⚫️ Наукові дослідження та матеріали:
📚 Науковий аналіз, експериментальні та лабораторні дослідження, доказові матеріали:
👇 Компонент №1 - VITAMIN C, ascorbic acid (вітамін С) 🌿:
😞 Депресія, стрес, неврозність, тривожність, пригніченість, печаль, роздратованість, астенія (вигорання), поганий настрій, апатія (відсутність мотивації), проблеми зі сном, деменція, Альцгеймер - 21 дослідження [1-21]
- Radak Z, Taylor AW, Ohno H, Goto SAdaptation to exercise-induced oxidative stress: from muscle to brainExerc Immunol Rev.(2001)
- Kovacheva-Ivanova S, Bakalova R, Ribavov SRImmobilization stress enhances lipid peroxidation in the rat lungs. Materials and methodsGen Physiol Biophys.(1994 Dec)
- Oishi K, Yokoi M, Maekawa S, Sodeyama C, Shiraishi T, Kondo R, Kuriyama T, Machida KOxidative stress and haematological changes in immobilized ratsActa Physiol Scand.(1999 Jan)
- Moretti M, Budni J, Dos Santos DB, Antunes A, Daufenbach JF, Manosso LM, Farina M, Rodrigues ALProtective effects of ascorbic acid on behavior and oxidative status of restraint-stressed miceJ Mol Neurosci.(2013 Jan)
- Moretti M, Budni J, Ribeiro CM, Rodrigues ALInvolvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension testEur J Pharmacol.(2012 Jul 15)
- Galeotti N, Ghelardini C, Caldari B, Bartolini AEffect of potassium channel modulators in mouse forced swimming testBr J Pharmacol.(1999 Apr)
- Bortolatto CF, Jesse CR, Wilhelm EA, Nogueira CWInvolvement of potassium channels in the antidepressant-like effect of venlafaxine in miceLife Sci.(2010 Feb 27)
- Binfaré RW, Rosa AO, Lobato KR, Santos AR, Rodrigues ALAscorbic acid administration produces an antidepressant-like effect: evidence for the involvement of monoaminergic neurotransmissionProg Neuropsychopharmacol Biol Psychiatry.(2009 Apr 30)
- Moretti M, Colla A, de Oliveira Balen G, dos Santos DB, Budni J, de Freitas AE, Farina M, Severo Rodrigues ALAscorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stressJ Psychiatr Res.(2012 Mar)
- Cocchi P, Silenzi M, Calabri G, Salvi GAntidepressant Effect of Vitamin CPediatrics.(1980 Apr)
- Brody SHigh-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trialBiol Psychiatry.(2002 Aug 15)
- von Arnim CAF, Herbolsheimer F, Nikolaus F, Peter R, Biesalski HK, Ludolph AC, Riepe M, Nagel GDietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older People in South GermanyJ Alzheimers Dis.(2012)
- Christen YOxidative stress and Alzheimer diseaseAm J Clin Nutr.(2000 Feb)
- Pappolla MA, Omar RA, Kim KS, Robakis NKImmunohistochemical evidence of oxidative (corrected) stress in Alzheimer's diseaseAm J Pathol.(1992 Mar)
- Schipper HM, Cissé S, Stopa EGExpression of heme oxygenase-1 in the senescent and Alzheimer-diseased brainAnn Neurol.(1995 Jun)
- Smith MA, Harris PLR, Sayre LM, Beckman JS, Perry GWidespread Peroxynitrite-Mediated Damage in Alzheimer’s DiseaseJ Neurosci.(1997 Apr)
- Rivière S, Birlouez-Aragon I, Nourhashémi F, Vellas BLow plasma vitamin C in Alzheimer patients despite an adequate dietInt J Geriatr Psychiatry.(1998 Nov)
- Quinn J, Suh J, Moore MM, Kaye J, Frei BAntioxidants in Alzheimer's disease-vitamin C delivery to a demanding brainJ Alzheimers Dis.(2003 Aug)
- Heo JH, Hyon-Lee, Lee KMThe possible role of antioxidant vitamin C in Alzheimer's disease treatment and preventionAm J Alzheimers Dis Other Demen.(2013 Mar)
- Rosales-Corral S, Tan DX, Reiter RJ, Valdivia-Velázquez M, Martínez-Barboza G, Acosta-Martínez JP, Ortiz GGOrally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and EJ Pineal Res.(2003 Sep)
- Harrison FE, Hosseini AH, McDonald MP, May JMVitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type micePharmacol Biochem Behav.(2009 Oct)
💪 Вплив на енергію, активність, ентузіазм, радість, мотивація, бажання, дофамін - 25 досліджень [21-46]:
- Omaye ST, Schaus EE, Kutnink MA, Hawkes WCMeasurement of vitamin C in blood components by high-performance liquid chromatography. Implication in assessing vitamin C statusAnn N Y Acad Sci.(1987)
- Carr AC, Bozonet SM, Pullar JM, Simcock JW, Vissers MCHuman skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrationsAm J Clin Nutr.(2013 Apr)
- Savini I, Rossi A, Pierro C, Avigliano L, Catani MVSVCT1 and SVCT2: key proteins for vitamin C uptakeAmino Acids.(2008 Apr)
- Peternelj TT, Coombes JSAntioxidant supplementation during exercise training: beneficial or detrimentalSports Med.(2011 Dec 1)
- Cupps TR, Fauci ASCorticosteroid-mediated immunoregulation in manImmunol Rev.(1982)
- Davison G, Gleeson MInfluence of acute vitamin C and/or carbohydrate ingestion on hormonal, cytokine, and immune responses to prolonged exerciseInt J Sport Nutr Exerc Metab.(2005 Oct)
- Palmer FM, Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Morrow JDInfluence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathonEur J Appl Physiol.(2003 Mar)
- Carrillo AE, Murphy RJ, Cheung SSVitamin C supplementation and salivary immune function following exercise-heat stressInt J Sports Physiol Perform.(2008 Dec)
- Nakhostin-Roohi B, Babaei P, Rahmani-Nia F, Bohlooli SEffect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2maxJ Sports Med Phys Fitness.(2008 Jun)
- Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JDInfluence of vitamin C supplementation on oxidative and immune changes after an ultramarathonJ Appl Physiol.(2002 May)
- Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjöberg LB, Pedersen BKSupplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscleJ Physiol.(2004 Jul 15)
- Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjöberg LB, Pedersen BKSupplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscleJ Physiol.(2004 Jul 15)
- Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, Neufer PDTranscriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen contentFASEB J.(2001 Dec)
- Steensberg A, Febbraio MA, Osada T, Schjerling P, van Hall G, Saltin B, Pedersen BKInterleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen contentJ Physiol.(2001 Dec 1)
- Petersen EW, Carey AL, Sacchetti M, Steinberg GR, Macaulay SL, Febbraio MA, Pedersen BKAcute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitroAm J Physiol Endocrinol Metab.(2005 Jan)
- Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, Prelovsek O, Hohnen-Behrens C, Watt MJ, James DE, Kemp BE, Pedersen BK, Febbraio MAInterleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseDiabetes.(2006 Oct)
- Bruce CR, Dyck DJCytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alphaAm J Physiol Endocrinol Metab.(2004 Oct)
- van Hall G, Steensberg A, Sacchetti M, Fischer C, Keller C, Schjerling P, Hiscock N, Møller K, Saltin B, Febbraio MA, Pedersen BKInterleukin-6 stimulates lipolysis and fat oxidation in humansJ Clin Endocrinol Metab.(2003 Jul)
- Douglas RM, Hemilä H, Chalker E, Treacy BVitamin C for preventing and treating the common coldCochrane Database Syst Rev.(2007 Jul 18)
- Hemilä H, Chalker EVitamin C for preventing and treating the common coldCochrane Database Syst Rev.(2013 Jan 31)
- Bailey DM, Williams C, Betts JA, Thompson D, Hurst TLOxidative stress, inflammation and recovery of muscle function after damaging exercise: effect of 6-week mixed antioxidant supplementationEur J Appl Physiol.(2011 Jun)
- Ekkekakis P, Lind EExercise does not feel the same when you are overweight: the impact of self-selected and imposed intensity on affect and exertionInt J Obes (Lond).(2006 Apr)
- Huck CJ, Johnston CS, Beezhold BL, Swan PDVitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced dietNutrition.(2012 Jun 5)
- Morrison D, Hughes J, Della Gatta PA, Mason S, Lamon S, Russell AP, Wadley GDVitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humansFree Radic Biol Med.(2015 Dec)
- Marshall RJ, Scott KC, Hill RC, Lewis DD, Sundstrom D, Jones GL, Harper JSupplemental vitamin C appears to slow racing greyhoundsJ Nutr.(2002 Jun)
- Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Viña JOral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performanceAm J Clin Nutr.(2008 Jan)
😫 Стрес, вигорання, гормони стресу, кортизол - 7 досліджень [46-53]:
- Palmer FM, Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Morrow JD, Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon, Eur J Appl Physiol.(2003 Mar)
- Carrillo AE, Murphy RJ, Cheung SS, Vitamin C supplementation and salivary immune function following exercise-heat stress, Int J Sports Physiol Perform.(2008 Dec)
- Nakhostin-Roohi B, Babaei P, Rahmani-Nia F, Bohlooli S, Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max, J Sports Med Phys Fitness.(2008 Jun)
- Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JD, Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon, J Appl Physiol.(2002 May)
- Yfanti C, Fischer CP, Nielsen S, Akerström T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BKRole of vitamin C and E supplementation on IL-6 in response to trainingJ Appl Physiol.(2012 Mar)
- Davison G, Gleeson MThe effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in manEur J Appl Physiol.(2006 Jul)
- Kallner AInfluence of vitamin C status on the urinary excretion of catecholamines in stressHum Nutr Clin Nutr.(1983 Dec)
🧠🛡️ Захист нервової системи, захист нейронів, нейропротекція, нейромодуляція, неврологія, нейрогенез, нейротрофічний фактор росту - 29 досліджень [53-82]:
- Harrison FE1, May JMVitamin C function in the brain: vital role of the ascorbate transporter SVCT2Free Radic Biol Med.(2009 Mar 15)
- Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RLAscorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survivalNat Med.(2002 May)
- Lam DK, Daniel PMThe influx of ascorbic acid into the rat's brainQ J Exp Physiol.(1986 Jul)
- Agus DB, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DWVitamin C crosses the blood-brain barrier in the oxidized form through the glucose transportersJ Clin Invest.(1997 Dec 1)
- García Mde L, Salazar K, Millán C, Rodríguez F, Montecinos H, Caprile T, Silva C, Cortes C, Reinicke K, Vera JC, Aguayo LG, Olate J, Molina B, Nualart FSodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cellsGlia.(2005 Apr 1)
- Angelow S, Haselbach M, Galla HJFunctional characterisation of the active ascorbic acid transport into cerebrospinal fluid using primary cultured choroid plexus cellsBrain Res.(2003 Oct 24)
- Hakvoort A, Haselbach M, Galla HJActive transport properties of porcine choroid plexus cells in cultureBrain Res.(1998 Jun 8)
- Spector RVitamin homeostasis in the central nervous systemN Engl J Med.(1977 Jun 16)
- Spector R, Lorenzo AVAscorbic acid homeostasis in the central nervous systemAm J Physiol.(1973 Oct)
- Miele M, Fillenz MIn vivo determination of extracellular brain ascorbateJ Neurosci Methods.(1996 Dec)
- Schenk JO, Miller E, Gaddis R, Adams RNHomeostatic control of ascorbate concentration in CNS extracellular fluidBrain Res.(1982 Dec 16)
- Lönnrot K, Metsä-Ketelä T, Molnár G, Ahonen JP, Latvala M, Peltola J, Pietilä T, Alho HThe effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacityFree Radic Biol Med.(1996)
- Reiber H, Ruff M, Uhr MAscorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rateClin Chim Acta.(1993 Aug 31)
- Harrison FE, Green RJ, Dawes SM, May JMVitamin C distribution and retention in the mouse brainBrain Res.(2010 Aug 12)
- Milby K, Oke A, Adams RNDetailed mapping of ascorbate distribution in rat brainNeurosci Lett.(1982 Feb 12)
- Mefford IN, Oke AF, Adams RNRegional distribution of ascorbate in human brainBrain Res.(1981 May 11)
- Odumosu A, Wilson CWRegional brain ascorbic acid distribution: its functional relationship to appetite and leptazol-induced convulsions in guinea-pigsInt J Vitam Nutr Res.(1980)
- Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MAA family of mammalian Na+-dependent L-ascorbic acid transportersNature.(1999 May 6)
- Mun GH, Kim MJ, Lee JH, Kim HJ, Chung YH, Chung YB, Kang JS, Hwang YI, Oh SH, Kim JG, Hwang DH, Shin DH, Lee WJImmunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brainJ Neurosci Res.(2006 Apr)
- Diliberto EJ Jr, Allen PLSemidehydroascorbate as a product of the enzymic conversion of dopamine to norepinephrine. Coupling of semidehydroascorbate reductase to dopamine-beta-hydroxylaseMol Pharmacol.(1980 May)
- Diliberto EJ Jr, Allen PLMechanism of dopamine-beta-hydroxylation. Semidehydroascorbate as the enzyme oxidation product of ascorbateJ Biol Chem.(1981 Apr 10)
- Chatterjee IB, Majumder AK, Nandi BK, Subramanian NSynthesis and some major functions of vitamin C in animalsAnn N Y Acad Sci.(1975 Sep 30)
- Semenza GLHIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleusCell.(2001 Oct 5)
- Kuo CH, Hata F, Yoshida H, Yamatodani A, Wada HEffect of ascorbic acid on release of acetylcholine from synaptic vesicles prepared from different species of animals and release of noradrenaline from synaptic vesicles of rat brainLife Sci.(1979 Mar 5)
- Dhingra D, Parle M, Kulkarni SKComparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in miceJ Med Food.(2006 Summer)
- Ciani E, Grøneng L, Voltattorni M, Rolseth V, Contestabile A, Paulsen REInhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neuronsBrain Res.(1996 Jul 22)
- Atlante A, Gagliardi S, Minervini GM, Ciotti MT, Marra E, Calissano PGlutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formationJ Neurochem.(1997 May)
- Majewska MD, Bell JA, London EDRegulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbateBrain Res.(1990 Dec 24)
- Majewska MD, Bell JAAscorbic acid protects neurons from injury induced by glutamate and NMDANeuroreport.(1990 Nov-Dec)
🩸🍬 Розрідження крові, густа кров, недостатність кровопостачання, кровотік, інсульт, інфаркт, ішемія, анемія, гіпоксія, цукровий діабет, предіабет, інсулінорезистентність, профілактика діабету - 44 дослідження [82-126]:
- May JM, Harrison FERole of Vitamin C in the Function of the Vascular EndotheliumAntioxid Redox Signal.(2013 Apr 15)
- Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk BCOpposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolaeCirc Res.(1999 Jul 9)
- Kuzkaya N, Weissmann N, Harrison DG, Dikalov SInteractions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthaseJ Biol Chem.(2003 Jun 20)
- Heller R, Münscher-Paulig F, Gräbner R, Till UL-Ascorbic acid potentiates nitric oxide synthesis in endothelial cellsJ Biol Chem.(1999 Mar 19)
- Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner ERL-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterinJ Biol Chem.(2001 Jan 5)
- Huang A, Vita JA, Venema RC, Keaney JF JrAscorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterinJ Biol Chem.(2000 Jun 9)
- Sönmez MF, Narin F, Akkuş D, Türkmen ABMelatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidneyRen Fail.(2012)
- Sönmez MF, Narin F, Akkuş D, Ozdamar SEffect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic ratsToxicol Ind Health.(2009 Jul)
- Bendich A, Machlin LJ, Scandurra OThe antioxidant role of vitamin CAdv Free Radical Biol Med.(1986)
- Ischiropoulos HBiological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen speciesArch Biochem Biophys.(1998 Aug 1)
- Millar JThe nitric oxide/ascorbate cycle: how neurones may control their own oxygen supplyMed Hypotheses.(1995 Jul)
- Scorza G, Pietraforte D, Minetti MRole of ascorbate and protein thiols in the release of nitric oxide from S-nitroso-albumin and S-nitroso-glutathione in human plasmaFree Radic Biol Med.(1997)
- Ginter EVitamin-C deficiency and gallstone formationLancet.(1971 Nov 27)
- [No authors listedAscorbic acid and the catabolism of cholesterolNutr Rev.(1973 May)
- Turley SD, West CE, Horton BJThe role of ascorbic acid in the regulation of cholesterol metabolism and in the pathogenesis of atherosclerosisAtherosclerosis.(1976 Jul-Aug)
- Ginter EMarginal vitamin C deficiency, lipid metabolism, and atherogenesisAdv Lipid Res.(1978)
- Steffner RJ, Wu L, Powers AC, May JMAscorbic acid recycling by cultured beta cells: effects of increased glucose metabolismFree Radic Biol Med.(2004 Nov 15)
- Lenzen S, Drinkgern J, Tiedge MLow antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissuesFree Radic Biol Med.(1996)
- Malaisse WJ, Malaisse-Lagae F, Sener A, Pipeleers DGDeterminants of the selective toxicity of alloxan to the pancreatic B cellProc Natl Acad Sci U S A.(1982 Feb)
- Wells WW, Dou CZ, Dybas LN, Jung CH, Kalbach HL, Xu DPAscorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic isletsProc Natl Acad Sci U S A.(1995 Dec 5)
- Zhou A, Thorn NAHigh ascorbic acid content in the rat endocrine pancreasDiabetologia.(1991 Nov)
- Mooradian ADEffect of ascorbate and dehydroascorbate on tissue uptake of glucoseDiabetes.(1987 Sep)
- Johnston CS, Yen MFMegadose of vitamin C delays insulin response to a glucose challenge in normoglycemic adultsAm J Clin Nutr.(1994 Nov)
- Dakhale GN, Chaudhari HV, Shrivastava MSupplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind studyAdv Pharmacol Sci.(2011)
- Ellulu MS, Rahmat A, Patimah I, Khaza'ai H, Abed YEffect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trialDrug Des Devel Ther.(2015 Jul 1)
- Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GDAscorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trialDiabetes Obes Metab.(2019 Mar)
- Bishop N, Schorah CJ, Wales JKThe effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover studyDiabet Med.(1985 Mar)
- Rafighi Z, Shiva A, Arab S, Mohd Yousof RAssociation of dietary vitamin C and e intake and antioxidant enzymes in type 2 diabetes mellitus patientsGlob J Health Sci.(2013 Mar 20)
- Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JDInfluence of vitamin C supplementation on oxidative and immune changes after an ultramarathonJ Appl Physiol (1985).(2002 May)
- Ghaffari P, Nadiri M, Gharib A, Rahimi FThe effects of vitamin C on diabetic patientsPharm Lett.(2015)
- Bhatt JK, Thomas S, Nanjan MJEFFECT OF ORAL SUPPLEMENTATION OF VITAMIN C ON GLYCEMIC CONTROL AND LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES MELLITUSInt J Pharm Pharm Sci.(2012 Feb 21)
- Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GDAscorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled studyFree Radic Biol Med.(2016 Apr)
- Siavash M, Amini MVitamin C may have similar beneficial effects to Gemfibrozil on serum high-density lipoprotein-cholesterol in type 2 diabetic patientsJ Res Pharm Pract.(2014 Jul)
- Davison GW, Ashton T, George L, Young IS, McEneny J, Davies B, Jackson SK, Peters JR, Bailey DMMolecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trialDiabetologia.(2008 Nov)
- Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou K, Charakida M, Ntarladimas I, Siasos G, Stefanadis CEffects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitusHeart.(2007 Feb)
- Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO 3rd, Wang Y, Katz A, Levine M, Quon MJHigh-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistanceAm J Physiol Heart Circ Physiol.(2006 Jan)
- Klein F, Juhl B, Christiansen JSUnchanged renal haemodynamics following high dose ascorbic acid administration in normoalbuminuric IDDM patientsScand J Clin Lab Invest.(1995 Feb)
- Gokce N, Keaney JF Jr, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JALong-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery diseaseCirculation.(1999 Jun 29)
- Pirbudak L, Balat O, Cekmen M, Ugur MG, Aygün S, Oner UEffect of ascorbic acid on surgical stress response in gynecologic surgeryInt J Clin Pract.(2004 Oct)
- Johnston CS, Yen MFMegadose of vitamin C delays insulin response to a glucose challenge in normoglycemic adultsAm J Clin Nutr.(1994 Nov)
- Pleiner J, Schaller G, Mittermayer F, Bayerle-Eder M, Roden M, Wolzt MFFA-induced endothelial dysfunction can be corrected by vitamin CJ Clin Endocrinol Metab.(2002 Jun)
- Bo S, Ciccone G, Durazzo M, Gambino R, Massarenti P, Baldi I, Lezo A, Tiozzo E, Pauletto D, Cassader M, Pagano GEfficacy of antioxidant treatment in reducing resistin serum levels: a randomized studyPLoS Clin Trials.(2007 May 4)
- Mahmoudabadi MM, Djalali M, Djazayery SA, Keshavarz SA, Eshraghian MR, Yaraghi AA, Askari G, Ghiasvand R, Zarei MEffects of eicosapentaenoic acid and vitamin C on glycemic indices, blood pressure, and serum lipids in type 2 diabetic Iranian malesJ Res Med Sci.(2011 Mar)
- Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo MEffects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trialsEur J Clin Nutr.(2017 Dec)
🍌 Тестостерон, ерекція, потенція, лібідо, сексуальна (інтимна) сила, спортивні показники, сила - 6 досліджень [126-132]:
- Ayinde OC, Ogunnowo S, Ogedegbe RA, Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead-exposed albino rats, BMC Pharmacol Toxicol.(2012 Dec 14)
- Harikrishnan R, Abhilash PA, Das SS, Prathibha P, Rejitha S, John F, Kavitha S, Indira M, Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs, Br J Nutr.(2013 Jan 21:1-10)
- Jewo PI, Duru FI, Fadeyibi IO, Saalu LC, Noronha CC, The protective role of ascorbic acid in burn-induced testicular damage in rats, Burns.(2012 Feb)
- Saki G, Jasemi M, Sarkaki AR, Fathollahi A, Effect of administration of vitamins C and E on fertilization capacity of rats exposed to noise stress, Noise Health.(2013 May-Jun)
- Takhshid MA, Tavasuli AR, Heidary Y, Keshavarz M, Kargar H, Protective effect of vitamins e and C on endosulfan-induced reproductive toxicity in male rats, Iran J Med Sci.(2012 Sep)
- Vani K, Kurakula M, Syed R, Alharbi K, Clinical relevance of vitamin C among lead-exposed infertile men, Genet Test Mol Biomarkers.(2012 Sep)
💥🏋️♂️ Наднирники, енергія, мотивація, впевненість, рішучість, гормони, нейромедіатори - 12 досліджень [132-144]:
- Flatmark T, Terland O, Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b-type cytochrome, Biochim Biophys Acta.(1971 Dec 7)
- Njus D, Knoth J, Cook C, Kelly PM, Electron transfer across the chromaffin granule membrane, J Biol Chem.(1983 Jan 10)
- Levine M, Asher A, Pollard H, Zinder O, Ascorbic acid and catecholamine secretion from cultured chromaffin cells, J Biol Chem.(1983 Nov 10)
- Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M, Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone, Am J Clin Nutr.(2007 Jul)
- Stone KJ, Townsley BH, The effect of L-ascorbate on catecholamine biosynthesis, Biochem J.(1973 Mar)
- Kurtzman D, Dupont J, Lian F, Curiel-Lewandrowski C, Fatigue and lower-extremity ecchymosis in a 36-year-old woman. Scurvy, Arch Dermatol.(2012 Sep 1)
- Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK, Scurvy: a disease almost forgotten, Int J Dermatol.(2006 Aug)
- Hirschmann JV, Raugi GJ, Adult scurvy, J Am Acad Dermatol.(1999 Dec)
- Amano A, Tsunoda M, Aigaki T, Maruyama N, Ishigami A, Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice, Eur J Nutr.(2013 Mar 19)
- Menniti FS, Knoth J, Diliberto EJ Jr, Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration, J Biol Chem.(1986 Dec 25)
- Richards ML, Sadee W, Human neuroblastoma cell lines as models of catechol uptake, Brain Res.(1986 Oct 1)
- May JM, Qu ZC, Nazarewicz R, Dikalov S, Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine, Brain Res Bull.(2013 Jan)
🦠🔴 Імунітет, рак, пухлини, онкозахворювання, Т-клітини, профілактика онкозахворювань - 7 досліджень [144-151]:
- Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J, Frytak SFailure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial N Engl J Med.(1979 Sep 27)
- Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LCVitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDHScience.(2015 Dec 11)
- Cameron E, Pauling LSupplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancerProc Natl Acad Sci U S A.(1976 Oct)
- Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MMHigh-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparisonN Engl J Med.(1985 Jan 17)
- Watson JOxidants, antioxidants and the current incurability of metastatic cancersOpen Biol.(2013 Jan 8)
- Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine MPharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in miceProc Natl Acad Sci U S A.(2008 Aug 12)
- Cairns RADrivers of the Warburg phenotypeCancer J.(2015 Mar-Apr)
🛡️🦠🌡️ Імунітет, імуномодулятор, запалення, інфекції, віруси, Т-клітини, простуда, грип - 4 дослідження [151-155]:
- Hemilä H, Chalker E, Vitamin C for preventing and treating the common cold, Cochrane Database Syst Rev.(2013 Jan 31)
- Bailey DM, Williams C, Betts JA, Thompson D, Hurst TL, Oxidative stress, inflammation and recovery of muscle function after damaging exercise: effect of 6-week mixed antioxidant supplementation, Eur J Appl Physiol.(2011 Jun)
- Ekkekakis P, Lind E, Exercise does not feel the same when you are overweight: the impact of self-selected and imposed intensity on affect and exertion, Int J Obes (Lond).(2006 Apr)
- Huck CJ, Johnston CS, Beezhold BL, Swan PD, Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet, Nutrition.(2012 Jun 5)
🌿🧹 Детокс, очищення організму, антиоксидант, закислення організму, окислення ліпідів, пошкодження ДНК, очищення від важких металів - 31 дослідження [155-186]:
- Schulze HR, Gallenkamp H, Staudinger H, Microsomal NADH-dependent electron transport, Hoppe Seylers Z Physiol Chem.(1970 Jul)
- Lumper L, Schneider W, Staudinger H, Studies on the kinetics of microsomal NADH:semidehydroascorbate oxidoreductase, Hoppe Seylers Z Physiol Chem.(1967 Mar)
- Wakefield LM, Cass AE, Radda GK, Electron transfer across the chromaffin granule membrane. Use of EPR to demonstrate reduction of intravesicular ascorbate radical by the extravesicular mitochondrial NADH:ascorbate radical oxidoreductase, J Biol Chem.(1986 Jul 25)
- Bielski BHJ, Allen AO, Schwarz HA, Mechanism of the disproportionation of ascorbate radicals, J Am Chem Soc.(1981 Jun)
- Wells WW, Xu DP, Dehydroascorbate reduction, J Bioenerg Biomembr.(1994 Aug)
- Jackson TS, Xu A, Vita JA, Keaney JF Jr, Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations, Circ Res.(1998 Nov 2)
- Landino LM, Koumas MT, Mason CE, Alston JA, Ascorbic acid reduction of microtubule protein disulfides and its relevance to protein S-nitrosylation assays, Biochem Biophys Res Commun.(2006 Feb 10)
- Buettner GR, The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate, Arch Biochem Biophys.(1993 Feb 1)
- Buettner GR, Jurkiewicz BA, Catalytic metals, ascorbate and free radicals: combinations to avoid, Radiat Res.(1996 May)
- Buettner GR, Ascorbate oxidation: UV absorbance of ascorbate and ESR spectroscopy of the ascorbyl radical as assays for iron, Free Radic Res Commun.(1990)
- Buettner GR, Ascorbate autoxidation in the presence of iron and copper chelates, Free Radic Res Commun.(1986)
- Buettner GR, In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals, J Biochem Biophys Methods.(1988 May)
- Alessio HM, Goldfarb AH, Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training, J Appl Physiol.(1988 Apr)
- Heitkamp HC, Wegler S, Brehme U, Heinle H, Effect of an 8-week endurance training program on markers of antioxidant capacity in women, J Sports Med Phys Fitness.(2008 Mar)
- Higuchi M, Cartier LJ, Chen M, Holloszy JO, Superoxide Dismutase and Catalase in Skeletal Muscle: Adaptive Response to Exercise, J Gerontol.(1985)
- Oh-ishi S, Kizaki T, Nagasawa J, Izawa T, Komabayashi T, Nagata N, Suzuki K, Taniguchi N, Ohno H, Effects of endurance training on superoxide dismutase activity, content and mRNA expression in rat muscle, Clin Exp Pharmacol Physiol.(1997 May)
- Yfanti C, Fischer CP, Nielsen S, Akerström T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BK, Role of vitamin C and E supplementation on IL-6 in response to training, J Appl Physiol.(2012 Mar)
- Richardson ME, Fox MR, Fry BE Jr, Pathological changes produced in Japanese quail by ingestion of cadmium, J Nutr.(1974 Mar)
- Fox MR, Protective effects of ascorbic acid against toxicity of heavy metals, Ann N Y Acad Sci.(1975 Sep 30)
- Fox MRS, Jacobs RM, Jones AOL, Fry Jr BE, Stone CL, EFFECTS OF VITAMIN C AND IRON ON CADMIUM METABOLISM, Ann NY Acad Sci.(1980 Dec)
- Fox MR, Fry BE Jr, Harland BF, Schertel ME, Weeks CE, Effect of ascorbic acid on cadmium toxicity in the young coturnix, J Nutr.(1971 Oct)
- Suzuki T, Yoshida A, Long-term effectiveness of dietary iron and ascorbic acid in the prevention and cure of cadmium toxicity in rats, Am J Clin Nutr.(1978 Sep)
- Hill CH, Interactions of vitamin C with lead and mercury, Ann N Y Acad Sci.(1980)
- Blackstone S, Hurley RJ, Hughes RE, Some inter-relationships between vitamin C (L-ascorbic acid) and mercury in the guinea-pig, Food Cosmet Toxicol.(1974 Aug)
- Murray DR, Hughes RE, The influence of dietary ascorbic acid on the concentration of mercury in guinea-pig tissues {proceedings}, Proc Nutr Soc.(1976 Dec)
- Chatterjee GC, Pal DR, Metabolism of L-ascorbic acid in rats under in vivo administration of mercury: effect of L-ascorbic acid supplementation, Int J Vitam Nutr Res.(1975)
- Goyer RA, Cherian MG, Ascorbic acid and EDTA treatment of lead toxicity in rats, Life Sci.(1979 Jan 29)
- Calabrese EJ, Stoddard A, Leonard DA, Dinardi SR, The effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury, Ann N Y Acad Sci.(1987)
- Sohler A, Kruesi M, Pfeiffer CC, Blood Lead Levels in Psychiatric Outpatients Reduced by Zinc and Vitamin C, J Orthomol Psychiatry.(1977)
- Naha N, Manna B, Mechanism of lead induced effects on human spermatozoa after occupational exposure, Kathmandu Univ Med J (KUMJ).(2007 Jan-Mar)
- Naha N, Chowdhury AR, Inorganic lead exposure in battery and paint factory: effect on human sperm structure and functional activity, J UOEH.(2006 Jun 1)
🤰👶 Вагітність і розвиток дітей - 8 досліджень [186-194]:
- Kratzing CC, Kelly JD, Kratzing JE, Ascorbic acid in fetal rat brain, J Neurochem.(1985 May)
- Kratzing CC, Kelly JD, Tissue levels of ascorbic acid during rat gestation, Int J Vitam Nutr Res.(1982)
- Zalani S, Rajalakshmi R, Parekh LJ, Ascorbic acid concentration of human fetal tissues in relation to fetal size and gestational age, Br J Nutr.(1989 May)
- Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S, Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain, Br J Nutr.(2007 Dec)
- Harrison FE, Meredith ME, Dawes SM, Saskowski JL, May JM, Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development, Brain Res.(2010 Aug 19)
- Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, May JM, Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2, Free Radic Biol Med.(2010 Sep 1)
- Tveden-Nyborg P, Johansen LK, Raida Z, Villumsen CK, Larsen JO, Lykkesfeldt J, Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs, Am J Clin Nutr.(2009 Sep)
- Tveden-Nyborg P, Vogt L, Schjoldager JG, Jeannet N, Hasselholt S, Paidi MD, Christen S, Lykkesfeldt J, Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs, PLoS One.(2012)
👇 Компонент №2 - Eсhinacea (ехінацея) 🌿:
😊🩺 Загальний вплив на здоров'я, самопочуття та захворюваність організму - 57 досліджень [194-251]:
-Hermann R, von Richter OClinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactionsPlanta Med.(2012 Sep)
-Wu L, Rowe EW, Jeftinija K, Jeftinija S, Rizshsky L, Nikolau BJ, McKay J, Kohut M, Wurtele ESEchinacea-induced cytosolic Ca2+ elevation in HEK293BMC Complement Altern Med.(2010 Nov 23)
-Dalby-Brown L, Barsett H, Landbo AK, Meyer AS, Mølgaard PSynergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteinsJ Agric Food Chem.(2005 Nov 30)
-Najm W, Lie DDietary supplements commonly used for preventionPrim Care.(2008 Dec)
-Ma H, Carpenter CL, Sullivan-Halley J, Bernstein LThe roles of herbal remedies in survival and quality of life among long-term breast cancer survivors--results of a prospective studyBMC Cancer.(2011 Jun 6)
-Bright-Gbebry M, Makambi KH, Rohan JP, Llanos AA, Rosenberg L, Palmer JR, Adams-Campbell LLUse of multivitamins, folic acid and herbal supplements among breast cancer survivors: the black women's health studyBMC Complement Altern Med.(2011 Apr 15)
-Engdal S, Klepp O, Nilsen OGIdentification and exploration of herb-drug combinations used by cancer patientsIntegr Cancer Ther.(2009 Mar)
-Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, Oliver SJ, Bermon S, Kajeniene APosition statement. Part two: Maintaining immune healthExerc Immunol Rev.(2011)
-Senchina DS, Shah NB, Doty DM, Sanderson CR, Hallam JEHerbal supplements and athlete immune function--what's proven, disproven, and unprovenExerc Immunol Rev.(2009)
-Ritchie MR, Gertsch J, Klein P, Schoop REffects of Echinaforce® treatment on ex vivo-stimulated blood cellsPhytomedicine.(2011 Jul 15)
-Thomsen MO, Fretté XC, Christensen KB, Christensen LP, Grevsen KSeasonal variations in the concentrations of lipophilic compounds and phenolic acids in the roots of Echinacea purpurea and Echinacea pallidaJ Agric Food Chem.(2012 Dec 12)
-Hohmann J, Rédei D, Forgo P, Szabó P, Freund TF, Haller J, Bojnik E, Benyhe SAlkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptorsPhytochemistry.(2011 Oct)
-The constituents of Echinacea atrorubens roots and aerial parts.()
-Spelman K, Wetschler MH, Cech NBComparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MSJ Pharm Biomed Anal.(2009 Jul 12)
-Bauer R, Remiger PTLC and HPLC Analysis of Alkamides in Echinacea Drugs1,2Planta Med.(1989 Aug)
-Alkamides from the roots of Echinacea angustifolia.()
-Chen Y, Fu T, Tao T, Yang J, Chang Y, Wang M, Kim L, Qu L, Cassady J, Scalzo R, Wang XMacrophage activating effects of new alkamides from the roots of Echinacea speciesJ Nat Prod.(2005 May)
-Lu Y, Li J, Li M, Hu X, Tan J, Liu ZHEfficient counter-current chromatographic isolation and structural identification of two new cinnamic acids from Echinacea purpureaNat Prod Commun.(2012 Oct)
-Benson JM, Pokorny AJ, Rhule A, Wenner CA, Kandhi V, Cech NB, Shepherd DMEchinacea purpurea extracts modulate murine dendritic cell fate and functionFood Chem Toxicol.(2010 May)
-Liu Y, Zhang S, Zhang F, Hu RAdjuvant activity of Chinese herbal polysaccharides in inactivated veterinary rabies vaccinesInt J Biol Macromol.(2012 Apr 1)
-Di Pierro F, Rapacioli G, Ferrara T, Togni SUse of a standardized extract from Echinacea angustifolia (Polinacea) for the prevention of respiratory tract infectionsAltern Med Rev.(2012 Mar)
-Ragupathi G, Yeung KS, Leung PC, Lee M, Lau CB, Vickers A, Hood C, Deng G, Cheung NK, Cassileth B, Livingston PEvaluation of widely consumed botanicals as immunological adjuvantsVaccine.(2008 Sep 2)
-TLC and HPLC Analysis of Alkamides in Echinacea Drugs.()
-Chicca A, Pellati F, Adinolfi B, Matthias A, Massarelli I, Benvenuti S, Martinotti E, Bianucci AM, Bone K, Lehmann R, Nieri PCytotoxic activity of polyacetylenes and polyenes isolated from roots of Echinacea pallidaBr J Pharmacol.(2008 Mar)
-Binns SE, Livesey JF, Arnason JT, Baum BRPhytochemical variation in echinacea from roots and flowerheads of wild and cultivated populationsJ Agric Food Chem.(2002 Jun 19)
-Rininger JA, Kickner S, Chigurupati P, McLean A, Franck ZImmunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cellsJ Leukoc Biol.(2000 Oct)
-Pugh ND, Tamta H, Balachandran P, Wu X, Howell J, Dayan FE, Pasco DSThe majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharidesInt Immunopharmacol.(2008 Jul)
-Pugh ND, Jackson CR, Pasco DSTotal bacterial load within Echinacea purpurea, determined using a new PCR-based quantification method, is correlated with LPS levels and in vitro macrophage activityPlanta Med.(2013 Jan)
-Brinkeborn RM, Shah DV, Degenring FHEchinaforce and other Echinacea fresh plant preparations in the treatment of the common cold. A randomized, placebo controlled, double-blind clinical trialPhytomedicine.(1999 Mar)
-Kim HO, Durance TD, Scaman CH, Kitts DDRetention of alkamides in dried Echinacea purpureaJ Agric Food Chem.(2000 Sep)
-Kim HO, Durance TD, Scaman CH, Kitts DDRetention of caffeic acid derivatives in dried Echinacea purpureaJ Agric Food Chem.(2000 Sep)
-Stuart DL, Wills RBEffect of drying temperature on alkylamide and cichoric acid concentrations of Echinacea purpureaJ Agric Food Chem.(2003 Mar 12)
-Livesey J, Awang DV, Arnason JT, Letchamo W, Barrett M, Pennyroyal GEffect of temperature on stability of marker constituents in Echinacea purpurea root formulationsPhytomedicine.(1999 Nov)
-Effect of handling and storage on alkylamides and cichoric acid in Echinacea purpurea.()
-Patterson MFMicrobiology of pressure-treated foodsJ Appl Microbiol.(2005)
-Chen XM, Hu C, Raghubeer E, Kitts DDEffect of high pressure pasteurization on bacterial load and bioactivity of Echinacea purpureaJ Food Sci.(2010 Sep)
-Advantages of high pressure sterilisation on quality of food products.()
-Schapowal AEfficacy and safety of Echinaforce® in respiratory tract infectionsWien Med Wochenschr.(2013 Feb)
-Woelkart K, Marth E, Suter A, Schoop R, Raggam RB, Koidl C, Kleinhappl B, Bauer RBioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune systemInt J Clin Pharmacol Ther.(2006 Sep)
-Gertsch J, Schoop R, Kuenzle U, Suter AEchinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathwaysFEBS Lett.(2004 Nov 19)
-Shah SA, Sander S, White CM, Rinaldi M, Coleman CIEvaluation of echinacea for the prevention and treatment of the common cold: a meta-analysisLancet Infect Dis.(2007 Jul)
-Matthias A, Blanchfield JT, Penman KG, Toth I, Lang CS, De Voss JJ, Lehmann RPPermeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer modelJ Clin Pharm Ther.(2004 Feb)
-Jager H, Meinel L, Dietz B, Lapke C, Bauer R, Merkle HP, Heilmann JTransport of alkamides from Echinacea species through Caco-2 monolayersPlanta Med.(2002 May)
-Matthias A, Penman KG, Matovic NJ, Bone KM, De Voss JJ, Lehmann RPBioavailability of Echinacea constituents: Caco-2 monolayers and pharmacokinetics of the alkylamides and caffeic acid conjugatesMolecules.(2005 Oct 30)
-Matthias A, Gillam EM, Penman KG, Matovic NJ, Bone KM, De Voss JJ, Lehmann RPCytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomesChem Biol Interact.(2005 Jun 30)
-Woelkart K, Koidl C, Grisold A, Gangemi JD, Turner RB, Marth E, Bauer RBioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humansJ Clin Pharmacol.(2005 Jun)
-Matthias A, Addison RS, Penman KG, Dickinson RG, Bone KM, Lehmann RPEchinacea alkamide disposition and pharmacokinetics in humans after tablet ingestionLife Sci.(2005 Sep 2)
-Goey AK, Rosing H, Meijerman I, Sparidans RW, Schellens JH, Beijnen JHThe bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MSJ Chromatogr B Analyt Technol Biomed Life Sci.(2012 Aug 1)
-Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SDThe effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivoClin Pharmacol Ther.(2004 Jan)
-Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, Khan IA, Edwards DJ, Shah AIn vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmettoClin Pharmacol Ther.(2004 Nov)
-Gurley BJ, Swain A, Hubbard MA, Williams DK, Barone G, Hartsfield F, Tong Y, Carrier DJ, Cheboyina S, Battu SKClinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and EchinaceaMol Nutr Food Res.(2008 Jul)
-Moltó J, Valle M, Miranda C, Cedeño S, Negredo E, Barbanoj MJ, Clotet BHerb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patientsAntimicrob Agents Chemother.(2011 Jan)
-Penzak SR, Robertson SM, Hunt JD, Chairez C, Malati CY, Alfaro RM, Stevenson JM, Kovacs JAEchinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjectsPharmacotherapy.(2010 Aug)
-Abdul MI, Jiang X, Williams KM, Day RO, Roufogalis BD, Liauw WS, Xu H, Matthias A, Lehmann RP, McLachlan AJPharmac
-Wittkowsky AKWarfarin and other coumarin derivatives: pharmacokinetics, pharmacodynamics, and drug interactionsSemin Vasc Med.(2003 Aug)
-Mahringer A, Ardjomand-Woelkart K, Bauer R, Fricker G, Efferth TAlkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood VesselsPlanta Med.(2013 Mar)
-Qiang Z, Hauck C, McCoy JA, Widrlechner MP, Reddy MB, Murphy PA, Hendrich SEchinacea sanguinea and Echinacea pallida Extracts Stimulate Glucuronidation and Basolateral Transfer of Bauer Alkamides 8 and 10 and Ketone 24 and Inhibit P-glycoprotein Transporter in Caco-2 CellsPlanta Med.(2013 Mar)
🧬 Неврологія, нейрони, нейротрансмітери, нейромедіатори, нервові сигнали - 3 дослідження [251-254]:
-Woelkart K, Xu W, Pei Y, Makriyannis A, Picone RP, Bauer RThe endocannabinoid system as a target for alkamides from Echinacea angustifolia rootsPlanta Med.(2005 Aug)
-Chicca A, Raduner S, Pellati F, Strompen T, Altmann KH, Schoop R, Gertsch JSynergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extractsInt Immunopharmacol.(2009 Jul)
-Raduner S, Majewska A, Chen JZ, Xie XQ, Hamon J, Faller B, Altmann KH, Gertsch JAlkylamides from Echinacea are a new class of cannabin
😥 Стрес, напруга, невроз, тривога - 3 дослідження [254-257]:
-Haller J, Bakos N, Szirmay M, Ledent C, Freund TFThe effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxietyEur J Neurosci.(2002 Oct)
-Gertsch JImmunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid systemPlanta Med.(2008 May)
-Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman DPharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)CNS Drug Rev.(2006 Spring)
-Haller J, Freund TF, Pelczer KG, Füredi J, Krecsak L, Zámbori JThe anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteersPhytother Res.(2013 Jan)
🦠🌡️ Імунітет, імуномодулятор, запалення, інфекції, віруси, Т-клітини, застуда - 35 досліджень [257-292]:
-Shah SA, Schlesselman L, Cios D, Lipeika J, Patel AA, Kluger J, White CMEffects of echinacea on electrocardiographic and blood pressure measurementsAm J Health Syst Pharm.(2007 Aug 1)
-Pertwee RGThe pharmacology of cannabinoid receptors and their ligands: an overviewInt J Obes (Lond).(2006 Apr)
-Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R, Basu TKAlkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal ratsInt Immunopharmacol.(2002 Feb)
-Sullivan AM, Laba JG, Moore JA, Lee TDEchinacea-induced macrophage activationImmunopharmacol Immunotoxicol.(2008)
-Stevenson LM, Matthias A, Banbury L, Penman KG, Bone KM, Leach DL, Lehmann RPModulation of macrophage immune responses by EchinaceaMolecules.(2005 Oct 31)
-Tamta H, Pugh ND, Balachandran P, Moraes R, Sumiyanto J, Pasco DSVariability in in vitro macrophage activation by commercially diverse bulk echinacea plant material is predominantly due to bacterial lipoproteins and lipopolysaccharidesJ Agric Food Chem.(2008 Nov 26)
-Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ, Hauschildt SLPS-induced cytokine production in human monocytes and macrophagesCrit Rev Immunol.(2011)
-Senchina DS, Strauch JH, Hoffmann GB, Shah NB, Laflen BK, Dumke BL, Dao CT, Dias AS, Perera MAPhytochemical and immunomodulatory properties of an Echinacea laevigata (Asteraceae) tinctureJ Altern Complement Med.(2011 Apr)
-Kapai NA, Anisimova NY, Kiselevskii MV, Sitdikova SM, Slavetskaya MBSelective cytokine-inducing effects of low dose EchinaceaBull Exp Biol Med.(2011 Apr)
-Skopińska-Rózewska E, Sokolnicka I, Siwicki AK, Stankiewicz W, Dabrowski MP, Buchwald W, Krajewska-Patan A, Mielcarek S, Mścisz A, Furmanowa MDose-dependent in vivo effect of Rhodiola and Echinacea on the mitogen-induced lymphocyte proliferation in micePol J Vet Sci.(2011)
-Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, Kohut ML, Cunnick JEEnhancement of innate and adaptive immune functions by multiple Echinacea speciesJ Med Food.(2007 Sep)
-Sasagawa M, Cech NB, Gray DE, Elmer GW, Wenner CAEchinacea alkylamides inhibit interleukin-2 production by Jurkat T cellsInt Immunopharmacol.(2006 Jul)
-Mishima S, Saito K, Maruyama H, Inoue M, Yamashita T, Ishida T, Gu YAntioxidant and immuno-enhancing effects of Echinacea purpureaBiol Pharm Bull.(2004 Jul)
-Morazzoni P, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso TIn vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea)Fitoterapia.(2005 Jul)
-Schwarz E, Parlesak A, Henneicke-von Zepelin HH, Bode JC, Bode CEffect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B- and T-lymphocytes in healthy volunteers: results of a double-blind, placebo-controlled cross-over studyPhytomedicine.(2005 Sep)
-Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka KImmunobiology of dendritic cellsAnnu Rev Immunol.(2000)
-Wang CY, Chiao MT, Yen PJ, Huang WC, Hou CC, Chien SC, Yeh KC, Yang WC, Shyur LF, Yang NSModulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based studyGenomics.(2006 Dec)
-Wang CY, Staniforth V, Chiao MT, Hou CC, Wu HM, Yeh KC, Chen CH, Hwang PI, Wen TN, Shyur LF, Yang NSGenomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cellsBMC Genomics.(2008 Oct 13)
-Dong GC, Chuang PH, Chang KC, Jan PS, Hwang PI, Wu HB, Yi M, Zhou HX, Chen HMBlocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptorPharm Res.(2009 Feb)
-Yin SY, Wang WH, Wang BX, Aravindaram K, Hwang PI, Wu HM, Yang NSStimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analysesBMC Genomics.(2010 Nov 1)
-Yu D, Yuan Y, Jiang L, Tai Y, Yang X, Hu F, Xie ZAnti-inflammatory effects of essential oil in Echinacea purpurea LPak J Pharm Sci.(2013 Mar)
-Rehman J, Dillow JM, Carter SM, Chou J, Le B, Maisel ASIncreased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensisImmunol Lett.(1999 Jun 1)
-Woelkart K, Linde K, Bauer REchinacea for preventing and treating the common coldPlanta Med.(2008 May)
-Schoop R, Klein P, Suter A, Johnston SLEchinacea in the prevention of induced rhinovirus colds: a meta-analysisClin Ther.(2006 Feb)
-Linde K, Barrett B, Wölkart K, Bauer R, Melchart DEchinacea for preventing and treating the common coldCochrane Database Syst Rev.(2006 Jan 25)
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-Taylor JA, Weber W, Standish L, Quinn H, Goesling J, McGann M, Calabrese CEfficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trialJAMA.(2003 Dec 3)
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