry (2004-Nov)
- Bonaterra GA, et al. Neurotrophic, Cytoprotective, and Anti-inflammatory Effects of St. John's Wort Extract on Differentiated Mouse Hippocampal HT-22 Neurons - Front Pharmacol (2017)
- Singer A, Wonnemann M, Müller WE. Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1 - J Pharmacol Exp Ther (1999-Sep)
- Peterson B, Nguyen H. St John's Wort - StatPearls (2023-05)
👇 Компонент №2 - Mentha piperita (м'ята перечна) 🌿:
😥 Стрес, напруга, невроз, тривога, генералізований тривожний розлад, кортизол головний біль, мігрень - 17 досліджень [7-24]:
- Kligler B, Chaudhary SPeppermint oilAm Fam Physician.(2007 Apr 1)
- Göbel H, Fresenius J, Heinze A, Dworschak M, Soyka DEffectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension typeNervenarzt.(1996 Aug)
- Göbel H, Schmidt G, Soyka DEffect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parametersCephalalgia.(1994 Jun)
- MacDougall JM, Fandrick K, Zhang X, Serafin SV, Cashman JRInhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analoguesChem Res Toxicol.(2003 Aug)
- Ghazi AM, Salhab AS, Arafat TA, Irshaid YMEffect of mint drink on metabolism of nicotine as measured by nicotine to cotinine ratio in urine of Jordanian smoking volunteersNicotine Tob Res.(2011 Aug)
- Hukkanen J, Jacob P 3rd, Benowitz NLMetabolism and disposition kinetics of nicotinePharmacol Rev.(2005 Mar)
- Dresser GK, Wacher V, Wong S, Wong HT, Bailey DGEvaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivoClin Pharmacol Ther.(2002 Sep)
- Kovar KA, Gropper B, Friess D, Ammon HPBlood levels of 1,8-cineole and locomotor activity of mice after inhalation and oral administration of rosemary oilPlanta Med.(1987 Aug)
- Moss M, Hewitt S, Moss L, Wesnes KModulation of cognitive performance and mood by aromas of peppermint and ylang-ylangInt J Neurosci.(2008 Jan)
- Effects of Peppermint Scent Administration on Cognitive Video Game Performance.()
- Heuberger E, Ilmberger JThe influence of essential oils on human vigilanceNat Prod Commun.(2010 Sep)
- Varney E, Buckle JEffect of inhaled essential oils on mental exhaustion and moderate burnout: a small pilot studyJ Altern Complement Med.(2013 Jan)
- Lane B, Cannella K, Bowen C, Copelan D, Nteff G, Barnes K, Poudevigne M, Lawson JExamination of the effectiveness of peppermint aromatherapy on nausea in women post C-sectionJ Holist Nurs.(2012 Jun)
- Burns EE, Blamey C, Ersser SJ, Barnetson L, Lloyd AJAn investigation into the use of aromatherapy in intrapartum midwifery practiceJ Altern Complement Med.(2000 Apr)
- Tate SPeppermint oil: a treatment for postoperative nauseaJ Adv Nurs.(1997 Sep)
- Anderson LA, Gross JBAromatherapy with peppermint, isopropyl alcohol, or placebo is equally effective in relieving postoperative nauseaJ Perianesth Nurs.(2004 Feb)
- Schoenen J, Timsit-Berthier MContingent negative variation: methods and potential interest in headacheCephalalgia.(1993 Feb)
🍽️😫🚽 Спазми, ШКТ, шлунок, біль в шлунку, синдром подразненного кишечника (кишківника), розслаблення ШКТ - 30 досліджень [24-53]:
- Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus GroupThe Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensusAm J Gastroenterol.(2006 Aug)
- Patrick LGastroesophageal reflux disease (GERD): a review of conventional and alternative treatmentsAltern Med Rev.(2011 Jun)
- Hills JM, Aaronson PIThe mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pigGastroenterology.(1991 Jul)
- Inamori M, Akiyama T, Akimoto K, Fujita K, Takahashi H, Yoneda M, Abe Y, Kubota K, Saito S, Ueno N, Nakajima AEarly effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system)J Gastroenterol.(2007 Jul)
- Iida H, Inamori M, Uchiyama T, Endo H, Hosono K, Akiyama T, Sakamoto Y, Fujita K, Takahashi H, Yoneda M, Koide T, Tokoro C, Goto A, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima AEarly effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH valuesHepatogastroenterology.(2011 Jan-Feb)
- Rees WD, Evans BK, Rhodes JTreating irritable bowel syndrome with peppermint oilBr Med J.(1979 Oct 6)
- Hiki N, Kaminishi M, Yasuda K, Uedo N, Honjo H, Matsuhashi N, Hiratsuka T, Sekine C, Nomura S, Yahagi N, Tajiri H, Suzuki HAntiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled studyGastrointest Endosc.(2011 May)
- Hiki N, Kaminishi M, Tanabe S, Fujisaki J, Yoshino J, Iguchi M, Kobayashi H, Ashida K, Kawabe T, Kawano T, Nomura S, Yahagi N, Tajiri H, Suzuki HAn open-label, single-arm study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopyJ Gastroenterol.(2011 Jul)
- Hiki N, Kaminishi M, Yasuda K, Uedo N, Kobari M, Sakai T, Hiratsuka T, Ohno K, Honjo H, Nomura S, Yahagi N, Tajiri H, Suzuki HMulticenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopyDig Endosc.(2012 Mar)
- Rösch W, Liebregts T, Gundermann KJ, Vinson B, Holtmann GPhytotherapy for functional dyspepsia: a review of the clinical evidence for the herbal preparation STW 5Phytomedicine.(2006)
- von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner PSTW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind studyAm J Gastroenterol.(2007 Jun)
- Madisch A, Holtmann G, Mayr G, Vinson B, Hotz JTreatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trialDigestion.(2004)
- May B, Kuntz HD, Kieser M, Köhler SEfficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsiaArzneimittelforschung.(1996 Dec)
- May B, Köhler S, Schneider BEfficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsiaAliment Pharmacol Ther.(2000 Dec)
- Holtmann G, Haag S, Adam B, Funk P, Wieland V, Heydenreich CJEffects of a fixed combination of peppermint oil and caraway oil on symptoms and quality of life in patients suffering from functional dyspepsiaPhytomedicine.(2003)
- Micklefield GH, Greving I, May BEffects of peppermint oil and caraway oil on gastroduodenal motilityPhytother Res.(2000 Feb)
- Micklefield G, Jung O, Greving I, May BEffects of intraduodenal application of peppermint oil (WS(R) 1340) and caraway oil (WS(R) 1520) on gastroduodenal motility in healthy volunteersPhytother Res.(2003 Feb)
- Fixed peppermint oil/caraway oil combination in functional dyspepsia – efficacy unaffected by H. pylori status.()
- Forster HB, Niklas H, Lutz SAntispasmodic effects of some medicinal plantsPlanta Med.(1980 Dec)
- Reiter M, Brandt WRelaxant effects on tracheal and ileal smooth muscles of the guinea pigArzneimittelforschung.(1985)
- Giachetti D, Taddei E, Taddei IPharmacological activity of essential oils on Oddi's sphincterPlanta Med.(1988 Oct)
- Evans BK, Heatley RV, James KC, Luscombe DKProceedings: Further studies on the correlation between biological activity and solubility of some carminativesJ Pharm Pharmacol.(1975 Dec)
- Shavakhi A, Ardestani SK, Taki M, Goli M, Keshteli AHPremedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial studyActa Gastroenterol Belg.(2012 Sep)
- Suares NC, Ford ACDiagnosis and treatment of irritable bowel syndromeDiscov Med.(2011 May)
- Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.()
- Liu JH, Chen GH, Yeh HZ, Huang CK, Poon SKEnteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trialJ Gastroenterol.(1997 Dec)
- Lech Y, Olesen KM, Hey H, Rask-Pedersen E, Vilien M, Ostergaard OTreatment of irritable bowel syndrome with peppermint oil. A double-blind study with a placeboUgeskr Laeger.(1988 Oct 3)
- Cappello G, Spezzaferro M, Grossi L, Manzoli L, Marzio LPeppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trialDig Liver Dis.(2007 Jun)
- Alam MS, Roy PK, Miah AR, Mollick SH, Khan MR, Mahmud MC, Khatun SEfficacy of Peppermint oil in diarrhea predominant IBS - a double blind randomized placebo - controlled studyMymensingh Med J.(2013 Jan)
- Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh RThe effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndromeDig Dis Sci.(2010 May)
🍌 Гормональне здоров'я, тестостерон, лютенізуючий гормон, фолікулостимулюючий гормон - 14 досліджень [53-67]:
- Forster HB, Niklas H, Lutz SAntispasmodic effects of some medicinal plantsPlanta Med.(1980 Dec)
- Reiter M, Brandt WRelaxant effects on tracheal and ileal smooth muscles of the guinea pigArzneimittelforschung.(1985)
- Giachetti D, Taddei E, Taddei IPharmacological activity of essential oils on Oddi's sphincterPlanta Med.(1988 Oct)
- Evans BK, Heatley RV, James KC, Luscombe DKProceedings: Further studies on the correlation between biological activity and solubility of some carminativesJ Pharm Pharmacol.(1975 Dec)
- Shavakhi A, Ardestani SK, Taki M, Goli M, Keshteli AHPremedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial studyActa Gastroenterol Belg.(2012 Sep)
- Suares NC, Ford ACDiagnosis and treatment of irritable bowel syndromeDiscov Med.(2011 May)
- Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.()
- Liu JH, Chen GH, Yeh HZ, Huang CK, Poon SKEnteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trialJ Gastroenterol.(1997 Dec)
- Lech Y, Olesen KM, Hey H, Rask-Pedersen E, Vilien M, Ostergaard OTreatment of irritable bowel syndrome with peppermint oil. A double-blind study with a placeboUgeskr Laeger.(1988 Oct 3)
- Cappello G, Spezzaferro M, Grossi L, Manzoli L, Marzio LPeppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trialDig Liver Dis.(2007 Jun)
- Alam MS, Roy PK, Miah AR, Mollick SH, Khan MR, Mahmud MC, Khatun SEfficacy of Peppermint oil in diarrhea predominant IBS - a double blind randomized placebo - controlled studyMymensingh Med J.(2013 Jan)
- Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh RThe effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndromeDig Dis Sci.(2010 May)
- Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş NEffect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutismPhytother Res.(2007 May)
- Akdogan M, Ozguner M, Kocak A, Oncu M, Cicek EEffects of peppermint teas on plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels and testicular tissue in ratsUrology.(2004 Aug)
👇 Компонент №3 - Hawthorn extract (екстракт плодів глоту) 🌿:
🩸 Кровотік, розрідження крові, ліпіди, тромби, атеросклероз, цукор в крові, інсулінорезистентність, цукровий діабет, схуднення, зайва вага - 27 досліджень [67-94]:
- Song SJ, Li LZ, Gao PY, Yuan YQ, Wang RP, Liu KC, Peng YIsolation of Antithrombotic Phenolic Compounds from the Leaves of Crataegus pinnatifidaPlanta Med.(2012 Oct 31)
- Liu P, Kallio H, Lü D, Zhou C, Ou S, Yang BAcids, sugars, and sugar alcohols in Chinese hawthorn (Crataegus spp.) fruitsJ Agric Food Chem.(2010 Jan 27)
- Extraction optimization, purification and antioxidant activity of procyanidins from hawthorn (C. pinnatifida Bge. var. major) fruits.()
- Quality and antioxidant activity detection of Crataegus leaves using on-line high-performance liquid chromatography with diode array detector coupled to chemiluminescence detection.()
- A new biphenyl glucoside from the leaves of Crataegus pinnatifida.()
- Min BS, Huong HT, Kim JH, Jun HJ, Na MK, Nam NH, Lee HK, Bae K, Kang SSFuro-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activityPlanta Med.(2004 Dec)
- Zhang PC, Xu SXFlavonoid ketohexosefuranosides from the leaves of Crataegus pinnatifida Bge. var. major N.E.BrPhytochemistry.(2001 Aug)
- Zhang PC, Zhou YJ, Xu SXTwo novel flavonoid glycosides from Crataegus pinnatifida Bge.var.major N.E.BrJ Asian Nat Prod Res.(2001)
- Jurikova T, Sochor J, Rop O, Mlcek J, Balla S, Szekeres L, Adam V, Kizek RPolyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE) FruitsMolecules.(2012 Dec 6)
- Cui T, Li JZ, Kayahara H, Ma L, Wu LX, Nakamura KQuantification of the polyphenols and triterpene acids in chinese hawthorn fruit by high-performance liquid chromatographyJ Agric Food Chem.(2006 Jun 28)
- Ye XL, Huang WW, Chen Z, Li XG, Li P, Lan P, Wang L, Gao Y, Zhao ZQ, Chen XSynergetic effect and structure-activity relationship of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors from Crataegus pinnatifida BgeJ Agric Food Chem.(2010 Mar 10)
- Cheng S, Qiu F, Huang J, He JSimultaneous determination of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves by RP-HPLC with ultraviolet photodiode array detectionJ Sep Sci.(2007 Mar)
- Kao ES, Wang CJ, Lin WL, Yin YF, Wang CP, Tseng THAnti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivoJ Agric Food Chem.(2005 Jan 26)
- Wang T, An Y, Zhao C, Han L, Boakye-Yiadom M, Wang W, Zhang YRegulation effects of Crataegus pinnatifida leaf on glucose and lipids metabolismJ Agric Food Chem.(2011 May 11)
- Liu RH, Yu BYStudy on the chemical constituents of the leaves from Crataegus pinnatifida Bge. var. major N. E. BrZhong Yao Cai.(2006 Nov)
- Ahn KS, Hahm MS, Park EJ, Lee HK, Kim IHCorosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agentPlanta Med.(1998 Jun)
- Min BS, Kim YH, Lee SM, Jung HJ, Lee JS, Na MK, Lee CO, Lee JP, Bae KCytotoxic triterpenes from Crataegus pinnatifidaArch Pharm Res.(2000 Apr)
- Zhou XJ, Hu XM, Yi YM, Wan JPreparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticlesDrug Dev Ind Pharm.(2009 Mar)
- Lin Y, Vermeer MA, Trautwein EATriterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in HamstersEvid Based Complement Alternat Med.(2011)
- Ma G, Jiang XH, Chen Z, Ren J, Li CR, Liu TMSimultaneous determination of vitexin-4''-O-glucoside and vitexin-2''-O-rhamnoside from Hawthorn leaves flavonoids in rat plasma by HPLC method and its application to pharmacokinetic studiesJ Pharm Biomed Anal.(2007 May 9)
- Chu CY, Lee MJ, Liao CL, Lin WL, Yin YF, Tseng THInhibitory effect of hot-water extract from dried fruit of Crataegus pinnatifida on low-density lipoprotein (LDL) oxidation in cell and cell-free systemsJ Agric Food Chem.(2003 Dec 17)
- Ying XX, Wang F, Cheng ZZ, Zhang WJ, Li HB, Du Y, Liu X, Wang SY, Kang TGPharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous applicationEur J Drug Metab Pharmacokinet.(2012 Jun)
- Liu X, Wang D, Wang SY, Meng XS, Zhang WJ, Ying XX, Kang TGLC determination and pharmacokinetic study of hyperoside in rat plasma after intravenous administrationYakugaku Zasshi.(2010 Jun)
- Tao W, Deqin Z, Yuhong L, Hong L, Zhanbiao L, Chunfeng Z, Limin H, Xiumei GRegulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese MedicineJ Ethnopharmacol.(2010 Apr 21)
- Niu C, Chen C, Chen L, Cheng K, Yeh C, Cheng JDecrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPARα in liver of mice fed high-fat dietHorm Metab Res.(2011 Aug)
- Kuo DH, Yeh CH, Shieh PC, Cheng KC, Chen FA, Cheng JTEffect of shanzha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat dietJ Ethnopharmacol.(2009 Jul 30)
- Huang W, Ye X, Li X, Zhao Z, Lan P, Wang L, Liu M, Gao Y, Zhu J, Li P, Feng PThe inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductaseZhongguo Zhong Yao Za Zhi.(2010 Sep)
🛡️🦠 Імунітет, запалення, інфекції, віруси, суглоби - 4 дослідження [94-98]:
- Li C, Wang MHAnti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cellsNutr Res Pract.(2011 Apr)
- Kim SJ, Um JY, Lee JYAnti-inflammatory activity of hyperoside through the suppression of nuclear factor-κB activation in mouse peritoneal macrophagesAm J Chin Med.(2011)
- Moon HI, Kim TI, Cho HS, Kim EKIdentification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifidaBioorg Med Chem Lett.(2010 Feb 1)
- Tadić VM, Dobrić S, Marković GM, Dordević SM, Arsić IA, Menković NR, Stević TAnti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extractJ Agric Food Chem.(2008 Sep 10)
👁👓 Зір, очі, офтальмологія - 1 дослідження [94-95]:
- Wang T, Zhang P, Zhao C, Zhang Y, Liu H, Hu L, Gao X, Zhang DPrevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro of Crataegus pinnatifida leavesBiol Trace Elem Res.(2011 Jul)
🌬️ Легені - 1 дослідження [95-96]:
- Shin IS, Lee MY, Lim HS, Ha H, Seo CS, Kim JC, Shin HKAn extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthmaPLoS One.(2012)
🍽️ ШКТ, шлунок - 1 дослідження [96-97]:
- Tadić VM, Dobrić S, Marković GM, Dordević SM, Arsić IA, Menković NR, Stević TAnti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extractJ Agric Food Chem.(2008 Sep 10)
- Wang T, An Y, Zhao C, Han L, Boakye-Yiadom M, Wang W, Zhang YRegulation effects of Crataegus pinnatifida leaf on glucose and lipids metabolismJ Agric Food Chem.(2011 May 11)
🍔 Печінка - 1 дослідження [97-98]:
- Kwon HJ, Kim YY, Choung SYAmelioration effects of traditional Chinese medicine on alcohol-induced fatty liverWorld J Gastroenterol.(2005 Sep 21)
😊 Шкіра - 1 дослідження [98-99]:
- Kao ES, Wang CJ, Lin WL, Chu CY, Tseng THEffects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester applicationFood Chem Toxicol.(2007 Oct)
💇♀️ Волосся - 1 дослідження [99-100]:
- Shin HS, Lee JM, Park SY, Yang JE, Kim JH, Yi THHair Growth Activity of Crataegus pinnatifida on C57BL/6 Mouse ModelPhytother Res.(2012 Nov 12)
👇 Компонент №4 - Valeriana officinalis (валеріана лікарська) 🌿:
😥 Стрес, напруга, невроз, тривога, генералізований тривожний розлад, кортизол, ГАМК, глутамат - 27 досліджень [100-127]:
-Houghton PJThe scientific basis for the reputed activity of ValerianJ Pharm Pharmacol.(1999 May)
-Salter S, Brownie STreating primary insomnia - the efficacy of valerian and hopsAust Fam Physician.(2010 Jun)
-Mathela CS, Tiwari M, Sammal SS, Chanotiya CSValeriana wallichii DC, a new chemotype from northwestern HimalayaJ Essent Oil Res.(2005 Nov-Dec)
-Navarrete A, Avula B, Choi YW, Khan IAChemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detectionJ AOAC Int.(2006 Jan-Feb)
-Donovan JL, DeVane CL, Chavin KD, Wang JS, Gibson BB, Gefroh HA, Markowitz JSMultiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteersDrug Metab Dispos.(2004 Dec)
-Del Valle-Mojica LM, Ayala-Marín YM, Ortiz-Sanchez CM, Torres-Hernández BA, Abdalla-Mukhaimer S, Ortiz JGSelective Interactions of Valeriana officinalis Extracts and Valerenic Acid with {H}Glutamate Binding to Rat Synaptic MembranesEvid Based Complement Alternat Med.(2011)
-Schumacher B, Scholle S, Hölzl J, Khudeir N, Hess S, Müller CELignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptorsJ Nat Prod.(2002 Oct)
-Bodesheim U, Hölzl JIsolation and receptor binding properties of alkaloids and lignans from Valeriana officialis LPharmazie.(1997 May)
-Wang PC, Ran XH, Chen R, Li LC, Xiong SS, Liu YQ, Luo HR, Zhou J, Zhao YXVolvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalisTetrahedron Lett.(2010)
-Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNSPharmacol Biochem Behav.(2003 Jun)
-Fernández S, Wasowski C, Paladini AC, Marder MSedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalisPharmacol Biochem Behav.(2004 Feb)
-Goppel M, Franz GStability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignansPharmazie.(2004 Jun)
-Taibi DM, Bourguignon C, Gill Taylor AA feasibility study of valerian extract for sleep disturbance in person with arthritisBiol Res Nurs.(2009 Apr)
-Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, Sancho-Gómez P, Calbó-Caldentey C, Flores-Mateo GEffectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trialsSleep Med.(2010 Jun)
-Barton DL, Atherton PJ, Bauer BA, Moore DF Jr, Mattar BI, Lavasseur BI, Rowland KM Jr, Zon RT, Lelindqwister NA, Nagargoje GG, Morgenthaler TI, Sloan JA, Loprinzi CLThe use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5)J Support Oncol.(2011 Jan-Feb)
-Balderer G, Borbély AAEffect of valerian on human sleepPsychopharmacology (Berl).(1985)
-Leathwood PD, Chauffard FAqueous extract of valerian reduces latency to fall asleep in manPlanta Med.(1985 Apr)
-Abourashed EA, Koetter U, Brattström AIn vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptorsPhytomedicine.(2004 Nov)
-Müller CE, Schumacher B, Brattström A, Abourashed EA, Koetter UInteractions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptorsLife Sci.(2002 Sep 6)
-Maroo N, Hazra A, Das TEfficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trialIndian J Pharmacol.(2013 Jan-Feb)
-Melzer J, Schrader E, Brattström A, Schellenberg R, Saller RFixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trialPhytother Res.(2009 Sep)
-Hellum BH, Hu Z, Nilsen OGThe induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytesBasic Clin Pharmacol Toxicol.(2007 Jan)
-Hellum BH, Hu Z, Nilsen OGTrade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytesBasic Clin Pharmacol Toxicol.(2009 Jul)
-Gurley BJ
- Miyasaka LS, Atallah AN, Soares BGValerian for anxiety disordersCochrane Database Syst Rev.(2006 Oct 18)
- Felgentreff F, Becker A, Meier B, Brattström AValerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activityPhytomedicine.(2012 Oct 15)
- Andreatini R, Sartori VA, Seabra ML, Leite JREffect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot studyPhytother Res.(2002 Nov)
😃 Покращення настрою, антидепресивні ефекти, регуляція самопочуття, заспокоєння, покращення сну, серотонін, депресія, погіршення настрою, відсутність мотивації, втрата інтересу до життя, психологічний та фізичний дистрес- 10 досліджень [127-137]:
-Abourashed EA, Koetter U, Brattström AIn vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptorsPhytomedicine.(2004 Nov)
-Müller CE, Schumacher B, Brattström A, Abourashed EA, Koetter UInteractions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptorsLife Sci.(2002 Sep 6)
-Maroo N, Hazra A, Das TEfficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trialIndian J Pharmacol.(2013 Jan-Feb)
-Melzer J, Schrader E, Brattström A, Schellenberg R, Saller RFixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trialPhytother Res.(2009 Sep)
-Hellum BH, Hu Z, Nilsen OGThe induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytesBasic Clin Pharmacol Toxicol.(2007 Jan)
-Hellum BH, Hu Z, Nilsen OGTrade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytesBasic Clin Pharmacol Toxicol.(2009 Jul)
-Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Khan IA, Shah AIn vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypesClin Pharmacol Ther.(2005 May)
-Budzinski JW, Foster BC, Vandenhoek S, Arnason JTAn in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tincturesPhytomedicine.(2000 Jul)
-Mohamed ME, Frye RFInhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activitiesDrug Metab Dispos.(2011 Sep)
-Dietz BM, Mahady GB, Pauli GF, Farnsworth NRValerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitroBrain Res Mol Brain Res.(2005 Aug 18)
🌙 Сон, проблеми зі сном, покращення сну, нічні пробудження, ранні пробудження, важко заснути - 20 досліджень [137-157]:
- Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SRAn internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomniaMedicine (Baltimore).(2005 Jul)
- Taibi DM, Vitiello MV, Barsness S, Elmer GW, Anderson GD, Landis CAA randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomniaSleep Med.(2009 Mar)
- Leathwood PD, Chauffard F, Heck E, Munoz-Box RAqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in manPharmacol Biochem Behav.(1982 Jul)
- Leathwood PD, Chauffard FQuantifying the effects of mild sedativesJ Psychiatr Res.(1982-1983)
- Schulz H, Stolz C, Müller JThe effect of valerian extract on sleep polygraphy in poor sleepers: a pilot studyPharmacopsychiatry.(1994 Jul)
- Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots ICritical evaluation of the effect of valerian extract on sleep structure and sleep qualityPharmacopsychiatry.(2000 Mar)
- Francis AJ, Dempster RJEffect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trialPhytomedicine.(2002 May)
- Poyares DR, Guilleminault C, Ohayon MM, Tufik SCan valerian improve the sleep of insomniacs after benzodiazepine withdrawalProg Neuropsychopharmacol Biol Psychiatry.(2002 Apr)
- Diaper A, Hindmarch IA double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adultsPhytother Res.(2004 Oct)
- Bent S, Padula A, Moore D, Patterson M, Mehling WValerian for sleep: a systematic review and meta-analysisAm J Med.(2006 Dec)
- Taibi DM, Landis CA, Petry H, Vitiello MVA systematic review of valerian as a sleep aid: safe but not effectiveSleep Med Rev.(2007 Jun)
- Stevinson C, Ernst EValerian for insomnia: a systematic review of randomized clinical trialsSleep Med.(2000 Apr 1)
- Sarris J, Byrne GJA systematic review of insomnia and complementary medicineClin Rev.(2011 Apr)
- Roth T, Roehrs TEfficacy and Safety of Sleep-Promoting AgentsSleep Med Clin.(2008 Jun)
- Pakseresht S, Boostani H, Sayyah MExtract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind studyJ Complement Integr Med.(2011 Oct 11)
- Nam SM, Choi JH, Yoo DY, Kim W, Jung HY, Kim JW, Kang SY, Park J, Kim DW, Kim WJ, Yoon YS, Hwang IKValeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidationExp Gerontol.(2013 Sep 18)
- Wheatley DKava and valerian in the treatment of stress-induced insomniaPhytother Res.(2001 Sep)
- Savard J, Morin CMInsomnia in the context of cancer: a review of a neglected problemJ Clin Oncol.(2001 Feb 1)
- Palesh OG, Roscoe JA, Mustian KM, Roth T, Savard J, Ancoli-Israel S, Heckler C, Purnell JQ, Janelsins MC, Morrow GRPrevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology ProgramJ Clin Oncol.(2010 Jan 10)
- Davidson JR, MacLean AW, Brundage MD, Schulze KSleep disturbance in cancer patientsSoc Sci Med.(2002 May)
🚺🌸 Жіноче здоров'я, менструація, менструальний біль - 8 досліджень [157-165]:
- Singh A, Kiran D, Singh H, Nel B, Singh P, Tiwari PPrevalence and severity of dysmenorrhea: a problem related to menstruation, among first and second year female medical studentsIndian J Physiol Pharmacol.(2008 Oct-Dec)
- Unsal A1, Ayranci U, Tozun M, Arslan G, Calik EPrevalence of dysmenorrhea and its effect on quality of life among a group of female university studentsUps J Med Sci.(2010 May)
- Tavallaee M, Joffres MR, Corber SJ, Bayanzadeh M, Rad MMThe prevalence of menstrual pain and associated risk factors among Iranian womenJ Obstet Gynaecol Res.(2011 May)
- Gilani AH, Khan AU, Jabeen Q, Subhan F, Ghafar RAntispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activationJ Ethnopharmacol.(2005 Sep 14)
- Mirabi P, Dolatian M, Mojab F, Majd HAEffects of valerian on the severity and systemic manifestations of dysmenorrheaInt J Gynaecol Obstet.(2011 Dec)
- Mirabi P, Mojab FThe effects of valerian root on hot flashes in menopausal womenIran J Pharm Res.(2013 Winter)
- Taavoni S, Ekbatani N, Kashaniyan M, Haghani HEffect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trialMenopause.(2011 Sep)
- Taavoni S, Nazem Ekbatani N, Haghani HValerian/lemon balm use for sleep disorders during menopauseComplement Ther Clin Pract.(2013 Nov)
